Impact of Maternal Exposure to SARS-CoV-2 on Immunological Components of Breast Milk
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2600 - 2600
Published: March 13, 2025
COVID-19,
caused
by
SARS-CoV-2,
has
become
a
global
public
health
threat.
Although
no
replication-competent
virus
been
found
in
breast
milk
samples,
breastfeeding
practices
during
the
pandemic
were
impacted.
It
is
well
known
that
adapted
to
meet
needs
of
infants,
providing
appropriate
amounts
nutrients
and
various
bioactive
compounds
contribute
maturation
immune
system
antioxidant
protection,
safeguarding
infants
against
diseases.
While
its
composition
variable,
contains
cells,
antibodies,
cytokines,
which
have
anti-inflammatory,
pro-inflammatory,
antiviral,
antibacterial
properties
strengthen
infant
immunity.
Since
COVID-19
vaccines
not
yet
approved
for
under
six
months
age,
newborns
rely
on
passive
transfer
antibodies
via
placenta
protect
them
severe
SARS-CoV-2
infection.
Several
studies
analyzed
samples
context
demonstrated
strong
antibody
response
induced
following
maternal
infection
with
SARS-CoV-2.
Therefore,
this
review
aims
provide
comprehensive
overview
impact
exposure
through
natural
and/or
vaccination
immunological
based
conducted
topic.
Language: Английский
Factors Influencing Breast Milk Antibody Titers during the Coronavirus Disease 2019 Pandemic: An Observational Study
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2320 - 2320
Published: July 18, 2024
The
COVID-19
pandemic
has
highlighted
the
role
of
breastfeeding
in
providing
passive
immunity
to
infants
via
specific
anti-SARS-CoV-2
antibodies
breast
milk.
We
aimed
quantify
these
across
different
lactation
stages
and
identify
influencing
factors.
This
prospective
study
involved
mother-child
dyads
from
Innsbruck
University
Hospital,
Austria,
with
a
positive
maternal
SARS-CoV-2
test
during
pregnancy
or
peripartum
between
2020
2023.
collected
milk
samples
at
various
analyzed
anti-Spike
S1
receptor-binding
domain
(S1RBD)
immunoglobulins
(Ig).
Maternal
neonatal
data
were
obtained
interviews
medical
records.
included
140
mothers
144
neonates.
Anti-S1RBD-IgA
(72.0%),
-IgG
(86.0%),
-IgM
(41.7%)
highly
present
colostrum
decreased
as
matured.
Mothers
natural
infection
vaccination
exhibited
higher
anti-S1RBD-IgA
titers
all
stages.
moderate
severe
infections
had
concentrations
transitional
mature
compared
those
mild
asymptomatic
infections.
Variations
antibody
responses
also
observed
preterm
birth
virus
waves.
demonstrates
dynamic
nature
Ig
underscores
importance
pandemic.
Language: Английский