Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 185 - 200

Published: Jan. 1, 2025

Abstract: Cerebral ischemia-reperfusion injury (CIRI) is clinically characterized by high rates of morbidity, disability, mortality, and recurrence as well economic burden. The clinical manifestations CIRI are often accompanied gastrointestinal symptoms such intestinal bacterial dysbiosis bleeding. Gut microbiota plays an important role in the pathogenesis CIRI, its potential biological effects have received extensive attention. gut not only affects barrier function but also regulates immunity host homeostasis. Traditional Chinese medicine (TCM), a multi-component multi-targeted drug, has shown remarkable few adverse reactions prevention treatment CIRI. Notably, effect TCM on regulating maintaining homeostasis gradually become hot topic. This review summarizes functional development progression therapeutic improving dysbiosis, affecting metabolism, immunity. active ingredients used for relevant studies were saponins, triterpenoids, phenolics, alkaloids. In addition, to treat briefly discussed. established significance prospects TCM-based treatments provided necessary theoretical support further resources Keywords: cerebral injury, ischemic stroke, gut-brain axis, microbiota, traditional

Language: Английский

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ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 3925 - 3947

Published: May 1, 2025

This study investigates the effect of Shenqi Shenkang granule (SQSKG) on chronic kidney disease (CKD), focusing regulating PI3K/AKT/mTOR pathway, autophagy, and mitochondrial homeostasis. The compounds targets SQSKG CKD were identified by network pharmacology validated molecular docking. LC-MS/MS was used to verify screened pharmacology. In vitro experiments based HK-2 cells assess its impact cell migration, viability, oxidative stress, key proteins fibrosis. Mitochondrial function autophagic flux evaluated via JC-1, Mito-Tracker, Ad-mCherry-GFP-LC3B assays. vivo, an adenine-induced rat model analyze renal function, fibrosis, autophagy through serum/urine tests, histology, immunofluorescence. Network 49 149 associated with SQSKG's therapeutic effects CKD, highlighting critical such as AKT1, MAPK1, EGFR, HSP90AA, IGF1R. primary mechanism involves PI3K/AKT pathway. demonstrated that significantly enhanced colony formation, viability in AGEs-treated cells, exhibited robust antioxidant properties increasing SOD levels reducing MDA ROS production. effectively inhibited phosphorylation PI3K, AKT, mTOR, reduced TGF-β fluorescence intensity tissue. Autophagic analysis showed increased activity p62 accumulation. Additionally, JC-1 Mito-Tracker Green assays improved membrane potential morphology. alleviated fibrosis a dose-dependent manner, reversing marker overexpression (Col-I, α-SMA, TGF-β) activating autophagy. Our findings provide novel insights into management, ability modulate flux, restoring integrity, thereby offering promising complementary or alternative treatment option for patients CKD.

Language: Английский

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Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156623 - 156623

Published: March 10, 2025

Language: Английский

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Exploring the mechanism of Taohong Siwu Decoction in treating ischemic stroke injury via the circDnajc1/miR-27a-5p/C1qc signaling axis

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156305 - 156305

Published: Nov. 28, 2024

Language: Английский

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