Science Bulletin, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114261 - 114261
Published: Feb. 26, 2025
Language: Английский
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Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Feb. 26, 2025
Chemoresistance is a critical factor compromising the survival of patients with colorectal cancer (CRC). The "Zhi-Zhen" formula (ZZF), traditional prescription developed by Chinese national medicine masters, has been extensively used in clinical practice to treat gastrointestinal cancer. Notably, ZZF potential enhance tumor sensitivity chemotherapy. Although previous vitro studies have demonstrated efficacy overcoming chemoresistance (CRC), its precise molecular mechanisms remain poorly understood. We an integrated approach bioinformatics and network pharmacology predict active ingredients targets alleviating chemoresistance. top five identified degree analysis were validated using mass spectrometry. then established oxaliplatin-resistant CRC cell model explore regulatory through which overcomes at cellular level. Network analyses jointly 29 compounds 13 key ZZF, associated Among these targets, differential expression CASP7 significantly affected progression-free CRC. two lines observed upregulation resistant cells. Furthermore, increases activation cells, promoting apoptosis, thereby ameliorating Additionally, β-catenin knockdown led expression, whereas Wnt/β-catenin signaling pathway reduced protein levels. decreases activity decreasing transcription nuclear localization. value treatment inhibiting localization β-catenin, increasing enhancing apoptotic response chemoresistant
Language: Английский
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Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(6)
Published: March 1, 2025
ABSTRACT Background Bone metastases are highly refractory and associated with extremely poor survival. Despite the increasing incidence of bone metastasis in gastric cancer (GC), comprehensive analyses regarding clinicopathological features, prognosis, treatment bone‐metastatic GC remain limited. Methods We obtained data from 120 patients Nanjing Drum Tower Hospital 36,139 SEER database. Chi‐square Mann–Whitney U ‐tests evaluated while Cox models identified prognostic factors. Kaplan–Meier curves forest plots assessed effects different strategies on overall survival after (OS‐BM). Results Among patients, 55 (45.83%) were diagnosed poorly cohesive carcinoma (PCC). The higher was also observed SRCC database ( p < 0.0001). PCC exhibited distinct pathological features compared to non‐PCC including lower PD‐L1 = 0.042) E‐cadherin expression 0.049). Multivariate analysis various negative factors such as metachronous 0.001, HR 2.35, 95% CI:1.47–3.74) CA125 0.036, 1.60, CI:1.03–2.48), whereas immunotherapy a positive factor 0.44, CI:0.29–0.66). Subgroup showed improved among populations receiving immunotherapy. Moreover, combinational therapies other treatments (anti‐angiogenic therapy and/or local radiotherapy) further patient OS‐BM. Conclusion Our results suggest exhibit high PCC. Immunotherapy‐based combination offer benefits, thus supporting application at risk metastasis.
Language: Английский
Citations
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Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: April 8, 2025
Despite the growing number of studies on role gut microbiota in treating gastrointestinal tumors, overall research trends this field remain inadequately characterized. A bibliometric analysis was conducted using publications retrieved from Web Science Core Collection (up to September 30, 2024). Analytical tools including VOSviewer, CiteSpace, and an online platform were employed evaluate hotspots. Analysis 1,421 revealed significant geographical disparities output, with China United States leading contributions. Institutionally, University Adelaide, Zhejiang University, Shanghai Jiao Tong prominent contributors. Authorship identified Hannah R. Wardill as most prolific author, while International Journal Molecular Sciences emerged a journal. Rapidly frontiers include "proliferation," "inhibition," "immunotherapy," "drug delivery," "tumorigenesis." This study provides comprehensive overview highlights emerging directions, aiming advance scientific clinical applications tumor therapy.
Language: Английский
Citations
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Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: April 11, 2025
Background Gastric adenosquamous carcinoma (ASC) is an exceedingly rare neoplasm. Its infrequent occurrence has resulted in sparse literature on its diagnosis and management, presenting considerable challenges for clinical practice. Case presentation A 70-year-old male presented with epigastric pain and, upon gastroscopy CT imaging, was found to have a mass the gastric antrum. Histopathological analysis confirmed of carcinoma. Immunohistochemical staining revealed loss PMS2 MLH-1 expression, while molecular methylation, suggesting microsatellite instability-high (MSI-H) phenotype. The PD-L1 combined positive score (CPS) remarkably elevated at 80. Postoperatively, patient received six cycles oxaliplatin conjunction PD-1 inhibitor therapy. At one-year follow-up, remained long-term remission, no evidence recurrence. Conclusion This case underscores potential efficacy integrating surgery, chemotherapy, immunotherapy managing ASC, particularly context MSI-H expression. It further emphasizes critical role comprehensive profiling guiding personalized therapeutic strategies such malignancies. Further research additional reports are imperative establish optimal management protocols ASC enhance outcomes.
