Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb DOI Creative Commons
Jenelle L. Wallace,

Julia Lord,

Lasse Dissing‐Olesen

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: March 6, 2020

Microglia play key roles in regulating synapse development and refinement the developing brain, but it is unknown whether they are similarly involved during adult neurogenesis. By transiently depleting microglia from healthy mouse we show that necessary for normal functional of adult-born granule cells (abGCs) olfactory bulb. Microglial depletion reduces odor responses developing, not preexisting GCs vivo both awake anesthetized mice. preferentially target their motile processes to interact with mushroom spines on abGCs, when absent, abGCs develop smaller receive weaker excitatory synaptic inputs. These results suggest promote synapses onto which may impact function these circuit.

Language: Английский

Microglia states and nomenclature: A field at its crossroads DOI Creative Commons
Rosa Chiara Paolicelli, Amanda Sierra, Beth Stevens

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(21), P. 3458 - 3483

Published: Nov. 1, 2022

Language: Английский

Citations

1073
Negative feedback control of neuronal activity by microglia DOI
Ana Badimon, Hayley J. Strasburger, Pinar Ayata

et al.

Nature, Journal Year: 2020, Volume and Issue: 586(7829), P. 417 - 423

Published: Sept. 30, 2020

Language: Английский

Citations

742
Microglia regulation of synaptic plasticity and learning and memory DOI Creative Commons
Miou Zhou,

Jessica Cornell,

Shelbi Salinas

et al.

Neural Regeneration Research, Journal Year: 2021, Volume and Issue: 17(4), P. 705 - 705

Published: Aug. 29, 2021

Microglia are the resident macrophages of central nervous system. possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state constantly monitor their microenvironment survey neuronal synaptic activity. Through C1q, C3 CR3 "Eat Me" CD47 SIRPα "Don't Eat complement pathways, as well other pathways such CX3CR1 signaling, regulate pruning, process crucial for promotion synapse formation regulation activity plasticity. By mediating play an important role experience-dependent plasticity barrel cortex visual after whisker removal or monocular deprivation, also learning memory, including modulation memory strength, forgetfulness, quality. As response to brain injury, infection neuroinflammation, become activated increase number. Activated change amoeboid shape, migrate sites inflammation secrete proteins cytokines, chemokines reactive oxygen species. These molecules released by can lead deficits associated with aging, Alzheimer's disease, traumatic HIV-associated neurocognitive disorder, neurological mental disorders autism, depression post-traumatic stress disorder. With focus on recently published literature, here we reviewed studies investigating how modulate disease-related deficits. summarizing function these processes, aim provide overview discuss possibility manipulation therapeutic ameliorate cognitive disorders.

Language: Английский

Citations

309
Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS DOI
Travis E. Faust, Georgia Gunner, Dorothy P. Schafer

et al.

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(11), P. 657 - 673

Published: Sept. 20, 2021

Language: Английский

Citations

266
Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions DOI Creative Commons
Csaba Cserép, Balázs Pósfai, Ádám Dénes

et al.

Neuron, Journal Year: 2020, Volume and Issue: 109(2), P. 222 - 240

Published: Dec. 2, 2020

Language: Английский

Citations

180
How microglia sense and regulate neuronal activity DOI
Anthony D. Umpierre, Long‐Jun Wu

Glia, Journal Year: 2020, Volume and Issue: 69(7), P. 1637 - 1653

Published: Dec. 28, 2020

Microglia are innate immune cells of the central nervous system that sense extracellular cues. Brain injuries, inflammation, and pathology evoke dynamic structural responses in microglia, altering their morphology motility. The motility microglia is hypothesized to be a critical first step sensing local alterations engaging pattern-specific responses. Alongside pathological responses, also regulate neuronal activity. In this review, we consider molecules, receptors, mechanisms allow activity changes under both hypoactivity hyperactivity. We highlight emerging vivo evidence activity, ranging from physiological pathophysiological conditions. addition, discuss role calcium signaling microglial environment. function monitoring influencing may for brain homeostasis circuit modification health disease.

Language: Английский

Citations

152
The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation DOI Creative Commons

Ningcen Li,

Yi Guo, Yinan Gong

et al.

Journal of Inflammation Research, Journal Year: 2021, Volume and Issue: Volume 14, P. 7191 - 7224

Published: Dec. 1, 2021

Inflammation plays a significant role in the occurrence and development of multiple diseases. This study comprehensively reviews presents literature from last five years, showing that acupuncture indeed exerts strong anti-inflammatory effects biological systems, namely, immune, digestive, respiratory, nervous, locomotory, circulatory, endocrine, genitourinary systems. It is well known localized acupuncture-mediated involve regulation populations functions immune cells, including macrophages, granulocytes, mast T cells. In stimulation, macrophages transform M1 to M2 phenotype negative TLR4 regulator PPARγ activated inhibit intracellular TLR/MyD88 NOD signaling pathways. The downstream IκBα/NF-κB P38 MAPK pathways are subsequently inhibited by acupuncture, followed suppressed production inflammasome proinflammatory mediators. Acupuncture also modulates balance helper cell populations. Furthermore, it inhibits oxidative stress enhancing SOD activity via Nrf2/HO-1 pathway eliminates generation oxygen free radicals, thereby preventing inflammatory infiltration. on different systems specific individual organ microenvironments. As part its action, deforms connective tissue upregulates secretion various molecules acupoints, further activating NF-κB, MAPK, ERK fibroblasts, keratinocytes, monocytes/macrophages. somatic afferents present acupuncture-activated acupoints convey sensory signals spinal cord, brainstem, hypothalamic neurons. Upon information integration brain, stimulates neuro-immune pathways, cholinergic anti-inflammatory, vagus-adrenal medulla-dopamine, sympathetic as hypothalamus-pituitary-adrenal axis, ultimately acting cells release crucial neurotransmitters hormones. review provides scientific reliable basis viewpoints for clinical application conditions.

Language: Английский

Citations

114
Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials DOI Creative Commons
Jifei Miao,

Haixia Ma,

Yang Yang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: June 15, 2023

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by protein aggregation in the brain. Recent studies have revealed critical role of microglia AD pathogenesis. This review provides comprehensive summary current understanding microglial involvement AD, focusing on genetic determinants, phenotypic state, phagocytic capacity, neuroinflammatory response, and impact synaptic plasticity neuronal regulation. Furthermore, recent developments drug discovery targeting are reviewed, highlighting potential avenues for therapeutic intervention. emphasizes essential insights into treatments.

Language: Английский

Citations

95
Tuning neural circuits and behaviors by microglia in the adult brain DOI Open Access
Shunyi Zhao, Anthony D. Umpierre, Long‐Jun Wu

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(3), P. 181 - 194

Published: Jan. 21, 2024

Language: Английский

Citations

42
P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape DOI Creative Commons
Ukpong B. Eyo, Mingshu Mo, Min‐Hee Yi

et al.

Cell Reports, Journal Year: 2018, Volume and Issue: 23(4), P. 959 - 966

Published: April 1, 2018

Microglia are an exquisitely tiled and self-contained population in the CNS that do not receive contributions from circulating monocytes periphery. While microglia long-lived cells, extent to which their cell bodies fixed molecular mechanisms by microglial landscape is regulated have been determined. Using chronic vivo two-photon imaging follow young adult mice, we document a daily rearrangement of landscape. Furthermore, show can be modulated severe seizures, acute injury, sensory deprivation. Finally, demonstrate critical role for P2Y12Rs regulating through cellular translocation independent proliferation. These findings suggest patrol both process motility soma translocation.

Language: Английский

Citations

112