‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2287 - 2287

Published: Aug. 17, 2023

The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. production of ‘safe effective’ vaccines was a key public health target. Sadly, unprecedented high rates adverse events have overshadowed the benefits. This two-part narrative review presents evidence for widespread harms novel product mRNA adenovectorDNA is in attempting provide thorough overview arising from new technology that relied on human cells producing foreign antigen has pathogenicity. first paper explores peer-reviewed data counter attached these technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether SARS-CoV-2 virus or produced by vaccine gene codes, akin ‘synthetic virus’, increasingly understood terms molecular biology pathophysiology. Pharmacokinetic transfection through body tissues distant injection site lipid-nanoparticles viral-vector carriers means ‘spikeopathy’ can affect organs. inflammatory properties nanoparticles used ferry mRNA; N1-methylpseudouridine employed prolong synthetic function; biodistribution DNA codes translated spike proteins, autoimmunity via contribute harmful effects. reviews autoimmune, cardiovascular, neurological, potential oncological effects, autopsy spikeopathy. With gene-based therapeutic technologies planned, re-evaluation necessary timely.

Language: Английский

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Post-COVID-19 Era Forensics: Hospital Autopsies, New Methodologies, and Medicolegal Perspectives

Forensic Sciences, Journal Year: 2025, Volume and Issue: 5(1), P. 8 - 8

Published: Feb. 12, 2025

Background: Hospital autopsies, once considered fundamental to evidence-based medicine, have declined in many Western countries due legislative changes, faith-based objections, and inadequate funding public healthcare. However, the COVID-19 pandemic has revitalized interest their importance for determining cause of death generating health statistics. This study analyzes factors contributing this decline, with a focus on Italian context new medicolegal perspectives arising post-pandemic era. Methods: The research was conducted through an analysis 91 relevant scientific sources, including government documents, policy briefs, academic studies. Legislative regulatory influencing reduction hospital autopsies were examined, along technological that emerged following pandemic. Special attention given pandemic’s impact autopsy practices. Results: revealed perceived “low value” often stems from advancements, which led view these procedures as redundant. post-COVID-19 era, there been renewed awareness value significant implications statistics evolution forensic medicine. Conclusions: highlighted vital role delivering accurate medical information, prompting Moving forward, will need balance innovations traditional practices, paving way medicine data management.

Language: Английский

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Serum Lactate Dehydrogenase Levels Reflect the Lung Injury Extension in COVID‐19 Patients at Hospital Admission

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Background Several hematological and biochemical parameters have been related to the COVID‐19 infection severity outcomes. However, less is known about clinical indicators reflecting lung involvement of patients at hospital admission. Computed tomography (CT) represents an established imaging tool for detection injury, quantitative analysis software CALIPER has used assess in patients. Herein, relationship between expressed by interstitial disease (ILD) percentage a set blood tissue oxygenation damage admission was evaluated. Methods We performed retrospective prospective study involving 321 75, respectively, COVID‐19‐positive recruited from Pisa University Hospital. The association ILD percentages selected investigated regression tree approach, after multiple imputations dataset missing values. Results High serum lactate dehydrogenase (LDH) values appeared be predictive high both datasets, even if performance algorithm not optimal. Conclusions LDH levels could evaluated as early identification risk extensive well fast screening procedures before hospitalization.

Language: Английский

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ORCHESTRA Delphi Consensus: diagnostic and therapeutic management of SARS-CoV-2 infection in haematological patients

Clinical Microbiology and Infection, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Clinical features and outcomes in adults with COVID-19 during the pre-Omicron and Omicron waves

Infectious Diseases Now, Journal Year: 2023, Volume and Issue: 54(2), P. 104833 - 104833

Published: Nov. 15, 2023

Language: Английский

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Risk factors for SARS-CoV-2 pneumonia among renal transplant recipients in Omicron pandemic—a prospective cohort study

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 4, 2024

The coronavirus disease (COVID-19) pandemic is a global health emergency, and SARS-CoV-2 pneumonia poses significant challenges to systems worldwide. Renal transplant recipients (RTRs) are special group more vulnerable viral pneumonia. However, few studies have elucidated the risk factors of in RTRs infected with COVID-19. This study aimed build prediction model for among based on demographic clinical information. We conducted prospective cohort 383 (age ≥ 18 years) diagnosed COVID-19 from December 21, 2022, March 26, 2023. Patients' information was collected through questionnaire survey combined electronic medical records. A stepwise logistic regression established test predictors assessed diagnostic performance by calculating area under curve (AUC) receiver operating characteristic (ROC) calibration using Hosmer-Lemeshow (HL) goodness-of-fit test. Our showed that incidence 31.1%. Older age (OR = 2.08-3.37,95%CI:1.05-7.23), shorter post-transplantation duration 0.92,95% CI: 0.87,0.99), higher post-transplant Charlson Comorbidity Index (CCI) 1.84, 95%CI: 1.14,2.98), pulmonary infection history 3.44, 1.459, 8.099, P 0.005), fatigue 2.11, 1.14, 3.90), cough 2.03, 1.08, 3.81), lower estimated glomerular filtration rate (eGFR) at diagnosis 0.98, 95%CI:0.97,0.99) predicted good Chi-Square 10.832 (P > 0.05) AUC 0.839 < 0.001). high RTRs, we built patients' characteristics. can help identify inform timely, targeted, effective prevention intervention efforts.

