Antimicrobial Resistance: Linking Molecular Mechanisms to Public Health Impact

SLAS DISCOVERY, Journal Year: 2025, Volume and Issue: unknown, P. 100232 - 100232

Published: April 1, 2025

Antimicrobial resistance (AMR) develops into a worldwide health emergency through genetic and biochemical adaptations which enable microorganisms to resist antimicrobial treatment. β-lactamases (blaNDM, blaKPC) efflux pumps (MexAB-OprM) working with mobile elements facilitate fast proliferation of multidrug-resistant (MDR) exttreme drug-resistant (XDR) phenotypes thus creating major concerns for healthcare systems community as well the agricultural sector. The review dissimilarly unifies molecular pathways public implications study epidemiological data monitoring approaches innovative therapeutic solutions. Previous studies separating their attention between genetics clinical outcomes have been combined our approach delivers an all-encompassing analysis AMR. report investigates mechanisms feature enzymatic degradation pump overexpression together target modification horizontal gene transfer because these factors represent important contributors present-day AMR developments. This effects on hospital environments where it affects pathogens including MRSA, carbapenem-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa. document explores modern management methods that comprise WHO GLASS surveillance three strategies such CRISPR-modified genome editing bacteriophage treatments along peptides artificial intelligence diagnostic tools. resolution needs complete scientific global operational alongside state-of-the-art approaches. Worldwide infection burden requires both enhanced prevention procedures next-generation reduce cases effectively.

Language: Английский

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SAGES white paper on antibiotic omission in the management of acute uncomplicated diverticulitis: why, when, who, and most importantly, how

Surgical Endoscopy, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

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Prevalence of Self-Medication and Associated Factors among Healthcare Students during the COVID-19 Pandemic: A Cross-Sectional Study at the University of Zambia

Open Journal of Social Sciences, Journal Year: 2023, Volume and Issue: 11(10), P. 340 - 363

Published: Jan. 1, 2023

Background: The global effects of COVID-19 on individuals worsened the problem self-medication (SM), a driver antimicrobial resistance (AMR). In Zambia, there is little information documented prevalence SM among students during pandemic. Aim: This study assessed and associated factors healthcare at University Zambia. Materials Methods: descriptive cross-sectional was conducted 323 using structured questionnaire. Data analysis done SPSS version 23.0. Statistical significance 95% confidence level. Binary logistic regression used to determine that were with self-medication. Results: Of participants, 51.4% female 67.8% from program pharmacy. paracetamol (36.5%), azithromycin (19.3%), chlorpheniramine (13.6%) being most medicines. common conditions experienced included headaches (22.6%), sneezing (13.6%), fever (8.7%), coughing/sneezing (5.6%). practices due fear contracting facilities (21.4%), time-consuming (19.2%), knowledge medicines acquired in school (18.9%). Older students, aged between 34 50 years less likely practice compared those who younger (OR = 0.068, CI: 0.015 - 0.304). Furthermore, aware more than not 32.866, 7.751 139.525). Conclusion: found high awareness painkillers, antibiotics, anti-allergies overused treat symptoms. overuse misuse antibiotics may lead resistance, thus need promote stewardship even universities. There rational use other future public health emergencies.

Language: Английский

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Mechanism-guided strategies for combating antibiotic resistance

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(10)

Published: Aug. 10, 2024

Language: Английский

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Antimicrobial resistance: Current challenges and future directions

Medical Journal Armed Forces India, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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