Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

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AlphaFold-Based AI Docking Reveals AMPK/SIRT1-TFEB Pathway Modulation by Traditional Chinese Medicine in Metabolic-Associated Fatty Liver Disease

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107617 - 107617

Published: Jan. 1, 2025

Language: Английский

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The efficacy of traditional Chinese medicine sequential therapy in non-alcoholic fatty liver disease

Pakistan Journal of Medical Sciences, Journal Year: 2025, Volume and Issue: 41(2), P. 512 - 518

Published: Jan. 23, 2025

Objective: Sequential therapy in traditional Chinese medicine (TCM) refers to a combination of internal and external treatment methods certain order based on syndrome differentiation therapy. The aim this study was evaluate the efficacy TCM sequential that is given basis conventional management patients with non-alcoholic fatty liver disease (NAFLD). Methods: Medical records one hundred NAFLD who received at Zhejiang Provincial Tongde Hospital between February 2023 April 2024 were retrospectively analyzed. Of them, 48 routine intervention (Control group), 52 additionally treated by (TCM group). levels blood lipid indicators, function efficacy, quality life (QOL) scores compared two groups before after intervention. Results: After intervention, indicators both significantly improved preintervention considerably better Control group (P<0.05). overall higher (94.23%) (79.17%) QOL increased than Conclusions: For patients, adopting addition strategies can effectively regulate patients’ levels, restore function, improve effectiveness, life. doi: https://doi.org/10.12669/pjms.41.2.11352 How cite this: Zhang L, Qian Y, Wu H, Xu H. disease. Pak J Med Sci. 2025;41(2):512-518. This an Open Access article distributed under terms Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, reproduction any medium, provided original work properly cited.

Language: Английский

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Global research trends in Chinese medicine for the treatment of non-alcoholic fatty liver disease (NAFLD): a bibliometric study

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100585 - 100585

Published: Feb. 1, 2025

Language: Английский

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Targeting Metabolic Diseases with Celastrol: A Comprehensive Review of Anti-Inflammatory Mechanisms and Therapeutic Potential

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119560 - 119560

Published: Feb. 1, 2025

Language: Английский

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Rhizoma Atractylodis Macrocephalae reduces HFD-induced NAFLD in mice through activated AMPK mediated inhibition of fatty acid synthesis

Liver Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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The Liver in View of Acupuncture

Current Hepatology Reports, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 24, 2025

Language: Английский

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Interplay of the pathophysiological mechanisms of Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, and Inflammation: A growing threat to public health

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100613 - 100613

Published: April 1, 2025

Language: Английский

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Deciphering the mechanism of Chaihu Shugan San in the treatment of nonalcoholic steatohepatitis using network pharmacology and molecular docking

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Objectives In China, there is a long history and rich clinical experience in treating nonalcoholic steatohepatitis (NASH) with traditional Chinese herbal medicines, including Chai Hu Shu Gan San. This study aims to investigate the potential regulatory effects of Chaihu Shugan San (CSS) on liver lipid metabolism inflammatory damage mice experimental induced by choline-deficient high-fat diet (CDHFD). Utilizing network pharmacology, we systematically explore mechanisms action therapeutic CSS against NASH. Methods Potential targets for NASH were identified using online databases. Functional enrichment protein–protein interaction analyses conducted identify hub-targeted genes elucidate underlying molecular mechanisms. The affinities active compounds evaluated docking. Finally, validated through real-time polymerase chain reaction, western blotting, immunofluorescence mice, both without treatment. Key findings reduces serum ALT AST levels mice(P &lt; 0.05) ameliorates ballooning degeneration livers thereby lowering NAS score(P 0.05). Including naringenin, high-performance liquid chromatography/mass spectrometrys 12 chromatographic peaks. Based pharmacology analysis, contains total 103 877 target genes. Transferase activity represents mechanism intervention transcriptional protein expression SIRT1 gene are significantly increased (P Conclusions Naringenin probable compound hub which involved

Language: Английский

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Integrated Thermal Proteome Profiling and Affinity Ultrafiltration Mass Spectrometry (iTPAUMS): A Novel Paradigm for Elucidating the Mechanism of Action of Natural Products

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Natural products (NPs) are foundational to drug discovery, offering a rich repertoire of molecular diversity with multifaceted modes action against broad array targets. Despite their potential, deconvoluting the intricate mechanism (MoA) NPs, characterized by multicomponent, multitarget, and multilevel interactions, remains formidable challenge. Here, we introduce an innovative pipeline called integrated thermal proteome profiling affinity ultrafiltration mass spectrometry (iTPAUMS). This approach combines high-throughput capacity (TPP) specificity (AUMS), creating powerful toolkit for elucidating complex MoAs NPs. Significantly, our investigation represents pioneering application TPP delineate target group NPs mixtures overcome long-standing obstacle mapping specific component-target interactions through AUMS. Our findings demonstrate utility iTPAUMS in constructing comprehensive atlas, providing robust analytical foundation unraveling pharmacological landscapes advancing discovery.

Language: Английский

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