International Journal of Oncology,
Journal Year:
2024,
Volume and Issue:
65(4)
Published: Aug. 30, 2024
The
use
of
antitumor
drugs
represents
a
reliable
strategy
for
cancer
therapy.
Unfortunately,
drug
resistance
has
become
increasingly
common
and
contributes
to
tumor
metastasis
local
recurrence.
immune
microenvironment
(TME)
consists
cells,
cytokines
immunomodulators,
collectively
they
influence
the
response
treatment.
Epigenetic
changes
including
DNA
methylation
histone
modification,
as
well
increased
exportation
have
been
reported
contribute
development
in
cancers.
In
past
few
years,
majority
studies
on
tumors
only
focused
progression
from
mechanistic
standpoint;
examined
whether
TME
can
also
affect
growth
resistance.
Recently,
emerging
evidence
raised
more
concerns
regarding
role
present
review,
it
was
discussed
how
suppressive
adapts
characterized
by
cooperation
cytokines,
stromal
cells
extracellular
matrix.
Furthermore,
reviewed
these
immunological
or
metabolic
alter
immuno‑surveillance
thus
facilitate
addition,
potential
targets
developing
novel
therapeutic
strategies
improve
individualized
therapy
treatment
were
revealed.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 2, 2023
Abstract
Despite
centuries
since
the
discovery
and
study
of
cancer,
cancer
is
still
a
lethal
intractable
health
issue
worldwide.
Cancer-associated
fibroblasts
(CAFs)
have
gained
much
attention
as
pivotal
component
tumor
microenvironment.
The
versatility
sophisticated
mechanisms
CAFs
in
facilitating
progression
been
elucidated
extensively,
including
promoting
angiogenesis
metastasis,
inducing
drug
resistance,
reshaping
extracellular
matrix,
developing
an
immunosuppressive
Owing
to
their
robust
tumor-promoting
function,
are
considered
promising
target
for
oncotherapy.
However,
highly
heterogeneous
group
cells.
Some
subpopulations
exert
inhibitory
role
growth,
which
implies
that
CAF-targeting
approaches
must
be
more
precise
individualized.
This
review
comprehensively
summarize
origin,
phenotypical,
functional
heterogeneity
CAFs.
More
importantly,
we
underscore
advances
strategies
clinical
trials
CAF
various
cancers,
also
progressions
immunotherapy.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 13, 2024
Abstract
Amino
acid
metabolism
plays
important
roles
in
tumor
biology
and
therapy.
Accumulating
evidence
has
shown
that
amino
acids
contribute
to
tumorigenesis
immunity
by
acting
as
nutrients,
signaling
molecules,
could
also
regulate
gene
transcription
epigenetic
modification.
Therefore,
targeting
will
provide
new
ideas
for
treatment
become
an
therapeutic
approach
after
surgery,
radiotherapy,
chemotherapy.
In
this
review,
we
systematically
summarize
the
recent
progress
of
malignancy
their
interaction
with
signal
pathways
well
effect
on
microenvironment
Collectively,
highlight
potential
application
future
expectation.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Jan. 17, 2024
Cancer
is
a
complex
disease
resulting
from
abnormal
cell
growth
that
induced
by
number
of
genetic
and
environmental
factors.
The
tumor
microenvironment
(TME),
which
involves
extracellular
matrix,
cancer-associated
fibroblasts
(CAF),
tumor-infiltrating
immune
cells
angiogenesis,
plays
critical
role
in
progression.
Cyclic
adenosine
monophosphate
(cAMP)
second
messenger
has
pleiotropic
effects
on
the
TME.
downstream
effectors
cAMP
include
cAMP-dependent
protein
kinase
(PKA),
exchange
activated
(EPAC)
ion
channels.
While
can
activate
PKA
or
EPAC
promote
cancer
growth,
it
also
inhibit
proliferation
survival
context-
type-dependent
manner.
Tumor-associated
stromal
cells,
such
as
CAF
release
cytokines
factors
either
stimulate
production
within
Recent
studies
have
shown
targeting
signaling
TME
therapeutic
benefits
cancer.
Small-molecule
agents
adenylate
cyclase
been
to
growth.
In
addition,
cAMP-elevating
agents,
forskolin,
not
only
induce
death,
but
directly
some
types.
this
review,
we
summarize
current
understanding
biology
immunology
discuss
basis
for
its
context-dependent
dual
oncogenesis.
Understanding
precise
mechanisms
interact
will
be
development
effective
therapies.
Future
aimed
at
investigating
cAMP-cancer
axis
regulation
may
provide
new
insights
into
underlying
tumorigenesis
lead
novel
strategies.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2023,
Volume and Issue:
42(1)
Published: March 10, 2023
Metabolic
reprogramming
is
one
of
the
hallmarks
cancer.
As
nutrients
are
scarce
in
tumor
microenvironment
(TME),
cells
adopt
multiple
metabolic
adaptations
to
meet
their
growth
requirements.
not
only
present
cells,
but
exosomal
cargos
mediates
intercellular
communication
between
and
non-tumor
TME,
inducing
remodeling
create
an
outpost
microvascular
enrichment
immune
escape.
