Cancer Informatics,
Journal Year:
2024,
Volume and Issue:
23
Published: Jan. 1, 2024
Objectives:
Emerging
evidence
suggests
that
N6-methyladenosine
(m
6
A)
methylation
plays
a
critical
role
in
cancers
through
various
mechanisms.
This
work
aims
to
reveal
the
essential
of
m
A
“readers”
regulation
cancer
prognosis
at
pan-cancer
level.
Methods:
Herein,
we
focused
on
one
special
protein
family
methylation,
YT521-B
homology
(YTH)
domain
genes,
which
were
observed
be
frequently
dysregulated
tumor
tissues
and
closely
associated
with
prognosis.
Then,
comprehensive
analysis
modulation
was
conducted
by
integrating
RNA
sequencing
(RNAseq)
datasets
YTH
genes
clinical
information
Results:
significantly
differentially
expressed
most
cancers,
particularly
increased
Gastrointestinal
decreased
Endocrine
Urologic
cancers.
In
addition,
they
overall
survival
(OS)
disease-specific
(DSS)
extent,
especially
lower
grade
glioma
(LGG),
thyroid
(THCA),
liver
hepatocellular
carcinoma
(LIHC)
kidney
clear
cell
(KIRC),
so
some
“writers”
(METLL3,
METLL14,
WTAP)
“erasers”
(FTO,
ALKBH5).
Further
illustrated
specifically
YTHScore
constructed
combining
5
as
well
RWEScore
calculated
from
“readers”-“writers”-“erasers”
could
dramatically
distinguish
4
representative
As
expected,
presented
an
equally
comparable
prognostic
classification
RWEScore.
Finally,
immune
signatures
characteristics
implied
that,
activity
innate
immune,
diagnostic
age,
stage,
Tumor-Node-Metastasis
(TNM)
stage
types,
might
play
specific
roles
modulating
Conclusions:
The
study
demonstrated
had
potential
predict
prognosis,
equal
ability
compared
RWEScore,
thus
providing
insights
into
biomarkers
therapeutic
targets
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Ferroptosis
is
a
nonapoptotic
form
of
cell
death
discovered
in
2012.
Noninvasive
treatments
regulating
ferroptosis
are
important
for
wide
range
diseases.
Among
the
noninvasive
treatments,
sonodynamic
therapy
(SDT)
has
become
promising
due
to
its
strong
tissue
penetration
and
few
side
effects.
In
recent
years,
targeted
drug
delivery
platforms
constructed
on
basis
SDT
have
provided
an
efficient
mode
regulation
ferroptosis.
Based
latest
research
reports,
this
Perspective
introduces
basic
mechanism
influencing
factors
therapeutic
effects,
elucidates
significance
ferroptosis-targeted
SDT,
summarizes
studies
through
different
pathways.
We
also
present
innovative
composite
ultrasound-responsive
platforms.
Finally,
brief
summary
outlook
based
current
presented.
European journal of medical research,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: April 7, 2025
Inflammatory
bowel
disease
(IBD)
includes
chronic
inflammatory
conditions,
such
as
Crohn's
and
ulcerative
colitis,
characterized
by
impaired
function
of
the
intestinal
mucosal
epithelial
barrier.
In
recent
years,
ferroptosis,
a
novel
form
cell
death,
has
been
confirmed
to
be
involved
in
pathological
process
IBD
is
related
various
changes,
oxidative
stress
inflammation.
Recent
studies
have
further
revealed
complex
interactions
between
microbiome
indicating
that
ferroptosis
an
important
target
for
regulation
gut
microbiota
its
metabolites.
This
article
reviews
significant
roles
microbial
metabolites,
short-chain
fatty
acids,
tryptophan,
bile
IBD.
These
metabolites
participate
influencing
microenvironment,
modulating
immune
responses,
altering
levels,
thereby
exerting
impact
on
development
Treatments
based
are
gradually
becoming
research
hotspot.
Finally,
we
discuss
potential
current
therapeutic
approaches,
including
antibiotics,
probiotics,
prebiotics,
fecal
transplantation,
microbiota,
affecting
improving
symptoms.
With
deeper
understanding
interaction
mechanisms
it
expected
more
precise
effective
treatment
strategies
will
developed
future.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 9, 2025
The
most
common
form
of
internal
RNA
modification
in
eukaryotes
is
called
n6-methyladenosine
(m6A)
methylation.
It
has
become
more
and
well-known
as
a
research
issue
recent
years
since
it
alters
metabolism
involved
numerous
biological
processes.
Currently,
m6A
alteration
offers
new
opportunities
clinical
applications
intimately
linked
to
carcinogenesis.
