Claustrum sparing sign in seronegative limbic encephalitis DOI Creative Commons
Abeer Sabry Safan,

Mohammad Altermanini,

Mohamed Abdelhady

et al.

eNeurologicalSci, Journal Year: 2023, Volume and Issue: 31, P. 100465 - 100465

Published: May 17, 2023

Limbic encephalitis (LE) is a rare variant of autoimmune encephalitis. It often manifests with subacute neuropsychiatric symptoms agitation, delusions, variable seizure semiology, and short-term memory loss. Seronegative limbic can pose diagnostic conundrum owing to its inadequately understood pathophysiology. We report case young male manifestations agitations seizures. He was diagnosed seronegative (SNLE). Brain MRI demonstrated bilateral Claustrum sparing sign. An EEG showed continuous left-sided epileptiform discharges in periodic predominantly left middle temporal. Patient condition gradually improved pulsed methylprednisolone, intravenous immunoglobulins anti-seizure medications. remains one the least neuroanatomical structures. sign has been reported febrile infection-related epilepsy syndrome (FIRES), LE, refractory epilepsy. To best our knowledge, we first literature Encephalitis. Further experimental models researches are warranted better understand unique function claustrum unravel possible other attributable auto-antibodies, which could alter treatment prognosis.

Language: Английский

The cognitive dysfunction of claustrum on Alzheimer’s disease: A mini-review DOI Creative Commons
Chunyan Chen,

Guang-Yi Yang,

Hai-Xia Tu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: April 14, 2023

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases characterized by cognitive deficits and dementia. AD entails predominant pathological characteristics including amyloid beta (Aβ) plaque formation, neurofibrillary entanglements, brain atrophy, which gradually result in dysfunctions. Studies showed that these changes are found a myriad structures, claustrum (CLA), nucleus penetrates deeply into extensively interconnected to various structures. The CLA modulates many aspects functions, with attention, executive function, visuospatial ability, language, memory particular. It also implicated multiple neuropsychiatric disorders, worthy particular attention AD-related impairments. To inspire novel treatment strategies, this review has summarized functionality discriminative dysfunctions AD. And then propose an array potential mechanisms might contribute impairments caused abnormal physiology. We advocate be new promising therapeutic target combination existing anti-AD drugs stimulation approaches for future treatment.

Language: Английский

Citations

7
Involvement of the claustrum in the cortico-basal ganglia circuitry: connectional study in the non-human primate DOI Creative Commons
Elena Borra,

Gemma Ballestrazzi,

Dalila Biancheri

et al.

Brain Structure and Function, Journal Year: 2024, Volume and Issue: 229(5), P. 1143 - 1164

Published: April 14, 2024

Abstract The claustrum is an ancient telencephalic subcortical structure displaying extensive, reciprocal connections with much of the cortex and receiving projections from thalamus, amygdala, hippocampus. This has a general role in modulating cortical excitability considered to be engaged different cognitive motor functions, such as sensory integration perceptual binding, salience-guided attention, top-down executive well control brain states, sleep its interhemispheric integration. present study first describe detail projection striatum macaque brain. Based on tracer injections striatal regions areas, we observed rough topography claustral connectivity, thanks which zone projects both specific territory areas involved network projecting same territory. data add new elements complexity basal ganglia information processing mode non-motor functions provide evidence for influence functional domains cortico-basal circuits.

Language: Английский

Citations

2
The Telencephalon DOI
Barbara Buccilli, Sajad Sahab Negah,

Sadegh Shirian

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 429 - 451

Published: Aug. 30, 2024

Language: Английский

Citations

2
Recent Reports on Redox Stress-Induced Mitochondrial DNA Variations, Neuroglial Interactions, and NMDA Receptor System in Pathophysiology of Schizophrenia DOI
Narasimha M. Beeraka, Marco Ávila-Rodriguez, Gjumrakch Aliev

et al.

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(4), P. 2472 - 2496

Published: Jan. 26, 2022

Language: Английский

Citations

10
Influence of the anatomical features of different brain regions on the spatial localization of fiber photometry signals DOI Creative Commons
Cinzia Montinaro, Marco Pisanello, Marco Bianco

et al.

