HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137 DOI Creative Commons
Karly Nisson,

Rishi S Patel,

Yennifer Delgado

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

ABSTRACT The lentiviral accessory protein Vpr engages an extensive network of cellular pathways to drive diverse host consequences. Of its many phenotypes, CRL4A-E3 ubiquitin ligase complex co-option, DNA damage response (DDR) engagement, and G2/M arrest are conserved thus proposed be functionally important. How effects these functions whether they explain how dysregulates additional remain unclear. Here we leverage the ability deplete nucleolar CCDC137 understand Vpr-induced DDR activation impacts processes. We characterize as indirect target whose degradation does not correlate with arrest. Yet, is among from pandemic HIV-1 related SIVcpz/SIVgor, it triggered by genomic insults that activate a ATR pathway in manner similar camptothecin. determine causes ATR-dependent features stress degradation, including redistribution proteins, altered morphology, repressed ribosome biogenesis. Together, this data distinguishes non-canonical may serve sensor disruption, doing so, identifies novel role for stress. GRAPHICAL

Language: Английский

MVP-LCN2 axis triggers evasion of ferroptosis to drive hepatocarcinogenesis and sorafenib resistance DOI
Jiawen Xu, Bo Wang, Qiaoyu Liu

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101246 - 101246

Published: April 17, 2025

Language: Английский

Citations

1
Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity DOI Open Access
Anitha Vijayakumar,

Sekar Vasudevan,

Samu John

et al.

Immunometabolism, Journal Year: 2025, Volume and Issue: 7(1), P. e00054 - e00054

Published: Jan. 1, 2025

The oral epithelium, a dynamic interface constantly facing environmental challenges, relies on intricate molecular pathways to maintain its homeostasis. This comprehensive review delves into the nuanced interplay between T-lymphocytic cells (T cells) and RNA-binding proteins (RBPs) within elucidating their roles in orchestrating immune responses influencing tissue plasticity. By synthesizing current knowledge, we aim unravel intricacies that govern this interplay, with focus potential therapeutic implications for health diseases. Understanding regulatory networks shaped by T RBPs epithelial microenvironment holds promise innovative strategies managing conditions associated dysfunction.

Language: Английский

Citations

0
Exploring RNA binding proteins in hepatocellular carcinoma: insights into mechanisms and therapeutic potential DOI Creative Commons

Xing Ren,

Wen-Na Yang,

Xiuli Yan

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: April 24, 2025

Abstract Hepatocellular carcinoma (HCC), the most prevalent type of primary liver cancer, is linked to elevated global incidence and mortality rates. Elucidating intricate molecular pathways that drive progression HCC imperative for devising targeted effective therapeutic interventions. RNA-binding proteins (RBPs) serve as pivotal regulators post-transcriptional processes, influencing various cellular functions. This review endeavors provide a comprehensive analysis expression, function, potential implications RBPs in HCC. We discuss classification diverse roles RBPs, with particular focus on key implicated their association disease progression. Additionally, we explore mechanisms by which contribute HCC, including impact gene cell proliferation, metastasis, angiogenesis, signaling pathways, modifications. Importantly, examine targets prognostic biomarkers, offering insights into relevance treatment. Finally, outline future research directions, emphasizing need further investigation functional clinical translation personalized therapy. highlights role novel avenues improve patient outcomes. Graphical

Language: Английский

Citations

0
The oncogenic role of FOXM1 in hepatocellular carcinoma: molecular mechanisms, clinical significance, and therapeutic potentials DOI
Fengtian He, He Liu, Fangcheng Zhao

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0
Revealing the hidden RBP–RNA interactions with RNA modification enzyme‐based strategies DOI Creative Commons
Hua Jin, Chong Li,

Yunxiao Jia

et al.

Wiley Interdisciplinary Reviews - RNA, Journal Year: 2024, Volume and Issue: 15(3)

Published: May 1, 2024

RNA-binding proteins (RBPs) are powerful and versatile regulators in living creatures, playing fundamental roles organismal development, metabolism, various diseases by the regulation of gene expression at multiple levels. The requirements deep research on RBP function have promoted rapid development RBP-RNA interplay detection methods. Recently, method fusing RNA modification enzymes (RME) with interest has become a hot topic. Here, we reviewed adenosine deaminases that act (ADAR), terminal nucleotidyl transferase (TENT), activation-induced cytosine deaminase/ApoB mRNA editing enzyme catalytic polypeptide-like (AID/APOBEC) protein family, regarding biological function, biochemical activity, substrate specificity originated from selves, their domains partner proteins. In addition, discussed RME activity screening system, mutations engineered activity. Furthermore, provided systematic overview basic principles, advantages, disadvantages, applications RME-based cross-linking immunopurification (CLIP)-based target profiling strategies, including targets identified (TRIBE), tagging, surveying APOBEC-mediated (STAMP), CLIP-seq, derivative technology. This article is categorized under: Interactions Proteins Other Molecules > Protein-RNA Recognition Processing Editing Modification.