Ferroptosis-a
iron-dependent,
lipid
peroxidation-induced
regulated
cell
death-was
discovered.
In
the
development
cancer,
an
important
factor.
According
newly
available
data,
ferroptosis
regulates
tumor
growth,
cancer
exhibits
aberrant
levels
crucial
regulatory
components.
On
other
hand,
multiple
roles
tumors,
relationship
between
m6A-modified
malignancies
quite
intricate.
this
review,
we
first
give
thorough
review
functional
methylation,
focusing
on
molecular
processes
through
regulation
human
progression
metastasis,
which
are
strongly
associated
initiation,
progression,
drug
resistance.
Therefore,
clarify
m6A-mediated
providing
strategy
for
treatment
with
substantial
implications.
BMC Cardiovascular Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 18, 2025
Myocardial
infarction
(MI)
is
a
leading
cause
of
global
mortality.
Ferroptosis,
an
iron-dependent
form
programmed
cell
death,
has
recently
emerged
as
critical
player
in
cardiovascular
diseases.
N6-methyladenosine
(m6A),
the
most
prevalent
RNA
methylation
modification
eukaryotic
cells,
been
implicated
various
pathological
processes;
however,
its
regulatory
role
MI
through
ferroptosis
remains
poorly
understood.
This
study
aimed
to
elucidate
mechanism
by
which
m6A
mediates
via
ferroptosis.
A
hypoxia/reoxygenation
(H/R)
model
was
established
using
H9C2
cells
simulate
myocardial
injury.
levels
were
quantified
dot
blot
assay.
Ferroptosis
evaluated
measuring
lactate
dehydrogenase
(LDH)
release,
Fe2+
levels,
glutathione
(GSH),
lipid
reactive
oxygen
species
(ROS),
malondialdehyde
(MDA),
and
apoptosis.
The
underlying
molecular
mechanisms
investigated
western
blotting,
quantitative
real-time
PCR
(qPCR),
methylated
immunoprecipitation
(MeRIP),
RIP.
Findings
further
validated
ischemia/reperfusion
injury
(MIRI)
rat
model.
results
revealed
that
significantly
elevated
H/R
model,
accompanied
reduced
expression
Alkbh5
mRNA.
Moreover,
overexpression
inhibited
increased
Mechanistically,
decreased
Ythdf1
while
promoting
Fth1
translation
enhancing
mRNA
expression.
Knockdown
restored
counteracting
effects
overexpression.
Furthermore,
alleviated
MIRI
upregulated
expression,
protein
levels.
demonstrates
ameliorates
inhibiting
demethylation
Fth1.
These
findings
provide
novel
insights
into
highlight
potential
therapeutic
targets
for
treatment.
Cancer Informatics,
Journal Year:
2024,
Volume and Issue:
23
Published: Jan. 1, 2024
Objectives:
Emerging
evidence
suggests
that
N6-methyladenosine
(m
6
A)
methylation
plays
a
critical
role
in
cancers
through
various
mechanisms.
This
work
aims
to
reveal
the
essential
of
m
A
“readers”
regulation
cancer
prognosis
at
pan-cancer
level.
Methods:
Herein,
we
focused
on
one
special
protein
family
methylation,
YT521-B
homology
(YTH)
domain
genes,
which
were
observed
be
frequently
dysregulated
tumor
tissues
and
closely
associated
with
prognosis.
Then,
comprehensive
analysis
modulation
was
conducted
by
integrating
RNA
sequencing
(RNAseq)
datasets
YTH
genes
clinical
information
Results:
significantly
differentially
expressed
most
cancers,
particularly
increased
Gastrointestinal
decreased
Endocrine
Urologic
cancers.
In
addition,
they
overall
survival
(OS)
disease-specific
(DSS)
extent,
especially
lower
grade
glioma
(LGG),
thyroid
(THCA),
liver
hepatocellular
carcinoma
(LIHC)
kidney
clear
cell
(KIRC),
so
some
“writers”
(METLL3,
METLL14,
WTAP)
“erasers”
(FTO,
ALKBH5).
Further
illustrated
specifically
YTHScore
constructed
combining
5
as
well
RWEScore
calculated
from
“readers”-“writers”-“erasers”
could
dramatically
distinguish
4
representative
As
expected,
presented
an
equally
comparable
prognostic
classification
RWEScore.
Finally,
immune
signatures
characteristics
implied
that,
activity
innate
immune,
diagnostic
age,
stage,
Tumor-Node-Metastasis
(TNM)
stage
types,
might
play
specific
roles
modulating
Conclusions:
The
study
demonstrated
had
potential
predict
prognosis,
equal
ability
compared
RWEScore,
thus
providing
insights
into
biomarkers
therapeutic
targets
