Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Feb. 23, 2023
Abstract
Pyroptosis
is
a
lytic
and
inflammatory
type
of
programmed
cell
death
that
mediated
by
Gasdermin
proteins
(GSDMs).
Attractively,
recent
evidence
indicates
pyroptosis
involves
in
the
development
tumors
can
serve
as
new
strategy
for
cancer
treatment.
Here,
we
present
basic
knowledge
pyroptosis,
an
overview
expression
patterns
roles
GSDMs
breast
cancer.
In
addition,
further
summarize
available
progression
give
insight
into
clinical
potential
applying
anticancer
strategies
This
review
will
deepen
our
understanding
relationship
between
cancer,
provide
novel
therapeutic
avenue
Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
31(1)
Published: Jan. 8, 2025
Abstract
Background
Predictive,
preventive,
and
personalized
medicine
(PPPM/3PM)
is
a
strategy
aimed
at
improving
the
prognosis
of
cancer,
programmed
cell
death
(PCD)
increasingly
recognized
as
potential
target
in
cancer
therapy
prognosis.
However,
PCD-based
predictive
model
for
serous
ovarian
carcinoma
(SOC)
lacking.
In
present
study,
we
to
establish
index
(CDI)–based
using
PCD-related
genes.
Methods
We
included
1254
genes
from
12
PCD
patterns
our
analysis.
Differentially
expressed
(DEGs)
Cancer
Genome
Atlas
(TCGA)
Genotype-Tissue
Expression
(GTEx)
were
screened.
Subsequently,
14
PCD-gene-based
CDI
model.
Genomics,
single-cell
transcriptomes,
bulk
spatial
clinical
information
TCGA-OV,
GSE26193,
GSE63885,
GSE140082
collected
analyzed
verify
prediction
Results
The
was
an
independent
prognostic
risk
factor
patients
with
SOC.
Patients
SOC
high
had
lower
survival
rates
poorer
prognoses
than
those
low
CDI.
Specific
parameters
combined
nomogram
that
accurately
assessed
patient
survival.
used
PCD-genes
observe
differences
between
groups.
results
showed
immunosuppression
hardly
benefited
immunotherapy;
therefore,
trametinib_1372
BMS-754807
may
be
therapeutic
agents
these
patients.
Conclusions
CDI-based
model,
which
established
genes,
predicted
tumor
microenvironment,
immunotherapy
response,
drug
sensitivity
Thus
this
help
improve
diagnostic
efficacy
PPPM.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
The
effectiveness
of
existing
systemic
and
targeted
therapies
remains
limited
in
triple-negative
breast
cancer
(TNBC)
treatment.
Much
research
has
been
conducted
on
reactive
oxygen
species
(ROS)-mediated
cell
death
to
overcome
the
shortcomings
currently
applied
chemotherapeutic
treatments.
Herein,
we
have
developed
novel
Ru(II)/Ir(III)-mediated
triazolylpyridine
complexes
as
ROS
inducers.
Upon
entering
TNBC
cells,
Ru(II)
complex
effectively
accumulated
mitochondria
triggered
creation
ROS,
facilitating
dysfunction
oxidative
DNA
damage,
ultimately
causing
cells
through
G2/M
phase
cycle
arrest.
Eventually,
this
induced
upregulation
BAX
(pro-apoptotic
protein)
downregulation
BCL-2
(antiapoptotic
caspase
3/9
pathway
released
cytochrome
c
cytosol
for
apoptosis.
JRu
(RuII
triazolylpyridine)
significantly
reduced
integrity
viability
3D
spheroids.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(4), P. 1488 - 1525
Published: Jan. 30, 2023
Abstract
Regulated
cell
death
(RCD)
refers
to
programmed
regulated
by
various
protein
molecules,
such
as
apoptosis,
autophagy‐dependent
death,
and
necroptosis.
Accumulating
evidence
has
recently
revealed
that
RCD
subroutines
have
several
links
many
types
of
human
cancer;
therefore,
targeting
with
pharmacological
small‐molecule
compounds
would
be
a
promising
therapeutic
strategy.
Moreover,
plant
natural
compounds,
synthesized
from
sources,
their
derivatives
been
widely
reported
regulate
different
improve
potential
cancer
therapy.
Thus,
in
this
review,
we
focus
on
updating
the
intricate
mechanisms
necroptosis
cancer.
further
discuss
representative
above‐mentioned
three
RCD,
candidate
drugs
for
future
treatment.
iScience,
Journal Year:
2023,
Volume and Issue:
26(11), P. 108218 - 108218
Published: Oct. 17, 2023
Triple-negative
breast
cancer
(TNBC)
poses
a
considerable
challenge
due
to
its
aggressive
nature.
Notably,
metal
ion-induced
cell
death,
such
as
ferroptosis,
has
garnered
significant
attention
and
demonstrated
potential
implications
for
cancer.
Recently,
cuproptosis,
potent
death
pathway
reliant
on
copper,
been
identified.
However,
whether
cuproptosis
can
be
targeted
treatment
remains
uncertain.
Here,
we
screened
the
US
Food
Drug
Administration
(FDA)-approved
drug
library
identified
zinc
pyrithione
(ZnPT)
compound
that
significantly
inhibited
TNBC
progression.
RNA
sequencing
revealed
ZnPT
disrupted
copper
homeostasis.
Furthermore,
facilitated
oligomerization
of
dihydrolipoamide
S-acetyltransferase,
landmark
molecule
cuproptosis.
Clinically,
high
expression
levels
cuproptosis-related
proteins
were
correlated
with
poor
prognosis
in
patients.
Collectively,
these
findings
indicate
induce
by
targeting
disrupting
homeostasis,
providing
experimental
foundation
exploring
target
discovery
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Feb. 23, 2023
Abstract
Pyroptosis
is
a
lytic
and
inflammatory
type
of
programmed
cell
death
that
mediated
by
Gasdermin
proteins
(GSDMs).
Attractively,
recent
evidence
indicates
pyroptosis
involves
in
the
development
tumors
can
serve
as
new
strategy
for
cancer
treatment.
Here,
we
present
basic
knowledge
pyroptosis,
an
overview
expression
patterns
roles
GSDMs
breast
cancer.
In
addition,
further
summarize
available
progression
give
insight
into
clinical
potential
applying
anticancer
strategies
This
review
will
deepen
our
understanding
relationship
between
cancer,
provide
novel
therapeutic
avenue
