Prediction of circRNA-drug sensitivity using random auto-encoders and multi-layer heterogeneous graph transformers DOI
Yinbo Liu, Xinxin Ren, Jun Li

et al.

Applied Intelligence, Journal Year: 2024, Volume and Issue: 55(4)

Published: Dec. 30, 2024

Language: Английский

CircRNA and lncRNA-encoded peptide in diseases, an update review DOI Creative Commons
Qian Yi,

Jianguo Feng,

Weiwu Lan

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 30, 2024

Language: Английский

Citations

11
Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities DOI Creative Commons
Junshu Li, Wencheng Zhou, Huiling Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 24, 2024

Exosomes can regulate the malignant progression of tumors by carrying a variety genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, immune escape. In microenvironment (TME), circRNAs be transferred among cells, endothelial cancer-associated fibroblasts, microbiota, affecting initiation progression. Due high stability widespread presence circRNAs, they hold promise biomarkers for diagnosis prognosis prediction blood urine. addition, designing nanoparticles targeting utilizing derived from cells or stem provide new strategies cancer therapy. this review, we examined crucial role regulating tumor-related signaling pathways summarized transmission between various types their impact on TME. Finally, our review highlights potential diagnostic prognostic biomarkers, well suggesting clinical

Language: Английский

Citations

4
Paeonol enhances a recombinant EGFR-targeted fusion protein-drug conjugate induced antitumor efficacy in esophageal cancer DOI
Huaiyu Duan, Yuting Li, Xue Zheng

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 236, P. 116856 - 116856

Published: March 5, 2025

Language: Английский

Citations

0
Small open reading frame-encoded microproteins in cancer: identification, biological functions and clinical significance DOI Creative Commons

Tingting Zhang,

Zhang Li, Jiao Li

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 2, 2025

The human genome harbors approximately twenty thousand protein-coding genes, and a significant portion of life science research focuses on elucidating their functions the underlying mechanisms. Recent studies have revealed that small open reading frame (sORF), originating from non-coding RNAs or 5' leader sequences messenger RNAs, can be translated into peptides called microproteins through cap-dependent cap-independent These interact with diverse molecular partners to modulate gene expression at multiple regulatory levels, thereby playing critical roles in various biological processes. Notably, sORF-encoded exhibit aberrant patterns cancer are implicated tumor initiation progression, expanding our understanding biology. In this review, we introduce translational mechanisms identification methods microproteins, summarize dysregulation regulating expression, emphasize driving hallmark events cancer. Furthermore, discuss clinical significance as diagnostic prognostic biomarkers, well therapeutic targets.

Language: Английский

Citations

0
Circ_0096710 facilitates tumor growth via controlling ADAM10 expression in esophageal squamous cell carcinoma DOI Creative Commons
Chaoqun Dong, Zhilong Li

Thoracic Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Background Esophageal squamous cell carcinoma (ESCC) is a global cancer related to the sixth largest cause of death. Circular RNAs (circRNAs) have affected progress ESCC during recent years, but mechanism not completely clear. So here we probed effects hsa_circ_0096710 (circ_0096710) in ESCC. Methods Relative levels circ_0096710, miR‐1294, and ADAM10 were quantified by quantitative real‐time reverse transcription‐polymerase chain reaction tissues. Western blot assessed ADAM10, PCNA, MMP2, VEGFA, OCT4 protein levels. Cell proliferative capacity was counting colony‐forming assays. Transwell assays migration invasion. Angiogenesis detected tube formation Stemness cells estimated sphere Dual‐luciferin reporter RNA immunoprecipitation determined targeting relationship between miR‐1294 circ_0096710 or ADAM10. Results mRNA upregulated cells, yet downregulated. Circ_0096710 silencing repressed proliferation, migration, invasion, angiogenesis, stem‐like properties. Moreover, an upstream target inhibition reversed role downregulation cells. Furthermore, downstream overexpression suppressed properties Meanwhile, upgraded expression through sponging miR‐1294. Also, restrained tumor growth mouse models. Conclusion upregulates via mediating so as accelerate occurrence ESCC, suggesting that may be potential therapeutic for

Language: Английский

Citations

0
USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer DOI Creative Commons
Fang Yuan, Juan Xu, Xuan Liu

et al.

Neoplasia, Journal Year: 2024, Volume and Issue: 60, P. 101101 - 101101

Published: Dec. 14, 2024

Language: Английский

Citations

0
Prediction of circRNA-drug sensitivity using random auto-encoders and multi-layer heterogeneous graph transformers DOI
Yinbo Liu, Xinxin Ren, Jun Li

et al.

Applied Intelligence, Journal Year: 2024, Volume and Issue: 55(4)

Published: Dec. 30, 2024

Language: Английский

Citations

0