European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 284, P. 117212 - 117212
Published: Dec. 27, 2024
Language: Английский
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 97 - 97
Published: Jan. 3, 2025
mRNA technology can replace the expensive recombinant for every type of protein, making biological drugs more affordable. It also expedite entry new drugs, and copies approved products be treated as generic or biosimilar due to their chemical nature. The introduction hundreds protein have been blocked high cost development. low CAPEX OPEX associated with bring it within reach developing countries that are currently deprived life-saving drugs. In this paper, we advise developers introduce novel proteins switch manufacturing delivery, further regulatory authorities allow approval less testing. We anticipate will make such natural engineered proteins, monoclonal antibodies, vaccines, accessible billions patients worldwide.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 22, 2025
Despite the significant advancements in cancer research, innovative approaches are still needed to reduce tumor incidence, progression, and dissemination, as well for prolonging patient survival. Currently, development of vaccines is gaining attention a novel preventative therapeutic strategy. Although concept vaccination not new, limited number have received approval therapy. Heat shock protein (HSP)-based represents promising strategy that harnesses specific antigens activate immune responses. Exosomes (Exs) highly heterogeneous bilayer vesicles capable transporting various types molecules through extracellular space. Compared with conventional anticancer drugs, exosomes exhibit low toxicity good biocompatibility, they can stimulate system either directly or indirectly. Ex-based may elicit an antitumor response generates memory cells recognizing antigens, thereby inhibiting disease progression. This paper reviews potential applications HSPs prevention treatment solid tumors. Finally, we discuss advantages exosomal heat (HSP-Ex 1 ) vaccine future research directions aimed at optimizing protein-based immunotherapy strategies.
Language: Английский
Citations
0
Lung Cancer, Journal Year: 2025, Volume and Issue: 200, P. 108103 - 108103
Published: Jan. 23, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 25, 2025
Language: Английский
Citations
0
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217571 - 217571
Published: Feb. 1, 2025
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
HSP70 is a molecular chaperone that plays critical role in normal physiology of the cell and highly activated under pathological conditions such as cancer. It has been well established implicated breast cancer development progression. Highly linked to processes, proliferation, metastasis, drug resistance, driving anti-apoptotic pathways. In Luminal A subtype, stabilizes ESR1 (estrogen receptor 1) PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) pathways, supporting survival, while B its interaction with Cyclin D1 TP53 contributes treatment resistance. HER2 (+) triggers aggressive tumor growth by increasing human epidermal factor 2 (HER2) signaling via stabilizing protein. triple-negative (TNBC), it supports stem cell-like properties interacting neurogenic locus notch homolog protein 1 (NOTCH1) nuclear factor-kappa (NF-κB) suppressing The effect on cells (CSCs) an important limiting therapeutic response initiating potential metastasis. turn, inhibits apoptosis, preventing death through B-cell lymphoma (BCL-2) stabilization suppression caspase activity. This review aims provide integrative view biology addressing functions subtypes, interactions apoptosis.
Language: Английский
Citations
0
SAGE Open Medicine, Journal Year: 2025, Volume and Issue: 13
Published: March 1, 2025
Objective: The increasing demand for precision medicine has spurred molecular diagnostic investigations to emphasize the utility of miRNA as significant biomarkers. Recent studies have underscored miRNA’s role prognostic, diagnostic, and therapeutic biomarkers in managing monitoring multiple myeloma patients. This review aims present latest insights on potential circulating bortezomib-resistant myeloma. Methods: For this purpose, a comprehensive thematic literature from January 2014 August 2024 was conducted utilizing databases CINAHL, Pubmed, Google Scholar. Twenty pertinent were meticulously analyzed categorized into following sections: Bortezomib (BTZ) resistance myeloma, predictive miRNAs BTZ resistance, impact Results: Of note, eight identified (i.e., miR-744, miR-130a, let-7d, let-7e, miR-34a, etc.). In comparison, nine several that can be used prognostic miR-20a, miR-483-5p, mir-1246, let-7a, Moreover, five promising mir-15a, mir-92a, mir-19a, discovery significantly enhance early detection, accurate diagnosis, prognosis, overall survival rates, quality life patients with Conclusion: Based evidence, exploring noninvasive biomarker represents noteworthy advancement. is attributed abundance plasma or serum, which exhibits remarkable stability against enzymatic degradation.
Language: Английский
Citations
0
Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)
Published: Dec. 19, 2024
ABSTRACT In our previous study, Schiff base ( 1 ) complexes derived from 2,3‐diaminophenazine and metal ions Co(II) 2 ), Ni(II) 3 Cu(II) 4 Cd(II) 5 were synthesized characterized, demonstrating a significant biological activity. This study investigates their anticancer potential, specifically against prostate cancer. The exhibited notable reductions in cancer cell viability, with IC 50 values of 0.531 μM Ni(II), 0.630 Cu(II), 0.655 Co(II), comparable the standard drug enzalutamide. complex showed highest efficacy, while displayed lowest (IC = 0.648 μM). presence phenazine ring these enhances DNA binding, contributing to effects. HOMO‐LUMO calculations revealed energy gaps ranging 2.525 3.294 eV, indicating varying reactivity potential for interactions. Molecular docking studies that compound binding affinity (−9.19 kcal/mol) cancer‐related receptor, hydrogen bond dynamics simulations over 100 ns demonstrated stable RMSD below 1.5 Å, RMSF analysis provided insights into protein flexibility. ADMET favorable drug‐like properties, including good gastrointestinal absorption (> 30%), high blood–brain barrier permeability (LogBBB 0.64), human intestinal (68.47%–88.79%). No inhibition CYP2D6 was observed, suggesting low risk drug–drug These base‐metal show promising activity profiles, as therapeutic agents treatment.
Language: Английский
Citations
3
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Abstract The cellular stress response (CSR) is a conserved mechanism that protects cells from environmental and physiological stressors. heat shock (HSR), critical component of the CSR, utilizes molecular chaperones to mitigate proteotoxic caused by elevated temperatures. We hypothesized while canonical HSR pathways are across cell types, specific lines may exhibit unique transcriptional responses shock. To test this, we compared transcriptomic HEK293, HepG2, HeLa under control conditions immediately following after an 8-hour recovery period. RNA sequencing revealed activation pathways, including unfolded protein response, alongside enrichment non-canonical “Receptor Ligand Activity” pathway all lines. Cell line-specific variations were also observed, with HepG2 displaying more uniquely expressed genes expression levels (fold changes) shared conditions. Validation qPCR confirmed key within time points. These findings provide insights into context-specific aspects HSR, contributing comprehensive understanding mechanisms mammalian cells.
Language: Английский
Citations
0
European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 284, P. 117212 - 117212
Published: Dec. 27, 2024
Language: Английский
Citations
0