International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11954 - 11954
Published: Nov. 7, 2024
Lung cancer is the leading cause of cancer-related mortality worldwide, primarily driven by genetic mutations. The most common alterations implicated in lung include mutations
Language: Английский
Published: Oct. 22, 2024
Gastrointestinal (GI) cancers are the most common causes of global cancer burden and cancer-related deaths. Chronic inflammation is a hallmark feature GI tumors plays an important role in tumor initiation, progression, therapeutic response. The genetic makeup cell, as well epigenetic alterations, biological processes constitute inflammatory microenvironment (TME) that provides essential nich for initiation progression. Cancer-associated inflammation, key component TME, displays protumoral or antitumoral activity depending on composition, spatial distribution, functional status immune cells involved, thus adversely affecting response to treatment clinical outcomes, whereas acute supports T-cell priming, activation, infiltration into malignant tissues, thereby conferring anti-tumoral immunity. Inflammatory proinflammatory molecules within TME act bridge between cancer. majority involved process innate cells, which play critical shapping both cellular composition plasticity stromal cells. Activation initiates production inflammatory, regenerative, anti-inflammatory soluble molecules, resulting adaptive Additionally, aberrant activation intracellular signaling pathways, metabolites have roles development healing during carcinogenesis. may inhibit effectiveness anti-cancer agents by causing enzymatic degradation drugs modulating immun activity, survival patient. In this review article, we highlight mechanisms formation cancers, cell-immune cell interactions, implications all these outcomes. We also comprehensively address linking chronic cancer, with focus frequent cancers.
Language: Английский
Citations
1
Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(3), P. 1907 - 1929
Published: July 2, 2024
Language: Английский
Citations
0
Chemistry Africa, Journal Year: 2024, Volume and Issue: 7(8), P. 4311 - 4323
Published: Oct. 1, 2024
Abstract This study aimed at studying phytochemical composition, nutritional properties and biological activities (antioxidant anti-inflammatory) of two potato varieties (sweet (SP): Ipomoea batatas L. conventional (CP): Solanum tuberosum L.) planted consumed in Morocco. For this, samples (SP CP) were firstly subjected to analysis, including water content, total reducing sugars, proteins, lipids, vitamin C, carotenoids, phenolic compounds flavonoids. Secondly, extracts namely antioxidant invitro anti-inflammatory. Potato activity was tested by DPPH capacity (TAC) methods. Proteins lipids contents found much higher SP (5.21 ± 0.26 0.29 0.02 g/100g DW) respectively than CP (2.93 0.15 0.11 0.01 respectively. Besides, sugars 16.65 2.53 DW the CP, 12.47 2.13 SP, The different be those using TAC These findings could explained richness carotenoids (212 10.60 mg/100g DW), (130.11 6.51 mg GAE/100g flavonoids (85.03 4.2 5mg QE/100g C (471.33 23.57 DW). Exclusion chromatography done Sephadex G50 showed that polymeric more abundant when compared monomeric ones. difference consistent with anti-inflammatory assessed vitro.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11954 - 11954
Published: Nov. 7, 2024
Lung cancer is the leading cause of cancer-related mortality worldwide, primarily driven by genetic mutations. The most common alterations implicated in lung include mutations
Language: Английский
Citations
0