A detection model for cognitive dysfunction based on volatile organic compounds from a large Chinese community cohort DOI Creative Commons
Bin Jiao, Sizhe Zhang,

Yuzhang Bei

et al.

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 19(11), P. 4852 - 4862

Published: April 9, 2023

Abstract Introduction We explored whether volatile organic compound (VOC) detection can serve as a screening tool to distinguish cognitive dysfunction (CD) from cognitively normal (CN) individuals. Methods The function of 1467 participants was assessed and their VOCs were detected. Six machine learning algorithms conducted the performance determined. plasma neurofilament light chain (NfL) measured. Results Distinguished VOC patterns existed between CD CN groups. model showed good accuracy with an area under receiver‐operating characteristic curve (AUC) 0.876. In addition, we found that 10 ions significant differences individuals ( p < 0.05); three significantly related NfL 0.005). Moreover, combination best discriminating power (AUC = 0.877). Discussion Detection exhaled breath samples has potential provide novel solution for dilemma screening.

Language: Английский

Quinoline–sulfonamides as a multi-targeting neurotherapeutic for cognitive decline:in vitro,in silicostudies and ADME evaluation of monoamine oxidases and cholinesterases inhibitors DOI Creative Commons
Saquib Jalil, Zahid Hussain,

Syed Mobashir Ali Abid

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(13), P. 8905 - 8920

Published: Jan. 1, 2024

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder with multiple enzymes involved.

Language: Английский

Citations

9
The Probiotic Lactobacillus reuteri Preferentially Synthesizes Kynurenic Acid from Kynurenine DOI Open Access
Robert Schwarcz,

A Y Foo,

Korrapati V. Sathyasaikumar

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3679 - 3679

Published: March 26, 2024

The gut–brain axis is increasingly understood to play a role in neuropsychiatric disorders. probiotic bacterium Lactobacillus (L.) reuteri and products of tryptophan degradation, specifically the neuroactive kynurenine pathway (KP) metabolite kynurenic acid (KYNA), have received special attention this context. We, therefore, assessed relevant features KP metabolism, namely, cellular uptake pivotal its conversion primary KYNA, 3-hydroxykynurenine anthranilic L. by incubating bacteria Hank’s Balanced Salt solution vitro. Kynurenine readily entered bacterial cells was preferentially converted which promptly released into extracellular milieu. De novo production KYNA increased linearly with increasing concentrations (up 1 mM) (107 109 CFU/mL) incubation time (1–3 h). neosynthesis blocked two selective inhibitors mammalian aminotransferase II (PF-048559989 BFF-122). In contrast mammals, however, not influenced other substrates large neutral amino transporter, affected presumed competitive enzyme (glutamine α-aminoadipate). Taken together, these results reveal substantive qualitative differences between metabolism.

Language: Английский

Citations

9
Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy DOI Creative Commons
Rebecca F. Slykerman, Naomi Davies, Klára Vlčková

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of gut microbiome as a tractable therapeutic target for gastrointestinal, mental brain health. Current research is still marked by many open questions that undermine widespread application humans. For example, lack mechanistic understanding probiotic effects means it remains unclear why even apparently closely related strains exhibit different in vivo. live microbial psychobiotics, consensus on their adjunct treatments conventional neuromodulators, use unmedicated populations or at‐risk cohorts with sub‐clinical symptomatology warranted. This missing information both sides equation when treating central nervous system (CNS) conditions makes psychobiotic challenging, especially compared other pharmaceutical functional food approaches. Expediting transition from positive preclinical data proven benefits humans includes interpreting promises pitfalls animal behavioural assays, well navigating mechanism‐informed decision making select right microbe(s) job. In this review, we consider how these decisions can be supported light accrued range clinical studies across healthy, pathological study populations, where specific have been evaluated context gastrointestinal physiology, function behaviour. Examples successful, partial unsuccessful translation bench bedside are considered. We also discuss developments silico analyses enhanced our moved towards pinpointing host–microbe interactions most important optimal gut–brain function. Combining assays vitro ex vivo domains incorporating model organisms prime discovery pipelines promising rationally selected candidates.

Language: Английский

Citations

1
The role of the intestinal microbiome in cognitive decline in patients with kidney disease DOI Creative Commons
Carsten A. Wagner, Isabelle Frey‐Wagner, Alberto Ortíz

et al.

Nephrology Dialysis Transplantation, Journal Year: 2025, Volume and Issue: 40(Supplement_2), P. ii4 - ii17

Published: March 1, 2025

ABSTRACT Cognitive decline is frequently seen in patients with chronic kidney disease (CKD). The causes of cognitive these are likely to be multifactorial, including vascular disease, uraemic toxins, blood–brain barrier leakage, and metabolic endocrine changes. Gut dysbiosis common CKD contributes the increase toxins. However, gut microbiome modulates local systemic levels several metabolites such as short-chain fatty acids or derivatives tryptophan metabolism, neurotransmitters, endocannabinoid-like mediators, bile acids, hormones glucagon-like peptide 1 (GLP1) cholecystokinin (CCK). These factors can affect function, immunity, autonomic nervous system activity various aspects brain function. Key areas include integrity, nerve myelination survival/proliferation, appetite, metabolism thermoregulation, mood, anxiety depression, stress inflammation. Alterations composition microbiota production biologically active well documented favoured by low-fiber diets, elevated urea levels, sedentary lifestyles, slow stool transit times polypharmacy. In turn, modulate function processes, discussed this review. Thus, may contribute alterations cognition a target for therapeutic interventions using diet, prebiotics probiotics.

Language: Английский

Citations

1
A detection model for cognitive dysfunction based on volatile organic compounds from a large Chinese community cohort DOI Creative Commons
Bin Jiao, Sizhe Zhang,

Yuzhang Bei

et al.

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 19(11), P. 4852 - 4862

Published: April 9, 2023

Abstract Introduction We explored whether volatile organic compound (VOC) detection can serve as a screening tool to distinguish cognitive dysfunction (CD) from cognitively normal (CN) individuals. Methods The function of 1467 participants was assessed and their VOCs were detected. Six machine learning algorithms conducted the performance determined. plasma neurofilament light chain (NfL) measured. Results Distinguished VOC patterns existed between CD CN groups. model showed good accuracy with an area under receiver‐operating characteristic curve (AUC) 0.876. In addition, we found that 10 ions significant differences individuals ( p < 0.05); three significantly related NfL 0.005). Moreover, combination best discriminating power (AUC = 0.877). Discussion Detection exhaled breath samples has potential provide novel solution for dilemma screening.

Language: Английский

Citations

17