Biology Direct,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Jan. 11, 2023
Pancreatic
cancer
(PC)
is
a
highly
lethal
malignancy
that
requires
effective
novel
therapies.
M2
macrophages
are
abundant
in
the
PC
microenvironment
and
promote
progression.
Exosomes
emerging
mediators
of
crosstalk
between
cells
microenvironment.
This
study
was
conducted
to
explore
role
macrophage-derived
exosomes
PC.Exosomes
derived
from
were
extracted.
miR-193b-3p
TRIM62
overexpressed
or
silenced
examine
their
function
PC.
Luminescence
assays
used
investigate
interaction
TRIM62.
Cell
proliferation
examined
by
EdU
staining.
Would
healing
transwell
applied
evaluate
cell
migration
invasion.
Co-immunoprecipitation
assess
c-Myc.
Gene
protein
expressions
analyzed
quantitative
RT-PCR
immunoblotting,
respectively.M2
exosomal
promoted
proliferation,
migration,
invasion,
glutamine
uptake
SW1990
cells.
Mechanism
revealed
target
miR-193b-3p.
inhibited
promoting
c-Myc
ubiquitination.
Our
data
also
suggested
expression
negatively
correlated
with
expression.
High-expression
predicts
poor
prognosis,
whereas
low-expression
prognosis
patients
PC.M2
enhances
targeting
TRIM62,
resulting
decrease
not
only
reveals
mechanism
underlying
but
suggests
promising
therapeutic
for
Molecules,
Journal Year:
2022,
Volume and Issue:
27(15), P. 4750 - 4750
Published: July 25, 2022
Cancer
is
one
of
the
world’s
most
burdensome
diseases,
with
increasing
prevalence
and
a
high
mortality
rate
threat.
Tumor
recurrence
metastasis
due
to
treatment
resistance
are
two
primary
reasons
that
cancers
have
been
so
difficult
treat.
The
epithelial–mesenchymal
transition
(EMT)
essential
for
tumor
drug
resistance.
EMT
causes
cells
produce
mesenchymal
stem
quickly
adapt
various
injuries,
showing
treatment-resistant
phenotype.
In
addition,
multiple
signaling
pathways
regulatory
mechanisms
involved
in
EMT,
resulting
hard
eradication
tumors.
purpose
this
study
review
link
between
therapeutic
resistance,
molecular
process,
offer
theoretical
framework
EMT-based
tumor-sensitization
therapy.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2023,
Volume and Issue:
42(1)
Published: March 10, 2023
Metabolic
reprogramming
is
one
of
the
hallmarks
cancer.
As
nutrients
are
scarce
in
tumor
microenvironment
(TME),
cells
adopt
multiple
metabolic
adaptations
to
meet
their
growth
requirements.
not
only
present
cells,
but
exosomal
cargos
mediates
intercellular
communication
between
and
non-tumor
TME,
inducing
remodeling
create
an
outpost
microvascular
enrichment
immune
escape.
Here,
we
highlight
composition
characteristics
meanwhile
summarize
components
corresponding
sorting
mode.
Functionally,
these
cargos-mediated
improves
"soil"
for
metastasis.
Moreover,
discuss
abnormal
metabolism
targeted
by
its
potential
antitumor
therapy.
In
conclusion,
this
review
updates
current
role
TME
enriches
future
application
scenarios
exosomes.
Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1586 - 1586
Published: Nov. 9, 2023
The
discovery
of
therapeutic
miRNAs
is
one
the
most
exciting
challenges
for
pharmaceutical
companies.
Since
first
miRNA
was
discovered
in
1993,
our
knowledge
biology
has
grown
considerably.
Many
studies
have
demonstrated
that
expression
dysregulated
many
diseases,
making
them
appealing
tools
novel
approaches.
This
review
aims
to
discuss
biogenesis
and
function,
as
well
highlight
strategies
delivering
agents,
presenting
viral,
non-viral,
exosomic
delivery
approaches
different
cancer
types.
We
also
consider
role
microRNA-mediated
drug
repurposing
therapy.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Nov. 30, 2023
Current
research
has
demonstrated
that
extracellular
vesicles
(EVs)
and
circulating
tumor
cells
(CTCs)
are
very
closely
related
in
the
process
of
distant
metastasis.
Primary
tumors
shed
released
into
bloodstream
to
form
CTCs
referred
as
seeds
colonize
grow
soil-like
target
organs,
while
EVs
nontumor
origin
act
fertilizers
There
is
no
previous
text
provides
a
comprehensive
review
role
on
during
In
this
paper,
we
reviewed
mechanisms
metastasis,
including
ability
enhance
shedding
CTCs,
protect
circulation
determine
direction
CTC
thus
affecting
metastasis
tumors.
Biology Direct,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Jan. 11, 2023
Pancreatic
cancer
(PC)
is
a
highly
lethal
malignancy
that
requires
effective
novel
therapies.
M2
macrophages
are
abundant
in
the
PC
microenvironment
and
promote
progression.
Exosomes
emerging
mediators
of
crosstalk
between
cells
microenvironment.
This
study
was
conducted
to
explore
role
macrophage-derived
exosomes
PC.Exosomes
derived
from
were
extracted.
miR-193b-3p
TRIM62
overexpressed
or
silenced
examine
their
function
PC.
Luminescence
assays
used
investigate
interaction
TRIM62.
Cell
proliferation
examined
by
EdU
staining.
Would
healing
transwell
applied
evaluate
cell
migration
invasion.
Co-immunoprecipitation
assess
c-Myc.
Gene
protein
expressions
analyzed
quantitative
RT-PCR
immunoblotting,
respectively.M2
exosomal
promoted
proliferation,
migration,
invasion,
glutamine
uptake
SW1990
cells.
Mechanism
revealed
target
miR-193b-3p.
inhibited
promoting
c-Myc
ubiquitination.
Our
data
also
suggested
expression
negatively
correlated
with
expression.
High-expression
predicts
poor
prognosis,
whereas
low-expression
prognosis
patients
PC.M2
enhances
targeting
TRIM62,
resulting
decrease
not
only
reveals
mechanism
underlying
but
suggests
promising
therapeutic
for
