The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis

Cancers, Journal Year: 2021, Volume and Issue: 13(18), P. 4720 - 4720

Published: Sept. 21, 2021

Cancer-associated fibroblasts (CAFs) play a key role in cancer progression by contributing to extracellular matrix (ECM) deposition and remodeling, extensive crosstalk with cells, epithelial-to-mesenchymal transition (EMT), invasion, metastasis, therapy resistance. As metastasis is main reason for cancer-related deaths, it crucial understand the of CAFs this process. Colorectal (CRC) heterogeneous disease lethality especially common subtype CRC high stromal infiltration. A component stroma cancer-associated (CAFs). To provide new perspectives research on CAF-targeted therapeutics, CRC, we discuss mechanisms, crosstalk, functions involved CAF-mediated protection. This summary can serve as framework future studies elucidating these roles CAFs.

Language: Английский

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Hypoxia as a driver of resistance to immunotherapy

Drug Resistance Updates, Journal Year: 2021, Volume and Issue: 59, P. 100787 - 100787

Published: Nov. 18, 2021

Language: Английский

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Influencing factors and strategies of enhancing nanoparticles into tumors in vivo

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(8), P. 2265 - 2285

Published: March 24, 2021

The administration of nanoparticles (NPs) first faces the challenges evading renal filtration and clearance reticuloendothelial system (RES). After that, NPs infiltrate through expanded endothelial space penetrated dense stroma tumor microenvironment to cells. As long as possible prolong time remaining in tissue, release active agent induce pharmacological action. This review provides a comprehensive summary physical chemical properties influence various biological factors microenvironment, discusses how improve final efficacy adjusting characteristics structure NPs. Perspectives future directions are also provided.

Language: Английский

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Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 21, 2023

Abstract In recent years, tumor immunotherapy has made significant progress. However, immunotherapy, particularly immune checkpoint inhibitors (e.g., PD-1/PD-L1 inhibitors), benefits only a tiny proportion of patients in solid cancers. The microenvironment (TME) acts role immunotherapy. Studies reported that tumor-associated macrophages (TAMs), as one the main components TME, seriously affected therapeutic effect inhibitors. this review, we analyzed TAMs from epigenetic and single-cell perspectives introduced mechanisms anti-programmed death protein 1(anti-PD-1) therapy. addition, summarized combination regimens enhance efficacy elaborated on different Eventually, clinical value by influencing was discussed. These above are beneficial to elucidate poor tumors point view explore strategies improve its objective remission rate

Language: Английский

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The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape

Nature Immunology, Journal Year: 2021, Volume and Issue: 22(6), P. 769 - 780

Published: May 20, 2021

Language: Английский

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