Language: Английский

Citations

2
CRISPR/Cas13 sgRNA‐Mediated RNA–RNA Interaction Mapping in Live Cells with APOBEC RNA Editing DOI Creative Commons
Li‐Ting Diao, Shu‐Juan Xie,

Wan‐Yi Xu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(45)

Published: Oct. 11, 2024

Abstract Current research on long non‐coding RNA (lncRNA) has predominantly focused identifying their protein partners and genomic binding sites, leaving largely unknown. To address this gap, the study developed a method called sarID (sgRNA scaffold assisted RNA‐RNA interaction detection), which integrates Cas13‐based targeting, sgRNA engineering, proximity editing to investigate lncRNA‐RNA interactomes. By applying lncRNA NEAT1 , over one thousand previously unidentified transcripts are discovered. is further expanded binders of XIST MALAT1, NBR2 DANCR demonstrating its broad applicability in interactions. The findings suggest that lncRNAs may regulate gene expression by interacting with mRNAs, expanding roles beyond known functions as scaffolds, miRNA sponges, or guides for epigenetic modulators. potential be adapted studying other specific RNAs, providing novel immunoprecipitation‐free uncovering facilitating exploration interactome.

Language: Английский

Citations

2
MicroRNAs and RNA-Binding Protein-Based Regulation of Bone Metastasis from Hepatobiliary Cancers and Potential Therapeutic Strategies DOI Creative Commons
Sharmila Fagoonee, Ralf Weiskirchen

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1935 - 1935

Published: Nov. 21, 2024

Hepatobiliary cancers, such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the deadliest malignancies worldwide, leading to a significant number of cancer-related deaths. While bone metastases from these cancers rare, they highly aggressive linked poor prognosis. This review focuses on RNA-based molecular mechanisms that contribute metastasis hepatobiliary cancers. Specifically, role two key factors, microRNAs (miRNAs) RNA-binding proteins (RBPs), which have not been extensively studied in context HCC CCA, is discussed. These molecules often exhibit abnormal expression tumors, influencing cancer cell spread by disrupting homeostasis, thereby aiding tumor migration survival microenvironment. also discusses potential therapeutic strategies targeting pathways reduce improve patient outcomes. Further research crucial for developing effective miRNA- RBP-based diagnostic prognostic biomarkers treatments prevent

Language: Английский

Citations

2
Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT DOI

Lei Xu,

Qiumeng Liu,

Hailing Liu

et al.

Cell Death and Differentiation, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Language: Английский

Citations

1
IGF2BP3 regulates macrophage-induced inflammation and liver damage in acute-on-chronic liver failure via the RORα-NF-κB signaling axis DOI
K.Y. Cheng,

Kai Liu,

Shu Liu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113030 - 113030

Published: Sept. 3, 2024

Language: Английский

Citations

1
PPIH as a poor prognostic factor increases cell proliferation and m6A RNA methylation in hepatocellular carcinoma DOI

Xiaoxia Chi,

Peng Ye,

Nengqi Cao

et al.

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(8), P. 3733 - 3756

Published: Jan. 1, 2024

RNA-binding proteins (RBPs) play a crucial role in the biological processes of liver hepatocellular carcinoma (LIHC). Peptidyl-prolyl cis-trans isomerase H (PPIH), an RBP, possesses prolyl activity and functions as protein chaperone. The relationship between PPIH LIHC has not yet been fully elucidated. This study elucidated potential mechanisms through which affects prognosis LIHC. Bioinformatics analysis vitro experiments revealed that expression was higher tissues than normal tissues. identified independent prognostic factor, with high being associated worse prognoses. Moreover, increased m6A RNA methylation level promoted cell proliferation by modulating DNA replication cycle-related genes cells. also immune infiltration checkpoint proteins. Collectively, these findings indicate might promote progression enhancing level, increasing proliferation, altering tumor microenvironment. Our demonstrates PPIH, poor may lead to malignancy multiple pathways. Further in-depth research on this topic is warranted.

Language: Английский

Citations

0