Science Bulletin, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
The Lancet Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
4
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Dec. 26, 2024
Immune checkpoint inhibitors (ICIs) have dramatically transformed the treatment landscape for various malignancies, achieving notable clinical outcomes across a wide range of indications. Despite these advances, resistance to immune blockade (ICB) remains critical challenge, characterized by variable response rates and non-durable benefits. However, growing research into complex intrinsic extrinsic characteristics tumors has advanced our understanding mechanisms behind ICI resistance, potentially improving outcomes. Additionally, robust predictive biomarkers are crucial optimizing patient selection maximizing efficacy ICBs. Recent studies emphasized that multiple rational combination strategies can overcome enhance susceptibility ICIs. These findings not only deepen tumor biology but also reveal unique action sensitizing agents, extending benefits in cancer immunotherapy. In this review, we will explore underlying ICIs, discuss significance microenvironment (TIME) biomarkers, analyze current outline alternative effectiveness including personalized
Language: Английский
Citations
10
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217459 - 217459
Published: Jan. 1, 2025
Language: Английский
Citations
1
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 725 - 725
Published: Feb. 5, 2025
The genus Seseli L. (Apiaceae family) is widespread across Europe and Asia, with ten species identified in Georgia. Among these, foliosum (Somm. et Levier) Manden., notable for its unique pharmacological properties. To our knowledge, comprehensive phytochemical biological investigations have not yet been conducted. primary aim of this research to explore the chemical properties S. foliosum, thereby enhancing potential applications medicine related fields. Different chromatographic techniques were utilized isolate individual compounds identify composition MeOH Et2O extracts from seeds roots. A battery assays (antimicrobial, antioxidant, enzymatic, anxiolytic, cytotoxic) employed assess extracts. results gas chromatography mass spectrometry (GC/MS) revealed that both contain a diverse array compounds, including monoterpenoids, sesquiterpenoids, phenolic compounds. Furanocoumarin edultin was isolated extract by liquid–liquid separation (LLS). exhibited important enzyme inhibitory, antimicrobial activities efficacy against Staphylococcus aureus (MIC 125 µg/mL) Candida glabrata 62.5 µg/mL). Underground showed advanced cytotoxic activity, particularly hypopharyngeal carcinoma cells (CC50 22.33 µg/mL 27.16 µg/mL, respectively). study provides wide-range analysis highlighting as source bioactive These findings contribute understanding therapeutic lay groundwork further clinical research.
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101782 - 101782
Published: April 19, 2025
Language: Английский
Citations
1
Cancer Immunology Immunotherapy, Journal Year: 2024, Volume and Issue: 73(11)
Published: Sept. 13, 2024
Gastric cancer (GC) is a highly heterogeneous disease with complex tumor microenvironment (TME) that encompasses multiple cell types including cells, immune stromal and so on. Cancer-associated cells could remodel the TME influence progression of GC therapeutic response. Single-cell RNA sequencing (scRNA-seq), as an emerging technology, has provided unprecedented insights into complicated biological composition characteristics at molecular, cellular, immunological resolutions, offering new idea for studies. In this review, we discuss novel findings from scRNA-seq datasets revealing origin evolution GC, powerful tool investigating transcriptional dynamics intratumor heterogeneity (ITH) in GC. Meanwhile, demonstrate vital within TME, T B macrophages, play important role progression. Additionally, also overview how facilitates our understanding about effects on individualized therapy patients. Spatial transcriptomes (ST) have been designed to determine spatial distribution capture local intercellular communication networks, enabling further relationship between background particular its functions. summary, other single-cell technologies provide valuable perspective molecular pathological hold promise advancing basic research clinical practice
Language: Английский
Citations
6
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114047 - 114047
Published: Jan. 19, 2025
Language: Английский
Citations
0
Bioengineering, Journal Year: 2025, Volume and Issue: 12(2), P. 187 - 187
Published: Feb. 16, 2025
Digital pathology images have long been regarded as the gold standard for cancer diagnosis in clinical medicine. A highly generalized digital pathological image system can provide strong support diagnosis, help to improve diagnostic efficiency and accuracy of doctors, has important research value. The whole slide different centers lead very large staining differences due scanners dyes, which pose a challenge generalization performance model application multi-center data testing. In order achieve normalization data, this paper proposes style transfer algorithm based on an adversarial generative network high-resolution images. gradient-guided dye migration proposed introduces gradient-enhanced regularized term loss function design algorithm. was applied source multi-example learning domain significantly improved by validation datasets two centers. method AUC best classification from 0.8856 0.9243, another set experiments 0.8012 0.8313.
Language: Английский
Citations
0
Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 270 - 270
Published: Feb. 25, 2025
Background: Barrett’s esophagus (BE) is described by the transformation of normal squamous epithelium into metaplastic columnar epithelium, driven chronic gastroesophageal reflux disease (GERD). BE a recognized premalignant condition and main precursor to esophageal adenocarcinoma (EAC). Understanding molecular mechanisms underlying carcinogenesis crucial for improving prevention, surveillance, treatment strategies. Methods: This narrative review examines abnormalities associated with progression EAC. Results: study highlights inflammatory, genetic, epigenetic, chromosomal alterations, emphasizing key pathways biomarkers. follows multistep process involving dysplasia genetic alterations such as TP53 CDKN2A (p16) mutations, instability, dysregulation like PI3K/AKT/mTOR. Epigenetic including aberrant microRNA expression or DNA methylation, further contribute this progression. These changes are stage-specific, some occurring early in during transition high-grade Innovations chemoprevention, combining proton pump inhibitors aspirin, potential antireflux surgery halt promising. Incorporating biomarkers surveillance strategies advancing precision medicine may enable earlier detection personalized treatments. Conclusions: primary preneoplastic A deeper understanding its can enhance protocols, optimize management inflammation, refine prevention therapeutic strategies, ultimately contributing reduction global burden
Language: Английский
Citations
0
Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0