Reducing clinical target volume margins for multifocal glioblastoma: a multi-institutional analysis of patterns of recurrence and treatment response DOI Open Access
Francesco Marampon, Giovanni Luca Gravina,

Elisa Cinelli

et al.

Radiation Oncology Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

No guidelines exist to delineate radiation therapy (RT) targets for the treatment of multiple glioblastoma (mGBM). This study analyzes margins around gross tumor volume (GTV) create a clinical target (CTV), comparing response parameters and modalities recurrence. One-hundred three mGBM patients with CTV margin 2 cm (GTV + 2.0 cm) or 1 1.0 were retrospectively analyzed. All received total dose 59.4-60 Gy in 1.8-2.0 daily fractions, delivered from 4 8 weeks after surgery, concomitantly temozolomide (75 mg/m2). Overall survival (OS) progression-free (PFS) calculated date surgery until diagnosis disease progression performed by magnetic resonance imaging classified as marginal, in-field, distant, site distribution RT plan. OS CTV1 group was 11.2 months (95% confidence interval [CI], 10.3-12.1), 9.2 CTV2 CI, 9.0-11.3). PFS occurred within 8.3 7.3-9.3), 7.3 6.4-8.1). difference observed between two groups terms time distribution. Adjusted multivariate Cox risk model, epidermal growth factor receptor amplification resulted negative prognostic both PFS. In mGBM, use expansion seems feasible it does not significantly affect oncological outcomes outcome.

Language: Английский

The effect of radiation dose to the brain on early self-reported cognitive function in brain and head-and-neck cancer patients DOI Creative Commons

Femke Vaassen,

David Hofstede, Catharina M.L. Zegers

et al.

Clinical and Translational Radiation Oncology, Journal Year: 2025, Volume and Issue: 52, P. 100929 - 100929

Published: Feb. 8, 2025

Language: Английский

Citations

0
Clinical significance of cerebral microbleeds in patients with germinoma who underwent long-term follow-up DOI Creative Commons
Masayuki Kanamori, Shunji Mugikura, Osamu Iizuka

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Purpose This study identified the factors affecting cerebral microbleed (CMBs) development. Moreover, their effects on intelligence and memory association with stroke in patients germinoma who had long-term follow-up were evaluated. Methods Patients histologically clinically diagnosed treated for included this analysis. These evaluated cross-sectionally, a focus CMBs susceptibility-weighted magnetic resonance imaging (SWI) memory. Results The period was from 32 to 412 (median: 175.5) months. In total, 46 (72%) CMB. total number of 523 (8.1 per patient). recurrence significantly higher based analysis covariance adjusted intervals initial treatment acquisition images. ༴he classified into CMB-high CMB-low groups median high CMB lower processing speed score than those low Before SWI during periods, eight strokes occurred four patients. Greater 15 found all Meanwhile, 51 < 14 did not experience stroke. Conclusion longer time initiation CMBs. Further, increased over time, significant risk factor Finally, related decline process onset.

Language: Английский

Citations

0
Growth hormone receptor antagonist pegvisomant and its role in the medical therapy of growth hormone excess DOI Creative Commons
James MacFarlane, Márta Korbonits

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 38(4), P. 101910 - 101910

Published: June 29, 2024

Pegvisomant is a growth-hormone (GH) receptor antagonist that prevents the formation of active heterotrimer dimerised GH and molecule necessary for downstream signal transduction. Over past 20 years, it has become key therapeutic option physicians treating syndromes GH/IGF-1 excess. Sufficient longitudinal follow-up data suggest can be deemed both safe effective. It drug with greatest potential achieving an amelioration biochemical effects excess corresponding normalisation IGF-1 levels; however, insufficient dose titration lessened real-world outcomes. Theoretical concerns about stimulating tumour growth have been resolved as this not observed, while derangement liver enzymes local skin-related adverse reactions may occur in minority patients. particularly impactful medication treatment children, young people, those inherited disorders excess, where other modalities often fail. Combination therapy pegvisomant first- second-generation somatostatin ligands or dopamine agonists remains ongoing area interest research. High cost barrier to use many settings.

Language: Английский

Citations

0
Hypothalamic-Pituitary Axis Dysfunction after Radiotherapy for Brain, Head and Neck and Skull Base Tumors – a Systematic Review and Meta-Analysis DOI

J. Paulissen,

Catharina M.L. Zegers, Ruud Houben

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Clinical significance of cerebral microbleeds in patients with germinoma who underwent long-term follow-up DOI Creative Commons
Masayuki Kanamori, Shunji Mugikura, Osamu Iizuka

et al.

Journal of Neuro-Oncology, Journal Year: 2024, Volume and Issue: 170(1), P. 173 - 184

Published: Aug. 12, 2024

Abstract Purpose This study identified the factors affecting cerebral microbleed (CMBs) development. Moreover, their effects on intelligence and memory association with stroke in patients germinoma who had long-term follow-up were evaluated. Methods included 64 histologically clinically diagnosed treated for germinoma. These evaluated cross-sectionally, a focus CMBs susceptibility-weighted magnetic resonance imaging (SWI), brain atrophy assessed through volumetric analysis, memory. Results The period was from 32 to 412 (median: 175.5) months. In total, 43 (67%) 509 21 did not have CMBs. Moderate correlations observed between number of time initial treatments recurrence found be risk factor CMB Increased temporal marginal effect processing speed visual memory, whereas statistically significant verbal, visual, general speed. Before SWI acquisition during periods, eight strokes occurred four patients. All these ≥ 15 before onset. Meanwhile, 33 < 14 or without experience stroke. Conclusion Patients longer treatment initiation higher CMBs, Furthermore, stronger than predict

Language: Английский

Citations

0
Radiotherapy-induced Hypothalamic-Pituitary axis dysfunction in adult Brain, head and neck and skull base tumor patients – A systematic review and Meta-Analysis DOI Creative Commons

J. Paulissen,

C.M.L. Zegers,

Ruud Houben

et al.

Clinical and Translational Radiation Oncology, Journal Year: 2024, Volume and Issue: 51, P. 100900 - 100900

Published: Dec. 14, 2024

Language: Английский

Citations

0
Reducing clinical target volume margins for multifocal glioblastoma: a multi-institutional analysis of patterns of recurrence and treatment response DOI Open Access
Francesco Marampon, Giovanni Luca Gravina,

Elisa Cinelli

et al.

Radiation Oncology Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

No guidelines exist to delineate radiation therapy (RT) targets for the treatment of multiple glioblastoma (mGBM). This study analyzes margins around gross tumor volume (GTV) create a clinical target (CTV), comparing response parameters and modalities recurrence. One-hundred three mGBM patients with CTV margin 2 cm (GTV + 2.0 cm) or 1 1.0 were retrospectively analyzed. All received total dose 59.4-60 Gy in 1.8-2.0 daily fractions, delivered from 4 8 weeks after surgery, concomitantly temozolomide (75 mg/m2). Overall survival (OS) progression-free (PFS) calculated date surgery until diagnosis disease progression performed by magnetic resonance imaging classified as marginal, in-field, distant, site distribution RT plan. OS CTV1 group was 11.2 months (95% confidence interval [CI], 10.3-12.1), 9.2 CTV2 CI, 9.0-11.3). PFS occurred within 8.3 7.3-9.3), 7.3 6.4-8.1). difference observed between two groups terms time distribution. Adjusted multivariate Cox risk model, epidermal growth factor receptor amplification resulted negative prognostic both PFS. In mGBM, use expansion seems feasible it does not significantly affect oncological outcomes outcome.

Language: Английский

Citations

0