Exploring the protective association between COVID-19 infection and laryngeal cancer: insights from a Mendelian randomization study DOI Creative Commons
Heng Wang, Ning Fang,

Prithweeraj Mozumder

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 10, 2024

Introduction Viral infections have been implicated as a risk factor for laryngeal cancer. Given the possible effects of Corona virus disease 2019 (COVID-19) on tissue, we investigated causal link between COVID-19 and cancer using two-sample Mendelian randomization (MR) approach. Methods We utilized genetic data from 5th Genome-wide association studies (GWAS) edition Host Genetics Initiative (published January 18, 2021) large-scale GWAS comprising 180 cases 218,612 controls European ancestry. applied inverse variance weighting, MR Egger, weighted median methods to infer causality. performed sensitivity analysis “leave-one-out” method verify robustness. Results found no evidence gene-predicted [Odds ratio (OR)=0.24 (95% Confidence intervals (CI), 0.05–1.26), P=0.09]. However, observed significant associations hospitalization [OR=0.51 CI, 0.28–0.95), P=0.03] severe patients [OR=0.62 0.43–0.90), P=0.01] Notably, study detected important variants, such rs13050728, that modulate expression interferon alpha receptor 2 (IFNAR2), indicating roles immune response pathways in both Discussion This reveals potential interaction severity, factors, cancer, underscoring importance investigating mechanisms conditions. These findings contribute understanding complex interactions may guide future research role response, particularly involving IFNAR2.

Language: Английский

Improving CD3 bispecific antibody therapy in solid tumors using combination strategies DOI Creative Commons

Katy A. Lloyd,

Jim Middelburg, Vitalijs Ovcinnikovs

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 10, 2025

CD3 bispecific antibodies (bsAbs) are emerging as an important treatment option in the arsenal of oncologists. There numerous FDA-approved bsAbs for both hematological and solid tumors. Despite these recent advances, success cancer has been hampered by hurdles like limited intratumoral T cell numbers, immunosuppressive tumor microenvironments (TME), poor memory T-cell induction. Furthermore, surface antigen selection optimal therapeutic window acceptable collateral damage to normal tissues is challenging. In this review, we discuss research investigating combination approaches aimed at improving bsAb efficacy cancer.

Language: Английский

Citations

0
Exploring the protective association between COVID-19 infection and laryngeal cancer: insights from a Mendelian randomization study DOI Creative Commons
Heng Wang, Ning Fang,

Prithweeraj Mozumder

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 10, 2024

Introduction Viral infections have been implicated as a risk factor for laryngeal cancer. Given the possible effects of Corona virus disease 2019 (COVID-19) on tissue, we investigated causal link between COVID-19 and cancer using two-sample Mendelian randomization (MR) approach. Methods We utilized genetic data from 5th Genome-wide association studies (GWAS) edition Host Genetics Initiative (published January 18, 2021) large-scale GWAS comprising 180 cases 218,612 controls European ancestry. applied inverse variance weighting, MR Egger, weighted median methods to infer causality. performed sensitivity analysis “leave-one-out” method verify robustness. Results found no evidence gene-predicted [Odds ratio (OR)=0.24 (95% Confidence intervals (CI), 0.05–1.26), P=0.09]. However, observed significant associations hospitalization [OR=0.51 CI, 0.28–0.95), P=0.03] severe patients [OR=0.62 0.43–0.90), P=0.01] Notably, study detected important variants, such rs13050728, that modulate expression interferon alpha receptor 2 (IFNAR2), indicating roles immune response pathways in both Discussion This reveals potential interaction severity, factors, cancer, underscoring importance investigating mechanisms conditions. These findings contribute understanding complex interactions may guide future research role response, particularly involving IFNAR2.

Language: Английский

Citations

0