Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 13, 2025

Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains challenge. Our study aims investigate the relationship between and Systemic Immune-Inflammation Index (SII), comprehensive indicator of inflammation. This cross-sectional enrolled 632 patients. All participants underwent geriatric assessment. Sarcopenia was assessed through evaluation handgrip strength calf circumference. To determine SII, we used formula: Platelet count (109/mm3)×Neutrophil (109/mm3) / Lymphocyte (109/mm3). The average age 74.8 ± 6.4, 62.3% (n = 394) were female. Patients grouped non-sarcopenic sarcopenic. group had 536 patients (84.8%), while sarcopenic comprised 96 (15.2%). Sarcopenic showed higher median SII score than (p < 0.001). Multivariate logistic regression analysis revealed that significantly independently associated with even after adjusting for potential confounding factors (β 1.002, 95% CI 1.001–1.003, p ROC identified optimal cut-off in predicting > 765. At this threshold, negative predictive values determined be 88.1%, specificity 88%. outpatient population, population-specific may serve novel, simple, practical biomarker diagnosing sarcopenia.

Language: Английский

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Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

Primary sarcopenia is characterized by a progressive loss of skeletal muscle mass, strength, and physical function that occurs with aging. Despite the related adverse or even serious health outcomes, no medications are currently available for treating primary sarcopenia. Here, we discuss recent advancements in understanding mechanistic role gut microbiota-muscle cross-talk sarcopenia, therapeutic implications. The insights encompass causal dysbiosis potentially mediated through microbiota-derived bioactive metabolites, such as short-chain fatty acids (SCFAs), secondary bile acids, their associated signaling pathways, which may be translated into development new microbiome-based treatment diagnostic approaches. Furthermore, identify challenges need addressing future studies to facilitate translation potential novel differential diagnosis older individuals

Language: Английский

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Age difference in the connection between systemic inflammatory response and metabolic syndrome

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Background This research aims to investigate the connection between systemic inflammatory response and metabolic syndrome (MetS) across different age groups, with aim of proposing more targeted recommendations. Methods study enrolled 15 959 adults from 2001-2018 National Health Nutrition Examination Survey whom 6739 were diagnosed MetS. After dividing immune-inflammation index (SII) into 4 quartiles, Kruskal–Wallis test weighted chi-square employed assess statistical differences. Weighted multivariable logistic regression analysis, subgroup sensitivity restricted cubic spline examine relationship SII Results Our revealed that exhibits a quantitative association MetS [odds ratio (OR) = 1.56; 95% confidence interval (CI): 1.37-1.79; P &lt; .001]. Elevated is an independent risk factor for 5 components Different groups alcohol consumption status could modify was statistically significant in 18 65 group but not elderly (OR 1.08; CI, .95-1.23; .248). Multiple imputation confirmed robustness our results. Moreover, inverted U-shaped curve. Conclusion highlights predictive significance forecasting incidence young middle-aged populations. The differences mechanisms various necessitate further exploration.

Language: Английский

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Identifying Semaphorin 3C as a Biomarker for Sarcopenia and Coronary Artery Disease Via Bioinformatics and Machine Learning

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 131, P. 105762 - 105762

Published: Jan. 15, 2025

Language: Английский

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Sarcopenia in Chronic Kidney Disease: A Narrative Review from Pathophysiology to Therapeutic Approaches

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 352 - 352

Published: Feb. 4, 2025

Chronic kidney disease (CKD) is a progressive condition linked to sarcopenia, syndrome characterized by loss of skeletal muscle mass and strength, affecting quarter CKD patients globally. Sarcopenia has multiple paths through which it can worsen morbidity mortality as well decrease the quality life in CKD, including systemic inflammation, hormonal imbalances, metabolic changes, dysbiosis gut microbiota. There regional variation criteria set for diagnosis, with two main groups being European Working Group on Older People Asian Sarcopenia. Management regimes such nutritional optimization, vitamin D, exercise, correction acidosis, modulation microbiota constitute effective intervention strategies. Emerging therapeutic options include anabolic agents, myostatin inhibitors, anti-inflammatory treatment options. Future advances genomics, proteomics, personalized medicine will open up new avenues addressing complex pathophysiology sarcopenia. Hence, comprehensive multidisciplinary approach focused specific needs each patient be vital reducing effects sarcopenia improving situation people CKD.

