Advanced technologies for the study of neuronal cross-organ regulation: a narrative review DOI

Ran Lin,

Yuxi Guo,

Weiting Jiang

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 166 - 176

Published: Nov. 27, 2024

The nervous system plays an integral role in the homeostasis of living organisms through regulation multiple organ systems. Research has highlighted extensive regulating function, including key aspects such as metabolic processes, respiratory, cardiovascular, and immune responses. These findings are inseparable from development new technologies viral tracing, optogenetics, whole-tissue imaging, neural activity recording. As technology continues to advance, our understanding regulatory other organs expanded more complex cognitive emotional control systems, cerebral cortex subcortical areas. Recent studies have also shown bidirectional cross-organ mechanisms between gut microbiota brain. In addition, body–brain axis monitors inflammatory responses ensure a balance proinflammatory anti-inflammatory This review delves into intricate functions they pertain communication, emphasizing broader implications that extend beyond mere regulation. It employs cutting-edge clearing, vivo neuronal recording dissect influence on various organs, but not limited heart, liver, spleen. advanced methodologies substantially broadened comprehension fundamental operations within diverse physiological revealing networks orchestrate organ-specific functions. Our highlights significant potential pave way for therapeutic strategies aimed at addressing wide array conditions impact health.

Language: Английский

Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway DOI Creative Commons

Zhengguo Qiu,

Jianbing Ma, Xiaqing Zhang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111200 - 111200

Published: Jan. 1, 2025

Electroacupuncture (EA) and trigonelline (TG) have been reported to be beneficial in alleviating cerebral ischemia/reperfusion injury (CIRI). However, the synergistic effects of EA TG CIRI underlying mechanism not demonstrated. Rats were subjected middle artery occlusion (MCAO) surgery reperfusion (MCAO/R) establish a model. Neurological deficit score was evaluated using Garcia's scale. Cerebral infarction rats determined TTC staining. Brain tissue morphology assessed by HE The expression various proteins measured IF assay western blot. or treatment could effectively ameliorate neurological disorders, attenuate reduce neuronal damage brain rats. In addition, suppressed autophagy pyroptosis More importantly, intervention observed ameliorating suppressing pyroptosis, while Rapa, an inducer autophagy, strengthened these MCAO/R-induced Furthermore. Rapa reversed combination with TG-mediated improvement suppression Notably, PI3K/AKT/mTOR pathway inactivated combined enhanced activation pathway. LY294002, inhibitor pathway, stimulated pyroptosis. which dependent on inhibition through signaling

Language: Английский

Citations

1
Electroacupuncture Preconditioning Attenuates Myocardial Ischemia-Reperfusion Injury in Rats Partially Through Nrf2-Mediated Reduction of Oxidative Stress and Pyroptosis DOI
Xuefeng Xia,

Ding Yaping,

Zhou Chunmei

et al.

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 20, 2025

Oxidative stress and pyroptosis have been established as key contributors to myocardial ischemia-reperfusion injury (MIRI). While previous studies reported that electroacupuncture (EA) preconditioning exerted cardioprotective effects, the underlying mechanisms remain elusive. Thus, this study aimed investigate effects of EA on oxidative in MIRI rats, explore role nuclear factor E2-associated 2 (Nrf2) throughout process. A model was constructed by ligating left anterior descending coronary artery for 30 min, followed 4 h reperfusion rats. Prior modeling, rats were subjected at Neiguan Point three days. Furthermore, ML385, a Nrf2 inhibitor, administered order examine regulating following preconditioning. The results revealed improved ventricular function after reduced both infarction area cTnT levels. Meanwhile, alleviated MIRI-induced pyroptosis, evidenced downregulation ROS, MDA, NF-[Formula: see text]B p65, caspase-1, IL-1[Formula: text], GSDMD-N, upregulation SOD HO-1. Mechanistically, up-regulated enhanced expression Nrf2. However, its ability attenuate suppressed inhibition Taken together, our indicated attenuated mitigating with playing vital protective mechanism.