Biomedical Optics Express, Journal Year: 2021, Volume and Issue: 12(10), P. 6081 - 6081

Published: Aug. 31, 2021

Fiber photometry is widely used in neuroscience labs for vivo detection of functional fluorescence from optical indicators neuronal activity with a simple fiber. The fiber commonly placed next to the region interest both excite and collect signal. However, path excitation photons altered by uneven properties brain, due local variation refractive index, different cellular types, densities shapes. Nonetheless, effect anatomy on actual shape extent volume tissue that interfaces has received little attention so far. To fill this gap, we measured size efficiency field primary motor somatosensory cortex, hippocampus striatum mouse highlighting how their substructures determine detected signal depth at which can be mined. Importantly, show information spatial expression fluorescent probes alone not sufficient account contribution subregions overall collected signal, it must combined adjacent tip.

Language: Английский

Citations

12
PET imaging of kappa opioid receptors and receptor expression quantified in neuron-derived extracellular vesicles in socially housed female and male cynomolgus macaques DOI Open Access
Bernard Johnson, Ashish Kumar, Yixin Su

et al.

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 48(2), P. 410 - 417

Published: Sept. 13, 2022

Language: Английский

Citations

9
The Claustrum Controls Motor Activity Through Anterior Cingulate Cortex Input and Local Circuit Synchronization in a Preparatory Manner DOI

Zi-Qi Kou,

Chunyan Chen,

Mamatsali Abdurahman

et al.

Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 39(10), P. 1591 - 1594

Published: June 13, 2023

Language: Английский

Citations

5
Time to FIRE NORSE: A single acronym for a heterogeneous presentation. Further information from a case series and discussion of the literature. DOI
Abdulaziz Alaskar,

Majed Aljohani,

Sasha Dionisio

et al.

Journal of Neuroimmunology, Journal Year: 2024, Volume and Issue: 388, P. 578298 - 578298

Published: Jan. 26, 2024

Language: Английский

Citations

1
Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A DOI
Frederick A. Bagdasarian, Hanne D. Hansen,

Jingyuan Chen

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(14), P. 2654 - 2661

Published: June 25, 2024

The extent of changes in functional connectivity (FC) within networks as a common feature across hallucinogenic drug classes is under-explored. This work utilized fMRI to assess the dissociative hallucinogens Psilocybin, classical serotonergic psychedelic, and Salvinorin-A, kappa-opioid receptor (KOR) agonist, on resting-state FC nonhuman primates. We highlight overlapping differing influence these substances relative thalamus, claustrum, prefrontal cortex (PFC), default mode network (DMN), DMN subcomponents. Analysis was conducted within-subject basis. Findings support cortico-claustro-cortical model for probing effects regardless potential, with potential key paradigm centered around PFC, anterior cingulate cortices (ACC), angular gyrus relationship. Thalamo-cortical are implicated but appear dependent 5-HT2AR activation. Acute desynchronization both drugs also shown. Our findings provide framework understand broader mechanisms at which may impact subjects target receptor.

Language: Английский

Citations

1
Human Claustrum Connections: Robust In Vivo Detection by DWI‐Based Tractography in Two Large Samples DOI Creative Commons
Jil Wendt, Antonia Neubauer, Dennis M. Hedderich

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(14)

Published: Oct. 1, 2024

ABSTRACT Despite substantial neuroscience research in the last decade revealing claustrum's prominent role mammalian forebrain organization, as evidenced by its extraordinarily widespread connectivity pattern, claustrum studies humans are rare. This is particularly true for focusing on connections. Two primary reasons may account this situation: First, intricate anatomy of human located between external and extreme capsule hinders straightforward reliable structural delineation. In addition, few that used diffusion‐weighted‐imaging (DWI)‐based tractography could not clarify whether vivo consistently reliably identifies connections across different subjects, cohorts, imaging methods, metrics. To address these issues, we combined a recently developed deep‐learning‐based segmentation tool with DWI‐based two large adult cohorts: 81 healthy young adults from connectome project further participants Bavarian longitudinal study. Tracts 13 cortical 9 subcortical regions were reconstructed each subject using probabilistic tractography. Probabilistic group average maps metrics generated to assess profile well consistency replicability We found, individuals, DWI‐protocols, measures, consistent replicable ipsi‐ contralateral result demonstrates robust humans, providing base examinations health disease.

Language: Английский

Citations

1