The effect of high-intensity interval training on type 2 diabetic muscle: A metabolomics-based study DOI Creative Commons
Kayvan Khoramipour, Mohammad Amin Rajizadeh, Ziba Akbari

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e34917 - e34917

Published: July 20, 2024

BackgroundThis study aimed to investigate the effect of eight weeks high-intensity interval training (HIIT) on muscle metabolism in rats with type 2 diabetes (T2D) using metabolomics approaches.Methods20 male Wistar at age 8 weeks-were assigned four groups five, each group randomly: control (CTL), (DB), HIIT (EX), and + (DBX). T2D was induced by two months a high-fat diet plus single dose streptozotocin (35 mg/kg). Rats EX DBX performed (running 80–100 % Vmax, 4–10 intervals). NMR spectroscopy used determine changes metabolome profile after training.ResultsChanges metabolite abundance following exercise revealed distinct clustering multivariate analysis. The essential between DB CTL were arginine metabolism, purine phosphate pathway, amino sugar glutathione aminoacyl-tRNA biosynthesis. However, Arginine biosynthesis, pyrimidine alanine, aspartate, glutamate altered groups.ConclusionThese results suggest that could reverse metabolic rat muscles, contributing reduced FBG HOMA-IR levels.

Language: Английский

The effect of high-intensity interval training on type 2 diabetic muscle: A metabolomics-based study DOI Creative Commons
Kayvan Khoramipour, Mohammad Amin Rajizadeh, Ziba Akbari

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e34917 - e34917

Published: July 20, 2024

BackgroundThis study aimed to investigate the effect of eight weeks high-intensity interval training (HIIT) on muscle metabolism in rats with type 2 diabetes (T2D) using metabolomics approaches.Methods20 male Wistar at age 8 weeks-were assigned four groups five, each group randomly: control (CTL), (DB), HIIT (EX), and + (DBX). T2D was induced by two months a high-fat diet plus single dose streptozotocin (35 mg/kg). Rats EX DBX performed (running 80–100 % Vmax, 4–10 intervals). NMR spectroscopy used determine changes metabolome profile after training.ResultsChanges metabolite abundance following exercise revealed distinct clustering multivariate analysis. The essential between DB CTL were arginine metabolism, purine phosphate pathway, amino sugar glutathione aminoacyl-tRNA biosynthesis. However, Arginine biosynthesis, pyrimidine alanine, aspartate, glutamate altered groups.ConclusionThese results suggest that could reverse metabolic rat muscles, contributing reduced FBG HOMA-IR levels.

Language: Английский

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