The impact of methylphenidate on choice impulsivity is inversely associated with corpus callosum fiber integrity across sexes DOI Creative Commons
Maryana Daood, Leehe Peled‐Avron,

Rachel Ben‐Hayun

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121196 - 121196

Published: April 1, 2025

Choice impulsivity represents preference towards smaller immediate rewards over larger delayed rewards. Extensive literature demonstrates that choice can be manipulated using dopaminergic agonists such as methylphenidate (MPH), and females exhibit elevated compared to males. Sex differences are also frequently reported with respect brain white matter (WM) fiber integrity. It has yet determined whether sex exist in the impact of MPH on impulsivity, these putative accounted for by integrity differential WM fibers. Forty-eight healthy young adults completed delay discounting (DD) task twice during MRI-DTI scans after receiving either or placebo a double-blind, placebo-controlled, within-subject design. was assessed automated quantification (AFQ) tract-based spatial statistics (TBSS). Compared placebo, yielded significantly reduced males but not females. DTI data revealed multiple fibers Interestingly, negatively associated forceps major corpus callosum only positively minor only. Taken together, results uncover sex-specific effects inverse associations between under structural distinct segments callosum. These findings highlight need consider neurobiological mechanisms impulsivity.

Language: Английский

Single–dose methylphenidate induces shift in functional connectivity associated with positive longer term clinical response in adult attention–deficit/hyperactivity disorder DOI Creative Commons
Charlotte M. Pretzsch, Valeria Parlatini, Declan Murphy

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

Language: Английский

Citations

0
The impact of methylphenidate on choice impulsivity is inversely associated with corpus callosum fiber integrity across sexes DOI Creative Commons
Maryana Daood, Leehe Peled‐Avron,

Rachel Ben‐Hayun

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121196 - 121196

Published: April 1, 2025

Choice impulsivity represents preference towards smaller immediate rewards over larger delayed rewards. Extensive literature demonstrates that choice can be manipulated using dopaminergic agonists such as methylphenidate (MPH), and females exhibit elevated compared to males. Sex differences are also frequently reported with respect brain white matter (WM) fiber integrity. It has yet determined whether sex exist in the impact of MPH on impulsivity, these putative accounted for by integrity differential WM fibers. Forty-eight healthy young adults completed delay discounting (DD) task twice during MRI-DTI scans after receiving either or placebo a double-blind, placebo-controlled, within-subject design. was assessed automated quantification (AFQ) tract-based spatial statistics (TBSS). Compared placebo, yielded significantly reduced males but not females. DTI data revealed multiple fibers Interestingly, negatively associated forceps major corpus callosum only positively minor only. Taken together, results uncover sex-specific effects inverse associations between under structural distinct segments callosum. These findings highlight need consider neurobiological mechanisms impulsivity.

Language: Английский

Citations

0