Language: Английский
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Therapeutic Advances in Gastroenterology, Journal Year: 2025, Volume and Issue: 18
Published: April 1, 2025
The immunotherapy landscape for gastrointestinal (GI) tumors is rapidly evolving. There an urgent need reliable biomarkers capable of predicting treatment outcomes to optimize therapeutic strategies and enhance patient prognosis. This review presents a comprehensive overview associated with the response GI tumors, covering advances in molecular genetics, histopathological markers, imaging. Key biomarkers, such as microsatellite instability, tumor mutational burden, programmed death-ligand 1 expression, remain critical identifying patients likely benefit from immune checkpoint inhibitors. significance tumor-infiltrating lymphocytes, notably CD8+ T cell regulatory ratio, predictor explored. In addition, advanced imaging techniques, including computed tomography (CT), magnetic resonance imaging, positron emission tomography-CT, facilitate noninvasive evaluation biology response. By bridging data, this integrated strategy enhances precision selection, monitoring, adaptive therapy design. Future studies should aim validate these larger, multicenter cohorts focus on clinical translation advance medicine oncology.
Language: Английский
Citations
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BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 29, 2025
Artificial intelligence (AI) networks offer significant potential for predicting immunotherapy outcomes in gastrointestinal cancers by analyzing genetic mutation profiles. Their application prognosis remains underexplored. This systematic review and meta-analysis aim to evaluate the effectiveness of AI-based models, which refers systems utilizing artificial analyze data make predictions, responses using features. study, adhering PRISMA guidelines, aimed AI cancer response A search PubMed, WOS, Scopus identified relevant studies. Data extraction quality assessment were conducted, statistical analysis included pooled estimates sensitivity, specificity, accuracy, AUC. Regression models imputation methods addressed missing values, ensuring accurate robust results. STATA version 18 was used data. total 45 studies, all published 2024, involving 14,047 participants training sets 10,885 test sets, included. The results model performance based on features were: AUC = 0.86 (95% CI: 0.86-0.87), Sensitivity 83% 83%-84%), Specificity 72% 72%-73%), Accuracy 82% 82%-83%). Heterogeneity low moderate, no publication bias detected. Subgroup showed higher gastric (AUC: 0.87) lower pancreatic 0.52). demonstrate promising highlights their stratifying patients optimizing treatment decisions. However, further large-scale studies are needed validate integrate them into clinical practice improved precision immunotherapy.
Language: Английский
Citations
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Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: May 8, 2025
As one of the most common gastrointestinal tumors, Gastric Cancer (GC) poses a serious threat to human health due its high morbidity and mortality. The current treatment strategy is comprehensive program mainly based on surgery, especially for advanced GC patients. emergence immune checkpoint inhibitors has completely changed this status quo, synergistic effect neoadjuvant immunotherapy combined with chemotherapy significantly improved resection radical rate overall survival patients local GC. We present case locally (cT4N0Mx) microsatellite instability (MSI-H) PD-L1 Combined Positive Score (CPS)=2. patient received therapy Sintilimab FOLFOX (folinic acid (leucovorin), 5-fluorouracil (5-FU), oxaliplatin), reduced tumor volume after 3 cycles treatment. Then she underwent subtotal gastrectomy gastrojejunostomy D2 lymph node dissection. postoperative pathological results showed that no cancerous tissue remained in tissue, pathologic complete response (pCR) was achieved. first cycle adjuvant same protocol surgery. During therapy, experienced side effects such as dyspepsia, nausea mild myelosuppression. Therefore, potential be an effective option resectable MSI-H
Language: Английский
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Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217792 - 217792
Published: May 1, 2025
Language: Английский
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International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144477 - 144477
Published: May 1, 2025
Language: Английский
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