Language: Английский

Citations

0
Key targets of signal transduction neural mechanisms in acupuncture treatment of cardiovascular diseases: hypothalamus and autonomic nervous system DOI Creative Commons
Xiang Zhou, Jie Zhou, Fan Zhang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38197 - e38197

Published: Sept. 20, 2024

Language: Английский

Citations

1
Neurophysiological Basis of Electroacupuncture Stimulation in the Treatment of Cardiovascular‐Related Diseases: Vagal Interoceptive Loops DOI Creative Commons
Yun Liu, Tiancheng Xu, Zhi Yu

et al.

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(10)

Published: Sept. 30, 2024

ABSTRACT Purpose The vagal sensory nerve (VSN) is an essential interoceptive pathway that connected to every level of the body. Its intricate genetic coding provides sustenance for physiological processes, including controlling blood pressure and respiration. Electroacupuncture (EA) a proven surface stimulation therapy can regulate activity, which effectively prevent cardiovascular diseases. A growing number studies have concentrated on mapping VSN codes, but little known, background how EA influences has not been fully explored. Method Here, we incorporate hypothesized interaction among targets, VSNs, heart. This offers suggestions using versatile focused strategy modify awareness enhance conditions. We first clarified major role in control cardiac activity. Additionally, multidimensional pattern revealing targeted multimodal functional basis synchronization system. Finding propose VSNs employed activate loop reduce risk disease.

Language: Английский

Citations

0
Overview of mechanism of electroacupuncture pretreatment for prevention and treatment of cardiovascular and cerebrovascular diseases DOI Creative Commons

Jiaming Zeng,

Jiaojiao Cao, Haitao Yang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(10)

Published: Oct. 1, 2024

Cardio-cerebrovascular disease (CCVD) is a serious threat to huma strategy prevent the occurrence and development of by giving electroacupuncture intervention before occurs. EAP has been shown in many preclinical studies relieve ischemic symptoms improve damage from ischemia-reperfusion, with no comprehensive review its mechanisms cardiovascular yet. In this paper, we first systematically discussed meridian acupoint selection law for CCVD focused on progress mechanism action prevention treatment CCVD. As result, studies, AMI MCAO models are commonly used simulate injury CCVD, while MIRI CI/RI reperfusion caused blood flow recovery after focal tissue ischemia. According matching rules PC6 pericardial most diseases, GV20 Du cerebrovascular diseases. terms parameters, generally lasts 30 min, acupuncture depths mostly between 1.5 5 mm, stimulation intensities at 1 mA, frequencies being low frequencies. molecular mechanisms, key pathways preventing treating diseases partially similar. can play protective role promoting autophagy, regulating Ca

Language: Английский

Citations

0
Advanced technologies for the study of neuronal cross-organ regulation: a narrative review DOI

Ran Lin,

Yuxi Guo,

Weiting Jiang

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 166 - 176

Published: Nov. 27, 2024

The nervous system plays an integral role in the homeostasis of living organisms through regulation multiple organ systems. Research has highlighted extensive regulating function, including key aspects such as metabolic processes, respiratory, cardiovascular, and immune responses. These findings are inseparable from development new technologies viral tracing, optogenetics, whole-tissue imaging, neural activity recording. As technology continues to advance, our understanding regulatory other organs expanded more complex cognitive emotional control systems, cerebral cortex subcortical areas. Recent studies have also shown bidirectional cross-organ mechanisms between gut microbiota brain. In addition, body–brain axis monitors inflammatory responses ensure a balance proinflammatory anti-inflammatory This review delves into intricate functions they pertain communication, emphasizing broader implications that extend beyond mere regulation. It employs cutting-edge clearing, vivo neuronal recording dissect influence on various organs, but not limited heart, liver, spleen. advanced methodologies substantially broadened comprehension fundamental operations within diverse physiological revealing networks orchestrate organ-specific functions. Our highlights significant potential pave way for therapeutic strategies aimed at addressing wide array conditions impact health.

Language: Английский

Citations

0