From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 7, 2025

In recent 10 years, ferroptosis has become a hot research direction in the scientific community as new way of cell death. Iron toxicity accumulation and lipotoxicity are unique features. Several studies have found that is involved regulation hepatic microenvironment various metabolisms, thereby mediating progression related liver diseases. For example, NRF2 FSP1, important regulatory proteins ferroptosis, development tumors failure. this manuscript, we present mechanisms concern with addition, summarize clinical advances targeted therapy for We expect manuscript can provide perspective treatment

Language: Английский

Flotillin- 1 ameliorates experimental diabetic retinopathy by inhibiting ferroptosis in blood-retinal barrier

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский