Current landscape and future directions of therapeutic approaches for adenoid cystic carcinoma of the salivary glands (Review)

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(3)

Published: Jan. 22, 2025

Adenoid cystic carcinoma (ACC) of the salivary glands is second most common type gland cancer, and characterized by a poor prognosis an unclear pathology. The incidence ACC rare, as it accounts for 10-15% all tumors affects mainly patients aged between 50 60 years. annual rate estimated to be ~4.5 cases per 100,000 individuals. Due its rarity use contaminated cell lines in previous investigations, precise etiological factors underlying remain poorly understood. Current treatment modalities, typically involving surgery with or without postoperative radiotherapy, often prove unsatisfactory due potential local recurrence delayed distant metastases, which may manifest 3-5 years after constitute primary failure existing therapeutic approaches. indolent growth pattern, along perineural perivascular invasion, potentially responsible onset metastases. No effective systemic therapy has been established so far. Therefore, management represents significant challenge. Exploring molecular characteristics ACC, including reasons behind propensity invasion correlation immune system, offers promising strategies managing could open up novel pathways future interventions. Currently, immunotherapy shown limited effectiveness. While exact mechanism lack response remains unknown, low levels tumor-infiltrating lymphocytes these contribute this resistance. identifying targets enhance against tumor cells essential. present review provides update on clinical studies explores that ACC.

Language: Английский

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Primary pulmonary adenoid cystic carcinoma: A study of clinicopathological features and molecular alterations in twenty-one cases

Lung Cancer, Journal Year: 2025, Volume and Issue: 201, P. 108414 - 108414

Published: Jan. 31, 2025

Language: Английский

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Diagnosis of pulmonary adenoid cystic carcinoma using multimodal ultrasound imaging technology: A case report

Medicine, Journal Year: 2025, Volume and Issue: 104(1), P. e41212 - e41212

Published: Jan. 3, 2025

Pulmonary adenoid cystic carcinoma (PACC) is an exceedingly uncommon malignant tumor originating from salivary glands. We present a case of primary PACC with multiple lung metastases in 48-year-old male patient. Diagnosis involved grayscale ultrasound, shear wave elastography, contrast-enhanced and ultrasound-guided percutaneous biopsy, all conducted one-stop manner, confirmed by pathological examination. Treatment was recommended after the diagnosis confirmed, but not accepted. With telephone follow-up, patient survived. Compared to other cases, this highlights potential multimodal ultrasound imaging for diagnosing tumors.

Language: Английский

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A Comprehensive Review of Advances in Molecular Mechanisms and Targeted Therapies for the Specific Type of Cystic Lung Cancer

OncoTargets and Therapy, Journal Year: 2025, Volume and Issue: Volume 18, P. 211 - 224

Published: Feb. 1, 2025

Background and Objective: Cystic lung cancer (CLC) presents diagnostic treatment challenges due to its complex imaging features unclear molecular mechanisms. Although surgery standard chemotherapy are frequently used, there is limited information on targeted therapy other precision treatments. It crucial comprehensively understand the mechanisms explore treatments based therapy. Methods: Topic keywords including "CLC", "cystic cancer", "cavitary "Lung associated with cystic airspaces", "lung cancer" ("sac cavity" OR degeneration" "thin-walled "adenocystic carcinoma" airspaces" "pulmonary cysts" "adenoid carcinoma") searched in relevant databases, such as PubMed, Google Scholar, CNKI (China National Knowledge Infrastructure). Then, we reviewed analyzed mechanism therapeutics of CLC. Key Content Findings: Various subtypes CLC can be identified through histopathological examination, adenocarcinoma, squamous cell carcinoma. However, still have much learn about behind Gene mutation, abnormal tumor microenvironment, immune dysfunction main mechanisms, along potential factors like epigenetic modifications gene susceptibility related COPD. Recent advancements include therapies, inhibitors for EGFR, ALK, ROS1, BRAF, MET. Surgical treatment, standardized chemotherapy, immunotherapy, combination remain important. Future research should focus genomic profiling, development medicine insights into heterogeneity Additionally, investigating resistance developing predictive biomarkers important future research. Conclusion: The key involve mutations TME dysfunction. requires comprehensive staging, has shown significant advantages prospects. Keywords: pathogenesis, mechanism, therapy, therapeutics,

Language: Английский

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Two rare primary tumours of the thymus with differential immunohistochemical characterisation and a potential new entity

Diagnostic histopathology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Molecular genetic profiling of a rare case of primary pulmonary adenoid cystic carcinoma: Insights from whole exome sequencing and literature review

