Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(1), P. 229 - 260
Published: Feb. 19, 2024
Language: Английский
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(3), P. 848 - 863
Published: Jan. 1, 2024
Macrophages can be polarized into functional classically activated (M1) or alternatively (M2) phenotype. Tumor-associated macrophages (TAMs) mainly exhibit M2 Previous works determined that up-regulation of enolase 2 (ENO2) in diffuse large B-cell lymphoma (DLBCL) cells promote to an M2-like phenotype, thereby consequently promoting the progression DLBCL. Exosomes are a subset extracellular vesicles, carrying various bioactive molecules, mediate signals transduction and regulate immune cells. In our study, we investigated role related mechanisms DLBCL-derived exosomal ENO2 regulating macrophage polarization during DLBCL
Language: Английский
Citations
29
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 5, 2024
Abstract Diabetic wounds are characterized by incomplete healing and delayed healing, resulting in a considerable global health care burden. Exosomes lipid bilayer structures secreted nearly all cells express characteristic conserved proteins parent cell-associated proteins. harbor diverse range of biologically active macromolecules small molecules that can act as messengers between different cells, triggering functional changes recipient thus endowing the ability to cure various diseases, including diabetic wounds. accelerate wound regulating cellular function, inhibiting oxidative stress damage, suppressing inflammatory response, promoting vascular regeneration, accelerating epithelial facilitating collagen remodeling, reducing scarring. from tissues or potentially possess functions varying levels promote healing. For example, mesenchymal stem cell-derived exosomes (MSC-exos) have favorable potential field due their superior stability, permeability, biocompatibility, immunomodulatory properties. Exosomes, which derived skin components, modulate inflammation regeneration key turn promotes Therefore, this review mainly emphasizes roles mechanisms sources, represented MSCs improving A deeper understanding therapeutic will yield promising candidates perspectives for management.
Language: Английский
Citations
24
Nanoscale Advances, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Key challenges in exosomal based therapies.
Language: Английский
Citations
21
Clinical Medicine Insights Oncology, Journal Year: 2024, Volume and Issue: 18
Published: Jan. 1, 2024
Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, nucleic acids. Exosomes have been implicated in the development spread cancer, recent studies shown that their contents may be exploited as biomarkers for early detection ongoing surveillance disease. In this review article, we summarize current knowledge on cancer. We discuss various methods used exosome isolation characterization, well different types biomolecules found within relevant cancer diagnosis prognosis. also highlight demonstrated utility exosomal such lung breast pancreatic Overall, show great promise noninvasive monitoring. ability to transform diagnostic therapeutic paradigms, providing more efficient individualized. This seeks serve an inspiration new ideas research never-ending fight against Moreover, further needed validate clinical establish standardized protocols analysis. With continued development, potential revolutionize treatment.
Language: Английский
Citations
17
Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(1), P. 229 - 260
Published: Feb. 19, 2024
Language: Английский
Citations
17