Here,
we
highlight
composition
characteristics
meanwhile
summarize
components
corresponding
sorting
mode.
Functionally,
these
cargos-mediated
improves
"soil"
for
metastasis.
Moreover,
discuss
abnormal
metabolism
targeted
by
its
potential
antitumor
therapy.
In
conclusion,
this
review
updates
current
role
TME
enriches
future
application
scenarios
exosomes.
Cancer Letters,
Journal Year:
2023,
Volume and Issue:
566, P. 216234 - 216234
Published: May 24, 2023
Cancer-associated
fibroblasts
(CAFs)
are
abundant
and
important
components
of
the
tumour
mesenchyme,
have
been
extensively
studied
for
their
role
in
primary
tumours.
CAFs
provide
biomechanical
support
cells
play
key
roles
immunosuppression
metastasis.
can
promote
epithelial-mesenchymal
transition
(EMT)
by
secreting
extracellular
vesicles
(EVs),
increasing
adhesion
to
cells,
remodelling
matrix
(ECM)
tumour,
changing
its
mechanical
stiffness,
which
provides
a
pathway
Moreover,
form
cell
clusters
with
circulating
(CTCs)
help
them
resist
blood
shear
forces
achieve
colonisation
distant
host
organs.
Recent
studies
revealed
pre-metastatic
niche
(PMN)
formation
prevention.
In
this
review,
we
discuss
PMN
therapeutic
interventions
targeting
prevent
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(10)
Published: Oct. 30, 2023
Lymph
node
metastasis
(LNM)
is
the
prominent
route
of
gastric
cancer
dissemination,
and
usually
leads
to
tumor
progression
a
dismal
prognosis
cancer.
Although
exosomal
lncRNAs
have
been
reported
be
involved
in
development,
whether
secreted
can
encode
peptides
recipient
cells
remains
unknown.
Here,
we
identified
an
lncRNA
(lncAKR1C2)
that
was
clinically
correlated
with
lymph
VEGFC-independent
manner.
Exo-lncAKR1C2
from
demonstrated
enhance
tube
formation
migration
lymphatic
endothelial
cells,
facilitate
lymphangiogenesis
vivo.
By
comparing
metabolic
characteristics
LN
metastases
primary
focuses,
found
displayed
higher
lipid
activity.
Moreover,
exo-lncAKR1C2
encodes
microprotein
(pep-AKR1C2)
promotes
CPT1A
expression
by
regulating
YAP
phosphorylation,
leading
enhanced
fatty
acid
oxidation
(FAO)
ATP
production.
These
findings
highlight
novel
mechanism
LNM
suggest
encoded
lncAKR1C2
serves
as
therapeutic
target
for
advanced
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
Tumor
metastasis
represents
a
stepwise
progression
and
stands
as
principal
determinant
of
unfavorable
prognoses
among
cancer
patients.
Consequently,
an
in-depth
exploration
its
mechanisms
holds
paramount
clinical
significance.
Cancer-associated
fibroblasts
(CAFs),
constituting
the
most
abundant
stromal
cell
population
within
tumor
microenvironment
(TME),
have
garnered
robust
evidence
support
for
their
pivotal
regulatory
roles
in
metastasis.
Review
This
review
systematically
explores
CAFs
at
eight
critical
stages
tumorigenic
dissemination:
1)
extracellular
matrix
(ECM)
remodeling,
2)
epithelial-mesenchymal
transition
(EMT),
3)
angiogenesis,
4)
metabolism,
5)
perivascular
migration,
6)
immune
escape,
7)
dormancy,
8)
premetastatic
niche
(PMN)
formation.
Additionally,
we
provide
compendium
extant
strategies
aimed
targeting
therapy.
Key
Scientific
Concepts
delineates
structured
framework
interplay
between
while
furnishing
insights
potential
therapeutic
developments.
It
contributes
to
deeper
understanding
TME,
facilitating
utilization
CAF-targeting
therapies
anti-metastatic
approaches.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Sept. 2, 2024
Metabolic
reprogramming
provides
tumors
with
an
energy
source
and
biofuel
to
support
their
survival
in
the
malignant
microenvironment.
Extensive
research
into
intrinsic
oncogenic
mechanisms
of
tumor
microenvironment
(TME)
has
established
that
cancer-associated
fibroblast
(CAFs)
metabolic
regulates
progression
through
numerous
biological
activities,
including
immunosuppression,
chronic
inflammation,
ecological
niche
remodeling.
Specifically,
immunosuppressive
TME
formation
is
promoted
mediators
released
via
CAFs
multiple
immune
cells
collectively
thereby
inducing
pre-metastatic
formation,
ultimately
driving
a
vicious
cycle
proliferation
metastasis.
This
review
comprehensively
explores
process
regulation
dynamic
evolution
tumor-adapted
TME,
particular
focus
on
by
which
promote
Existing
findings
confirm
components
act
cooperatively
accelerate
events.
The
potential
applications
challenges
targeted
therapies
based
clinical
setting
are
further
discussed
context
advancing
related
CAFs.
