International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11954 - 11954
Published: Nov. 7, 2024
Lung cancer is the leading cause of cancer-related mortality worldwide, primarily driven by genetic mutations. The most common alterations implicated in lung include mutations
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 8, 2025
Golgi Protein 73 (GP73) is a Golgi-resident protein that highly expressed in primary tumor tissues. Initially identified as an oncoprotein, GP73 has been shown to promote development, particularly by mediating the transport of proteins related epithelial-mesenchymal transition (EMT), thus facilitating cell EMT. Though our previous review summarized functional roles intracellular signal transduction and its various mechanisms promoting EMT, recent studies have revealed plays crucial role regulating immune microenvironment. can modulate signaling pathways influence cytokine chemokine networks, resulting inflammation caused viral bacterial infection or diseases, leading microenvironment deteriorated. Additionally, extracellular also regulate target cells binding their cell-surface receptors entering acceptor cells, thereby development. In this review, we aim summarize findings, providing insights for future investigations on potential therapeutic ameliorating chronic
Language: Английский
Citations
1
Research, Journal Year: 2025, Volume and Issue: 8
Published: Jan. 1, 2025
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270
Published: Feb. 12, 2025
The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.
Language: Английский
Citations
1
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 664, P. 124583 - 124583
Published: Aug. 15, 2024
Language: Английский
Citations
5
Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(3), P. 345 - 356
Published: Sept. 1, 2024
Language: Английский
Citations
5
Cancer Letters, Journal Year: 2024, Volume and Issue: 611, P. 217385 - 217385
Published: Dec. 6, 2024
Language: Английский
Citations
5
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114611 - 114611
Published: April 8, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 18, 2025
Seven compounds were isolated from ethyl acetate extract of Alcea rosea and examined for their cytotoxicity against HCT116, HT29 SW480 colon cancer cells. It was found that two (C4 C5) exhibited strong anti-colon activities. These used to study properties include MTT activity (with IC50 C4 as 74.71, 129.0 131.4 µg/ml in respectively, whereas C5 128.1, 168.4 225.8 cells respectively), colony formation activity, wound healing spheroid DAPI-PI staining, acridine-orange ethidium bromide ROS measurement, rhodamine-123 staining both HCT116 Both the showed significant increase apoptosis visualized by 4′,6-diamidino-2-phenylindol/propidium iodide (DAPI-PI) acridine orange/ethidium (AO/EtBr) staining. The induction further confirmed expressions cleaved PARP caspase 3. generation its effect on MMP measured with Dichloro-dihydro-fluorescein diacetate (DCFH-DA) Rhodamine. Expression levels EMT associated markers like Cyclin D1, Slug, Vimentin, E-Cadherin also studied. down regulate protein Vimentin a concentration-dependent manner. Eeffect key signaling Wnt3a, Notch1, Shh evaluated. Additionally, mRNA these genes analyzed. best binding affinity when docked Wnt3a Notch1. Similarly, − 8.8, -8.2 7.6 kcal⋅mol− 1 Shh, present findings provide insight immense scientific support integrity piece indigenous knowledge. However, validation living organisms is necessary before progressing clinical trials advancing it into marketable pharmaceutical product.
Language: Английский
Citations
0
Cellular Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Tumor-infiltrating myeloid cells (TIMs), which encompass tumor-associated macrophages (TAMs), neutrophils (TANs), myeloid-derived suppressor (MDSCs), and dendritic (TADCs), are of great importance in tumor microenvironment (TME) integral to both pro- anti-tumor immunity. Nevertheless, the phenotypic heterogeneity functional plasticity TIMs have posed challenges fully understanding their complexity roles within TME. Emerging evidence suggested that presence is frequently linked prevention cancer treatment improvement patient outcomes survival. Given pivotal function TME, recently been recognized as critical targets for therapeutic approaches aimed at augmenting immunostimulatory cell populations while depleting or modifying those immunosuppressive. This review will explore important properties related immunity, angiogenesis, metastasis. We also document latest strategies targeting preclinical clinical settings. Our objective illustrate potential immunological may improve existing treatments.
Language: Английский
Citations
0
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 339 - 339
Published: March 13, 2025
Plant-based stilbenes are low-molecular-weight polyphenolic compounds that exhibit anti-oxidant, anti-microbial, anti-fungal, anti-inflammatory, anti-diabetic, cardioprotective, neuroprotective, and anti-cancer activities. They phytoalexins produced in diverse plant species response to stress, such as fungal bacterial infections or excessive UV irradiation. Plant-derived dietary products containing common components of the human diet. Stilbenes appear be promising chemopreventive chemotherapeutic agents. Accumulating evidence indicates able trigger both apoptotic autophagic molecular pathways many cancer cell lines. Of note, crosstalk between autophagy apoptosis under cellular stress conditions determines fate. The relationship is complex depends on context, e.g., type level. Apoptosis a regulated death, whereas may act pro-survival pro-death mechanism depending context. interplay have an important impact chemotherapy efficiency. This review focuses vitro effects different lines concerning apoptosis.
Language: Английский
Citations
0