Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Nov. 22, 2021
Circular
RNAs
(circRNAs)
are
a
class
of
single-stranded
covalently
closed
non-coding
without
5′
cap
structure
or
3′
terminal
poly
(A)
tail,
which
expressed
in
variety
tissues
and
cells
with
conserved,
stable
specific
characteristics.
Glioblastoma
(GBM)
is
the
most
aggressive
lethal
tumor
central
nervous
system,
characterized
by
high
recurrence
mortality
rates.
The
expression
circRNAs
GBM
has
demonstrated
their
potential
to
become
new
biomarkers
for
development
GBM.
shown
as
cell
proliferation,
apoptosis,
migration
invasion,
provides
ideas
treatment.
In
this
paper,
we
will
review
biological
properties
functions
roles
clinical
applications
Chinese Medical Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Abstract
Noncoding
RNAs
(ncRNAs)
are
a
class
of
RNA
molecules
with
little
or
no
protein-coding
potential.
Emerging
evidence
indicates
that
ncRNAs
frequently
dysregulated
and
play
pivotal
roles
in
the
pathogenesis
pancreatic
cancer.
Their
aberrant
expression
can
arise
from
chromosomal
abnormalities,
transcriptional
control,
epigenetic
modifications.
function
as
protein
scaffolds
molecular
decoys
to
modulate
interactions
between
proteins
other
biomolecules,
thereby
regulating
gene
contributing
cancer
progression.
In
this
review,
we
summarize
mechanisms
underlying
ncRNA
dysregulation
cancer,
emphasize
biological
significance
ncRNA–protein
interactions,
highlight
their
clinical
relevance.
A
deeper
understanding
is
essential
elucidate
advance
translational
research
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 11, 2022
Exosomes
are
small
nanoscale
vesicles
with
a
double-layered
lipid
membrane
structure
secreted
by
cells,
and
almost
all
types
of
cells
can
secrete
exosomes.
carry
variety
biologically
active
contents
such
as
nucleic
acids
proteins,
play
an
important
role
not
only
in
intercellular
information
exchange
signal
transduction,
but
also
various
pathophysiological
processes
the
human
body.
Surface-enhanced
Raman
Spectroscopy
(SERS)
uses
light
to
interact
nanostructured
materials
gold
silver
produce
strong
surface
plasmon
resonance
effect,
which
significantly
enhance
molecules
adsorbed
on
nanostructures
obtain
rich
fingerprint
sample
itself
or
probe
ultra-sensitivity.
The
unique
advantages
SERS,
non-invasive
high
sensitivity,
good
selectivity,
fast
analysis
speed,
low
water
interference,
make
it
promising
technology
for
life
science
clinical
testing
applications.
In
this
paper,
we
briefly
introduce
exosomes
current
main
detection
methods.
We
describe
basic
principles
SERS
progress
application
unlabeled
labeled
exosome
detection.
This
paper
summarizes
value
SERS-based
assays
early
tumor
diagnosis.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 10203 - 10203
Published: June 15, 2023
One
of
the
most
common
and
deadly
types
pancreatic
cancer
(PC)
is
ductal
adenocarcinoma
(PDAC),
with
patients
succumbing
to
disease
within
one
year
diagnosis.
Current
detection
strategies
do
not
address
asymptomatic
PC;
therefore,
are
diagnosed
at
an
advanced
stage
when
curative
treatment
often
no
longer
possible.
In
order
detect
PC
in
earlier,
risk
factors
that
could
serve
as
reliable
markers
need
be
examined.
Diabetic
mellitus
(DM)
a
significant
factor
for
this
malignancy
can
both
cause
consequence
PC.
Typically,
DM
caused
by
known
new-onset,
pancreatogenic,
pancreoprivic,
or
cancer-related
diabetes
(PCRD).
Although
PCRD
quite
distinct
from
type
2
(T2DM),
there
currently
biomarkers
differentiate
T2DM.
To
identify
such
biomarkers,
better
understanding
mechanisms
mediating
essential.
end,
has
been
growing
research
interest
recent
years
elucidate
role
tumour-derived
exosomes
their
cargo
pathogenesis
PCRD.
Exosomes
derived
tumours
recognized
specificity
because
they
reflect
characteristics
parent
cells
important
intercellular
communication.
Their
consists
proteins,
lipids,
nucleic
acids,
which
transferred
alter
behaviour
recipient
cells.
This
review
provides
concise
overview
current
knowledge
regarding
discusses
potential
areas
worthy
further
study.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Nov. 22, 2021
Circular
RNAs
(circRNAs)
are
a
class
of
single-stranded
covalently
closed
non-coding
without
5′
cap
structure
or
3′
terminal
poly
(A)
tail,
which
expressed
in
variety
tissues
and
cells
with
conserved,
stable
specific
characteristics.
Glioblastoma
(GBM)
is
the
most
aggressive
lethal
tumor
central
nervous
system,
characterized
by
high
recurrence
mortality
rates.
The
expression
circRNAs
GBM
has
demonstrated
their
potential
to
become
new
biomarkers
for
development
GBM.
shown
as
cell
proliferation,
apoptosis,
migration
invasion,
provides
ideas
treatment.
In
this
paper,
we
will
review
biological
properties
functions
roles
clinical
applications
