Dying to survive: harnessing inflammatory cell death for better immunotherapy

Trends in cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

---

Novel Epitranscriptomic and Epigenetic Therapeutic Strategies and Targets for Ferroptosis in Liver Fibrosis

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 996, P. 177344 - 177344

Published: Feb. 25, 2025

Language: Английский

---

Targeting novel regulated cell death: disulfidptosis in cancer immunotherapy with immune checkpoint inhibitors

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 26, 2025

Abstract The battle against cancer has evolved over centuries, from the early stages of surgical resection to contemporary treatments including chemotherapy, radiation, targeted therapies, and immunotherapies. Despite significant advances in treatment recent decades, these therapies remain limited by various challenges. Immune checkpoint inhibitors (ICIs), a cornerstone tumor immunotherapy, have emerged as one most promising advancements treatment. Although ICIs, such CTLA-4 PD-1/PD-L1 inhibitors, demonstrated clinical efficacy, their therapeutic impact remains suboptimal due patient-specific variability immune resistance. Cell death is fundamental process for maintaining tissue homeostasis function. Recent research highlights that combination induced regulatory cell (RCD) ICIs can substantially enhance anti-tumor responses across multiple types. In cells exhibiting high levels recombinant solute carrier family 7 member 11 (SLC7A11) protein, glucose deprivation triggers programmed (PCD) pathway characterized disulfide bond formation REDOX (reduction-oxidation) reactions, termed “disulfidptosis.” Studies suggest disulfidptosis plays critical role efficacy SLC7A11 cancers. Therefore, investigate potential synergy between this study will explore mechanisms both processes progression, with goal enhancing response targeting intracellular pathway.

Language: Английский

---

Integrative Analysis of Cuproptosis‐Related Mitochondrial Depolarisation Genes for Prognostic Prediction in Non‐Small Cell Lung Cancer

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(4)

Published: Feb. 1, 2025

ABSTRACT In this research, we conducted an in‐depth analysis of differentially expressed genes associated with mitochondrial depolarisation in non‐small cell lung cancer (NSCLC) using single‐cell sequencing. By combining our findings cuproptosis‐related genes, identified 10 significant risk genes: DCN, PTHLH, CRYAB, HMGCS1, DSG3, ZFP36L2, SCAND1, NUDT4, NDUFA4L2 and RPL36A, univariate Cox regression machine learning methods. These form the core prognosis prediction model, which demonstrated high specificity accuracy predicting patient outcomes, as evidenced by ROC curve analysis. Kaplan–Meier curves further confirmed that patients low‐risk group had significantly better survival rates compared to those high‐risk group. Our models also provided valuable insights into tumour microenvironment, immunotherapy sensitivity chemotherapy response. To facilitate quantification probability survival, incorporated clinical data a nomogram. We comprehensively analysed mutation status expression patterns bulk transcriptomic, spatial transcriptomic datasets. Drug target predictions highlighted DCN promising therapeutic targets. Notably, RPL36A emerged potential marker for NSCLC, its validated lines through qPCR. This study has established predictive based on cuproptosis, aiding clinicians forecasting overall guiding personalised treatment strategies. The identification novel markers paved way targeted therapies, targets are critical advancing NSCLC.

Language: Английский

---

Lactylation and regulated cell death

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(4), P. 119927 - 119927

Published: Feb. 28, 2025

Language: Английский

---

METTL3/YTDHF1 Stabilizes MTCH2 mRNA to Regulate Ferroptosis in Glioma Cells

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 14, 2025

Background: Gliomas are aggressive brain tumors known for their poor prognosis and resistance to standard treatment options. Ferroptosis is an iron-dependent form of regulated cell death that has emerged as a promising target cancer treatment. This study examined how the methyltransferase-like 3/YTH domain family protein 1 (METTL3/YTHDF1) axis influences ferroptosis glioma progression by stabilizing mitochondrial carrier homolog 2 (MTCH2) messenger RNA (mRNA). Methods: MTCH2 expression in tissues lines was evaluated through quantitative real-time polymerase chain reaction (PCR) western blot analyses. To assess effects knockdown overexpression on functions, we performed series functional assays, including viability, colony formation, measurements lipid reactive oxygen species (lipid ROS) malondialdehyde (MDA) levels. Additionally, conducted immunoprecipitation (RIP) stability assays explore underlying mechanisms governing interaction between METTL3, YTHDF1, mRNA. Results: significantly upregulated lines. Silencing resulted decreased proliferation induced ferroptosis, evidenced increased peroxidation ROS accumulation. Conversely, enhanced survival reduced ferroptosis. METTL3-mediated N6-methyladenosine (m6A) modification mRNA enabling YTHDF1 bind protect modified from degradation. Conclusion: The METTL3/YTHDF1/MTCH2 plays critical role inhibiting promoting tumor survival. Targeting this pathway may provide new effective strategy patients.

Language: Английский

---

Hetero‐Trimetallic Atom Catalysts Enable Targeted ROS Generation and Redox Signaling for Intensive Apoptosis and Ferroptosis

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract Reactive oxygen species (ROS) play crucial roles in cellular metabolic processes by acting as primary intracellular chemical substrates and secondary messengers for signal modulation. However, the artificial engineering of nanozymes to generate ROS is restricted their low catalytic efficiency, high toxicity, off‐target consumption. Herein, hetero‐trimetallic atom catalysts (TACs) anchored on a stable symmetrical pyramid structure are designed presence N P surface ligands from cross‐linked polyphosphazene interlayer‐coated MIL‐101(Fe). The 3D network TACs with uniform dispersion Cu, Co, Fe hetero‐single atoms effectively tailor active sites avoid metal sintering, thereby providing sufficient activity blooms. Nanovesicle membranes facilitate accumulation homologous targeting, recognition, endocytosis, addressing potentially toxicity defects. Therefore, outcome situ ROS‐bloom acts redox directly regulating oxidative stress tumor microenvironment. Meanwhile, intervene glutathione peroxidase 4, long‐chain acyl‐CoA synthetase cysteinyl aspartate specific proteinase‐3 pathways second messengers, fostering proclivity toward apoptosis lipid peroxidation‐regulated ferroptosis pathway concurrently, highlighting application prospects biomedical field.

Language: Английский

---

A triboelectric-field-mediated cuproptosis induction patch for melanoma recurrence suppression

Matter, Journal Year: 2025, Volume and Issue: unknown, P. 102088 - 102088

Published: March 1, 2025

Language: Английский

---

Analysis of human brain RNA-seq data reveals combined effects of 4 types of RNA modifications and 18 types of programmed cell death on Alzheimer’s disease

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 3, 2025

Language: Английский

---

Epigenetic Landscapes Drive CAR-T Cell Kinetics and Fate Decisions: Bridging Persistence and Resistance

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104729 - 104729

Published: April 1, 2025

Language: Английский

---