Bidirectional modulation of Alzheimer’s disease via gut microbiota: rescue by fecal transplantation from healthy donors and aggravation by colitis-associated dysbiosis DOI Creative Commons

Chenglong Zhou,

Xin Feng, Huina Liu

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 23, 2025

Introduction Emerging evidence implicates gut microbiota dysbiosis as a key modulator for the pathogenesis of Alzheimer’s disease (AD) via gut-brain axis. To investigate causal role microbial communities in AD progression, we performed fecal transplantation (FMT) APP/PS1 transgenic mice using donor from healthy wild-type or dextran sulfate sodium (DSS)-induced colitis mice. Methods Cognitive function, amyloid-beta (Aβ) pathology, and pro-inflammatory cytokine levels were assessed 16S ribosomal RNA sequencing bioinformatic functional analyses applied to identify specific potentially involved progression. Results FMT-WT (fecal mice) exhibited significant improvements spatial memory (Morris Water Maze), exploratory behavior (Y-maze), locomotor activity (Open Field Test), alongside reduced Aβ plaque burden normalized expression cytokines (IL-6, IL-1β, TNF-α) both brain tissues. Conversely, FMT-DSS DSS-treated donors) displayed exacerbated cognitive deficits, heightened deposition, elevated levels. Microbial profiling revealed stark contrasts: harbored beneficial taxa ( Bacteroides , Lachnospiraceae ) linked anti-inflammatory products like short-chain fatty acid, while showed blooms pathogenic genera Erysipelatoclostridium Enterobacteriaceae associated with neurotoxic metabolites. Functional predicted enrichment neuroprotective pathways (e.g., lysine metabolism) carbon FMT-DSS. Crucially, neuroinflammation occurred independently barrier disruption, implicating circulating metabolites mediators. Discussion Our findings demonstrate that composition bidirectionally influences FMT donors attenuating colitis-associated exacerbates hallmarks. study positions microbiota-targeted therapies promising strategy modulate progression through

Language: Английский

Interplay of gut microbiota in Kawasaki disease: role of gut microbiota and potential treatment strategies DOI
Qing Yang,

Yaqing Kang,

Wei Tang

et al.

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Feb. 27, 2025

Kawasaki disease (KD) is an acute systemic immune vasculitis with predominant involvement of the medium and small arteries. It mostly affects pediatric patients, representing most common form in children less than 5 years old. Numerous diseases, especially those related to system, have established links intestinal flora. Recent studies investigated flora changes throughout management KD. There was gut microbiota dysbiosis KD at phase, particularly downregulation short-chain fat acids-producing over-proliferation opportunistic pathogens. The relationship between response therapies individuals specific remains uncertain. Targeted microbial supplements dietary regulation may serve as potential measures alleviate complications thus improve prognosis. This review provides overview current understanding interplay Furthermore, it discusses possibility altering reinstate a healthy condition.

Language: Английский

Citations

0
Advanced Biomarkers: Beyond Amyloid and Tau: Emerging Non-Traditional Biomarkers for Alzheimer’s Diagnosis and Progression DOI

Meher Rijwana Afrin,

P. Upadhyaya,

A. Hashim

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102736 - 102736

Published: March 1, 2025

Language: Английский

Citations

0
Bidirectional modulation of Alzheimer’s disease via gut microbiota: rescue by fecal transplantation from healthy donors and aggravation by colitis-associated dysbiosis DOI Creative Commons

Chenglong Zhou,

Xin Feng, Huina Liu

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 23, 2025

Introduction Emerging evidence implicates gut microbiota dysbiosis as a key modulator for the pathogenesis of Alzheimer’s disease (AD) via gut-brain axis. To investigate causal role microbial communities in AD progression, we performed fecal transplantation (FMT) APP/PS1 transgenic mice using donor from healthy wild-type or dextran sulfate sodium (DSS)-induced colitis mice. Methods Cognitive function, amyloid-beta (Aβ) pathology, and pro-inflammatory cytokine levels were assessed 16S ribosomal RNA sequencing bioinformatic functional analyses applied to identify specific potentially involved progression. Results FMT-WT (fecal mice) exhibited significant improvements spatial memory (Morris Water Maze), exploratory behavior (Y-maze), locomotor activity (Open Field Test), alongside reduced Aβ plaque burden normalized expression cytokines (IL-6, IL-1β, TNF-α) both brain tissues. Conversely, FMT-DSS DSS-treated donors) displayed exacerbated cognitive deficits, heightened deposition, elevated levels. Microbial profiling revealed stark contrasts: harbored beneficial taxa ( Bacteroides , Lachnospiraceae ) linked anti-inflammatory products like short-chain fatty acid, while showed blooms pathogenic genera Erysipelatoclostridium Enterobacteriaceae associated with neurotoxic metabolites. Functional predicted enrichment neuroprotective pathways (e.g., lysine metabolism) carbon FMT-DSS. Crucially, neuroinflammation occurred independently barrier disruption, implicating circulating metabolites mediators. Discussion Our findings demonstrate that composition bidirectionally influences FMT donors attenuating colitis-associated exacerbates hallmarks. study positions microbiota-targeted therapies promising strategy modulate progression through

Language: Английский

Citations

0