Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

Disulfidptosis is a newly discovered form of cell death associated with tumorigenesis, particularly under oxidative stress and metabolic disorder conditions. Currently, the biological mechanisms disulfidptosis-related genes (DRGs) in head neck squamous carcinoma (HNSCC) remain unclear. The study includes sections on methodologies, data sources, clinical collection, subtype establishment, identification analysis differentially expressed genes, genetic variation, construction validation DRG prognostic model. Various analyses are conducted, including relationship between risk scores model clinicopathological features, immune status, checkpoints, tumor mutational burden (TMB), microsatellite instability (MSI), ESTIMATE, mRNAsi, drug sensitivity. also covers single-cell DNA methylation DRGs, prediction potential microRNA long non-coding RNA target genes. Prognostic DRGs expression HNSCC validated through RT-qPCR immunohistochemistry. model's predictive capability confirmed using external cohorts from GEO datasets tissue samples. role DSTN further gene knockout experiments. We identified four valuable (SLC3A2, NUBPL, ACTB, DSTN) constructed model, along identifying two DRG-related subtypes. Analysis score revealed that low-risk group had better prognosis compared to high-risk group. Significant correlations were found immunotherapy response, sensitivity, related epigenetic modifications. Low-risk patients as beneficiaries checkpoint inhibitor (ICI) therapy. A regulatory axis involving DSTN, hsa-miR-181c-5p, LUCAT1, IGFL2-AS1 was for HNSCC. IHC upregulation demonstrated excellent performance patients. Additionally, significantly overexpressed cells; its knockdown inhibited proliferation, migration, invasion. effectively predicts outcomes, promotes growth, inhibits

Language: Английский

---

Deciphering Epigenetic and Post-Translational Modifications in Ferroptosis: A Scientometric and Visualization Study

International Journal of Medical Sciences, Journal Year: 2025, Volume and Issue: 22(3), P. 508 - 527

Published: Jan. 1, 2025

Background: Recent research emphasizes the significant regulatory functions of epigenetic alterations and post-translational modifications (PTMs) in ferroptosis process. Despite existing volume literature, there is a remarkable shortage comprehensive analyses that systematically trace evolution research, map key investigative routes, evaluate current situation field, determine central themes, predict future directions. This study intends to offer summary progress achieved during past 12 years comprehending how PTMs regulate ferroptosis. Methods: The dataset originated from Web Science, covering period January 1, 2012, May 21, 2024. By employing advanced analytical tools, we carried out an extensive scientometric assessment combination with detailed visual data analysis. Results: results emphasize crucial role China, which contributes 69.59% global output, thereby demonstrating its influence on trajectory this domain. Remarkable productivity manifested at institutions such as Central South University, Shanghai Jiao Tong Zhejiang University. Liu Shuang Tang Daolin stand most productive authors field. journal Cell Death & Disease leads terms publication volume, having published greatest number articles related area. identified hepatocellular carcinoma, mitochondrial diseases, iron overload prominent diseases explored Conclusion: meticulous beneficial both experienced researchers newcomers by providing essential information facilitating derivation innovative concepts

Language: Английский

---

Cross-talks of GSH, mitochondria, RNA m6A modification, NRF2, and p53 between ferroptosis and cuproptosis in HCC: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140523 - 140523

Published: Feb. 1, 2025

Language: Английский

---

Cell death pathways: molecular mechanisms and therapeutic targets for cancer

MedComm, Journal Year: 2024, Volume and Issue: 5(9)

Published: Sept. 1, 2024

Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.

Language: Английский

---

Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 30, 2024

In the realm of cancer research, tumor microenvironment (TME) plays a crucial role in initiation and progression, shaped by complex interactions between cells surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted various cellular constituents within TME, including immune cells, cancer-associated fibroblasts, themselves. These cytokines facilitate intricate communication networks that significantly influence initiation, metastasis, suppression. Pyroptosis contributes to TME remodeling promoting release pro-inflammatory sustaining chronic inflammation, impacting processes such escape angiogenesis. However, challenges remain due interplay among cytokines, pyroptosis, along with dual effects pyroptosis on progression therapy-related complications like cytokine syndrome. Unraveling these complexities could strategies balance inflammatory responses while minimizing tissue damage during therapy. This review delves into crosstalk elucidating their contribution metastasis. By synthesizing emerging therapeutic targets innovative technologies concerning this aims provide novel insights enhance treatment outcomes for patients.

Language: Английский

---

Sonodynamic Activated Nanoparticles with Glut1 Inhibitor and Cystine-containing Polymer Stimulate Disulfidptosis for Improved Immunotherapy in Bladder Cancer

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123178 - 123178

Published: Feb. 8, 2025

Language: Английский

---

Machine learning predicts cuproptosis-related lncRNAs and survival in glioma patients

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 27, 2024

Language: Английский

---

Programmed cardiomyocyte death in myocardial infarction

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

---

Cuproptosis Nanoprodrug-Initiated Self-Promoted Cascade Reactions for Postoperative Tumor Therapy

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123176 - 123176

Published: Feb. 7, 2025

Language: Английский

---

The complexities of cell death mechanisms: a new perspective in systemic sclerosis therapy

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Language: Английский

---