
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 4, 2025
Background Gastroesophageal Reflux Disease (GERD), a prevalent gastrointestinal disorder globally, exhibits variable prevalence across regions, with higher frequencies observed in Western nations and lower Asian countries. Key contributing factors encompass unhealthy eating patterns, tobacco use, consumption of alcohol, excess weight, obesity, along health conditions such as gestation diabetes. Common manifestations include heartburn burning discomfort behind the breastbone, which, without appropriate management, can progress to more severe issues like esophagitis Barrett’s esophagus. Approaches management prevention primarily involve modifications lifestyle, pharmacotherapy, surgical interventions when deemed necessary. Utilizing Omics Mendelian Randomization (OMR) investigate causative links between genetic variants diseases provides insights into biological underpinnings gastroesophageal reflux diseasec. It aids pinpointing novel targets for therapy. The influence amino acids disease demonstrates complexity, having potential both mitigate intensify symptoms, underscoring significance personalized nutrition therapeutic strategies. Methods This study is based on omics mendelian randomization method, coupled meta-analysis techniques, enhance precision research findings. Furthermore, reverse validation procedure was implemented validate association positive findings outcomes further. Throughout study, multiple correction measures were employed ensure accuracy reliability results. Results Based our methodology, we have ultimately discovered that glutamate exacerbates disease, increasing its risk. data supporting this includes analysis 20 from Finnish database, which showed had an odds ratio (OR) risk 1.175(95% confidence interval (CI): 1.000 ~ 1.380, P = 0.05), beta value 0.161. Analysis UK database indicated OR 1.399(95% CI: 1.060 1.847, 0.018) 0.336. After conducting MR results applying corrections, combined 1.227 (95% 1.068 1.411 0.043); values three primary consistent direction. Building results, outcome two different sources showed: Finngen exposure, Inverse Variance Weighted (IVW) method resulted P-value 0.059; IEU under same condition, IVW 1.433. Conclusions Glutamate may increase exacerbate progression through mechanisms impacting nervous system promoting inflammatory responses. Delving role enriches understanding disease’s offer new strategies clinical treatment nutritional management. insight aid developing healthier dietary plans, thereby benefiting patients.
Language: Английский
Citations
0Zeitschrift für Orthopädie und Unfallchirurgie, Journal Year: 2024, Volume and Issue: unknown
Published: March 8, 2024
Zusammenfassung Eine schmerzhafte Reduktion der Beweglichkeit Schulter, die als „Schultersteife“ bekannt ist, kann sowohl primär idiopathisch auftreten auch sekundär, bspw. Folge chirurgischer Eingriffe. Es existieren verschiedene Faktoren, zur Entstehung primären Schultersteife beitragen können. Daher fasst diese Übersichtsarbeit pathophysiologische Mechanismen, genetische Einflüsse, endokrinologische Störungen, metabolische Krankheitsbilder sowie andere Erkrankungen und medizinisch-therapeutische Ansätze zusammen, möglicherweise einen Einfluss auf Entwicklung haben könnten.
Citations
0Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Nov. 13, 2024
Objective This study aimed to investigate the causal relationship between insomnia and risk of myocardial infarction (MI) explore potential mediators such as smoking initiation, alcohol consumption body mass index (BMI) using mendelian randomization (MR) analysis. Methods Data from 1,207,228 individuals European ancestry were obtained UK Biobank 23andMe for insomnia-related genetic associations. Genetic instruments MI, consumption, BMI derived large-scale genome-wide association studies. Univariate MR analysis mainly utilized inverse variance weighting method, multivariable assessed mediation effects initiation BMI. Results The univariate revealed a 96% increased MI in with [odds ratio (OR) = 1.96; 95% CI: 1.67, 2.31]. Smoking identified mediators. indicated accounted 29% total effect (95% 13%, 61%), while 15% 7%, 27%), combined proportion 54% 31%, 91%). Conclusions results this demonstrate that increases MI. Quitting losing weight may reduce risk; however, there is still portion impact on cannot be explained. Therefore, further investigation into other potentially modifiable intermediate factors necessary.
Language: Английский
Citations
0Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Language: Английский
Citations
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