Language: Английский

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Human monoclonal antibody F61 nasal spray effectively protected high-risk populations from SARS-CoV-2 variants during the COVID-19 pandemic from late 2022 to early 2023 in China

Emerging Microbes & Infections, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 16, 2023

Following the national dynamic zero-COVID strategy adjustment, utilization of broad-spectrum nasal neutralizing antibodies may offer alternative approach to controlling outbreak Omicron variants between late 2022 and early 2023 in China. This study involved an investigator-initiated trial (IIT) assess pharmacokinetic, safety efficacy F61 spray. A total 2,008 participants were randomly assigned receive spray (24 mg/0.8 mL/dose) or normal saline (0.8 1,336 completed follow-up IIT. Minimal absorption antibody into bloodstream was detected individuals receiving for seven consecutive days. No treatment-emergent adverse reactions grade 3 severity higher reported. In one-dose cohort, 7-day cumulative SARS-CoV-2 infection rate 79.0% group 82.6% placebo group, whereas, multiple-dose (once daily 7 days) rates 6.55% 23.83% group. The laboratory-confirmed 3.78% (-3.74%–10.75%) cohort 72.19% (57.33%–81.87%) cohort. real-world study, 60,225 volunteers four different regions administered based on subject's wishes, over 90% observed against variants. spray, with its favorable profile, could be a promising prophylactic monoclonal VOCs.

Language: Английский

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Effects of the response to the COVID-19 pandemic in chest trauma patients in China: a multicenter retrospective study

Journal of Cardiothoracic Surgery, Journal Year: 2023, Volume and Issue: 18(1)

Published: Nov. 30, 2023

Abstract Background An international pandemic of severe coronavirus disease (COVID-19) has been caused by the novel SARS-CoV-2. A large number patients with chest trauma were infected COVID-19. The COVID-19 had a significant impact on management trauma. Objective present observational study was conducted to evaluate clinical characteristics and outcomes or without infection. Methods multicenter performed at three Chinese hospitals between November 1, 2022, January 31, 2023. All enrolled diagnosed We analyzed data from existing medical records, including all baseline prognostic follow-up data, such as 30-day mortality, hospital stays, hospitalization costs, complications. Results 375 eligible completed follow-up. There no difference in combined ( p > 0.05). Chest infection may lead higher mortality (16.36% vs. 7.14%, = 0.005), longer stays (22.5 ± 5.9 12.8 4.2, < 0.001), larger costs increased complications, pulmonary embolism (10.30% 4.76%, 0.039), deep vein thrombosis (DVT, 33.33% 18.57%, incidence 7-day delirium (69.70% 46.19%, respiratory failure (38.18% 24.77%, 0.005). Conclusions Compared alone, it more To better respond future other similar virus-borne pandemics, is important understand embolism, DVT, after guide treatment infectious diseases.

Language: Английский

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The clinical features of severe COVID-19 with respiratory failure: A Chinese single-center retrospective study

Medicine, Journal Year: 2023, Volume and Issue: 102(48), P. e36110 - e36110

Published: Dec. 1, 2023

The global pandemic of COVID-19, caused by the novel coronavirus SARS-CoV-2, has resulted in widespread alterations to public health measures worldwide. This observational study aimed assess clinical features and results respiratory failure patients with severe COVID-19. A single-center was performed at a Chinese hospital between November 1, 2022, February 31, 2023. All 182 enrolled were diagnosed failure, 84 infected other 98 not infected. review available medical records admission discharge, including neuroimaging, laboratory values admission, mortality, length hospitalization, costs, conducted during COVID-19 pandemic. eligible completed follow-up. There no significant difference baseline characteristics combined (P > .05). Respiratory infection may lead higher 30-day mortality (16.36% vs 7.14%, P = .005), longer stays (22.5 ± 5.9 12.8 4.2, < .001), larger hospitalization costs increased complications, such as pulmonary embolism (10.30% 4.76%, .039), deep vein thrombosis (33.33% 18.57%, incidence 7-day delirium (69.70% 46.19%, (38.18% 24.77%, .005). If occurs while patient is treatment prognosis worsen. Our understanding care we provide crucial better prepare for potential

Language: Английский

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