Language: Английский

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The impact of bariatric surgery and exercise on systemic immune inflammation index in patients with sarcopenia obesity

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 12, 2025

Abstract The role of obesity in contributing to inflammation is an influential factor the progression obesity-associated medical issues. Metabolic and bariatric surgery has been proven as effective obtaining weight loss associated conditions remission. Systemic Immune Inflammation Index (SII) was developed offer more comprehensive data on presented a prognostic indicator regarding many adverse conditions. present study aimed investigate association between SII patients with sarcopenic evaluate eventual impact exercise SII. All participants were obesity, underwent - RYGP randomized participate structured physical or control group. assessments performed following standardized procedures, evaluated during routine clinic follow-up at preoperative 20-weeks postoperative after program. At baseline, before surgery, both groups had similar anthropometrics, body composition, muscle strength variables percentage comorbidities. also groups. To better understand different variables, Pearson correlation test baseline using There inverse BMC, handgrip ASMM which maintained 5 months surgery. end study, combined results two showed that weight, BMI, % fat, mass strength, 30s sit-to-stand bone mineral density all decreased significantly expected, along significantly. intervention group higher ASMM, Sit-to-stand 400-m walk when compared However, no difference ( p > 0.05). current research show positive negative function. responded very favorably without exercise, clear decrease its score. Higher lower function, this may be reflex compromise causes health, case, increasing systemic decreasing management surgical still not clear. After program function (without exercise). there differences score groups, interpreted lack effect per se short-term inflammatory condition obesity.

Language: Английский

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Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: March 10, 2025

Background This research delved into the association between systemic immune-inflammatory index (SII) and both all-cause cancer-specific mortality among individuals aged 60 years above in United States during period from 1999 to 2018, with follow-up extending until 31 December 2019. The data utilized was sourced 4295 population-based participants National Health Nutrition Examination Survey (NHANES). Methods To analyze relationship SII mortality, study employed Cox proportional-risk models, restricted cubic spline curves, survival subgroup analyses. Results average age of 70.7 (±7.6) years, median duration 131.7 (±59.8) months, rate stood at 50.5%. Findings regression model indicated that, after adjusting for covariates, significantly linearly related (hazard ratio HR = 1.31, 95% confidence interval CI 1.15–1.48). Moreover, cancer exhibited a U-shaped pattern. curves suggested that higher associated an augmented risk mortality. Conclusion There is significant levels increased US population older.

Language: Английский

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Appendicular Skeletal Muscle Mass (ASMM) and Fat-Free Mass (FFM) DXA–BIA Estimations for the Early Identification of Sarcopenia/Low Muscle Mass in Middle-Aged Women

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3897 - 3897

Published: Nov. 15, 2024

Sarcopenia involves the loss of muscle mass along with a decrease in strength and physical performance. The aim this paper was to compare already published BIA equations for estimation Appendicular Skeletal Muscle Mass (ASMM) Fat-Free (FFM) dual X-ray densitometer DXA estimations order determine whether Bioelectrical Impedance Analysis (BIA) could be feasible application on general population detection low sarcopenia.

Language: Английский

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Exploring the association between pro-inflammatory mediators and sarcopenia in cancer patients through different diagnostic tools: a narrative review

Annals of Translational Medicine, Journal Year: 2024, Volume and Issue: 12(6), P. 114 - 114

Published: Dec. 1, 2024

Sarcopenia, characterized by the progressive loss of skeletal muscle mass (MM) and function, is a common debilitating condition in cancer patients, significantly impacting their quality life, treatment outcomes, overall survival. The pathophysiology sarcopenia multifactorial, involving metabolic, hormonal, inflammatory changes. Recent research highlights role chronic inflammation development progression sarcopenia, with pro-inflammatory cytokines being key mediators catabolism. primary objective this study was to assess identifying among patients. As secondary objective, we aim investigate whether methods used for assessing both imaging functional, align established guidelines. A search Web Science conducted English-language articles published since 2005, following terms: "Cancer" AND "Sarcopenia" "Pro-inflammatory cytokine*" OR "Interleukin*". Inclusion criteria included peer-reviewed controlled trials, observational studies, case reports, series. To avoid redundancy, results which were systematic reviews, narrative or scoping reviews excluded from review. analysis 10 selected papers, including 1,138 revealed lack assessment strength (MS) functional performance most studies on contradicting comprehensive nature that includes MM, MS, functionality. There no standardization identification. Future should focus establishing cutoff points are linked sarcopenia. Given complexity different cancers, new projects cytokine expression depends tumor type. Moreover, considering majority population comprised elderly individuals it crucial discern extent findings influenced age versus cancer-related factors.

Language: Английский

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