Respiratory Medicine Case Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102198 - 102198

Published: March 1, 2025

Primary pulmonary adenoid cystic carcinoma (PPACC) is a rare neoplasm characterized by slow growth and low malignancy. The study seeks to enhance understanding of PPACC through comprehensive analysis reported case, incorporating pathological diagnosis, immunohistochemistry, special staining, molecular alterations identified via whole exome sequencing. A retrospective was conducted on case treated at the institution, encompassing examination, immunohistochemical profiling, staining techniques, revealed 56-year-old male presented with left lower lobe mass chest CT during routine health check. Clinical evaluation dyspnea, imaging showed 25 × 18 mm nodule in lobe. Video-assisted thoracoscopic surgery performed for lobectomy, intraoperative frozen pathology indicating salivary gland-type tumor (2.5 2 1.7 cm). ENT examination cervical MRI ruled out primary gland tumor. Routine paraffin-embedded confirmed without pleural invasion. Whole sequencing mutations MYB family genes ALK gene. This highlights characteristics PPACC, including cribriform pattern specific genetic mutations. These findings underscore necessity enhancing clinical vigilance avoid misdiagnosis missed diagnosis this disease.

Language: Английский

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Treatment outcomes of single-fraction stereotactic radiosurgery for adenoid cystic carcinoma: a case series of 55 patients

Journal of Neuro-Oncology, Journal Year: 2024, Volume and Issue: 166(2), P. 369 - 376

Published: Jan. 1, 2024

Language: Английский

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Revolutionizing Lung Cancer Treatment with Smart Pulmonary Drug Delivery Nanosystems

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106158 - 106158

Published: Sept. 6, 2024

Language: Английский

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Current diagnosis and treatment of salivary gland-type tumors of the lung

Japanese Journal of Clinical Oncology, Journal Year: 2023, Volume and Issue: 54(3), P. 229 - 247

Published: Nov. 28, 2023

Abstract Salivary gland-type tumors of the lung are thought to originate from submucosal exocrine glands large airways. Due their rare occurrence, reports study limited small-scale or case reports. Therefore, daily clinical practices often require a search for previous In last 20 years, several genetic rearrangements have been identified, such as MYB::NF1B in adenoid cystic carcinoma, CRTC1::MAML2 mucoepidermoid EWSR1::ATF1 hyalinizing clear cell carcinoma and EWSR1 locus FUS (TLS) myoepithelioma myoepithelial carcinoma. These molecular alterations useful diagnosing these tumors, although they not yet linked molecularly targeted therapies. The morphologic, immunophenotypic, characteristics similar those counterparts extrapulmonary origin, so radiologic differential diagnosis is required distinguish between primary metastatic disease other sites. However, can be differentiating them cancer histologic types. management requires broad knowledge latest diagnostics, surgery, radiotherapy, bronchoscopic interventions, chemotherapy, immunotherapy well therapeutic agents development, including agents. This review provides comprehensive overview current treatment pulmonary salivary gland with focus on which two most common subtypes.

Language: Английский

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Rare but clinically important salivary gland-type tumor of the lung: A review

Japanese Journal of Clinical Oncology, Journal Year: 2023, Volume and Issue: 54(2), P. 121 - 128

Published: Nov. 10, 2023

Abstract Salivary gland-type tumor (SGT) of the lung, which arises from bronchial glands tracheobronchial tree, was first recognized in 1950s. SGT represents less than 1% all lung tumors and is generally reported to have a good prognosis. Mucoepidermoid carcinoma (MEC) adenoid cystic (ACC) are two most common subtypes, comprising more 90% SGTs. The 5-year survival rate patients with 63.4%. Because this type develops major bronchi, commonly present symptoms obstruction, including dyspnea, shortness breath, wheezing, coughing; thus, usually identified at an early stage. Most treated by lobectomy pneumonectomy, but bronchoplasty or tracheoplasty often needed preserve respiratory function. Lymphadenectomy surgical resection recommended, given that clinical benefit lymphadenectomy has been MEC. For advanced tumors, appropriate therapy should be considered according subtype because varying clinicopathologic features. MEC, not ACC, likely radiation its low response rate. Although previous researchers learned much studying over years, diagnosis treatment remains complex challenging problem for thoracic surgeons. In article, we review diagnosis, prognosis, (surgery, chemotherapy, radiotherapy) SGT, mainly focusing on MEC ACC. We also summarize reports adjuvant definitive ACC literature.

Language: Английский

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