Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles DOI Creative Commons

Javier Huete-Acevedo,

Cristina Mas‐Bargues,

Marta Arnal-Forné

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1493 - 1493

Published: Dec. 6, 2024

Extracellular vesicles (EVs) are small, membrane-bound particles secreted by cells into the extracellular environment, playing an increasingly recognized role in inter-organ communication and regulation of various physiological processes. Regarding redox homeostasis context, EVs play a pivotal propagating mitigating oxidative stress signals across different organs. Cells under release containing signaling molecules that can influence status distant tissues. starting to be as contributors brain-liver communication. Therefore, this review, we show how imbalance affect brain liver. We propose mediators axis.

Language: Английский

The uptake of extracellular vesicles: research progress in cancer drug resistance and beyond DOI

Luomeng Qian,

Pangzhou Chen,

Shiwu Zhang

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 79, P. 101209 - 101209

Published: Feb. 1, 2025

Language: Английский

Citations

1
Combination of ionizing radiation and 2-thio-6-azauridine induces cell death in radioresistant triple negative breast cancer cells by downregulating CD151 expression DOI

Rakshmitha Marni,

Manas Malla, Anindita Chakraborty

et al.

Cancer Chemotherapy and Pharmacology, Journal Year: 2024, Volume and Issue: 94(5), P. 685 - 706

Published: Aug. 21, 2024

Language: Английский

Citations

5
Migrasome-related prognostic signature TSPAN4 correlates with immune infiltrates and metabolic disturbances in hepatocellular carcinoma DOI
Xiaoli Zhang, ­Jun Li­,

Yichen Yao

et al.

Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Language: Английский

Citations

0
The controversial role of CD151 in different solid tumors: promoter or suppressor? DOI Creative Commons
Xueqin Gao, Sa Liu,

Yubo Cao

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 21, 2025

As a member of the tetraspanin superfamily, CD151 plays pivotal role in tumorigenesis, progression, and metastasis. is involved various cellular processes, including cell-cell junction, signal transduction, epithelial-mesenchymal transition (EMT), cancer stem cell maintenance (CSCs), angiogenesis, exosome regulation. Therefore, potential target for tumor therapy may be valuable diagnosis prognosis. Notably, while predominantly functions as an oncogene most cancers, it can also exhibit tumor-suppressive roles specific contexts, indicating that its function context-dependent. Additionally, significant modulating immune microenvironment. For instance, supports proliferation, activation, migration T cells. The peptide vaccination by stimulating CD8 + IFNγ lymphocytes inducing cytotoxic effects. Thus, tumors intricate warrants further investigation. In this review, we discuss diagnostic prognostic CD151, well regulatory solid those digestive system, lung, breast, prostate, gynecological tissues. Basic experiments clinical data demonstrate beneficial detrimental effects malignancies offer path forward future Tetraspanins transmembrane four superfamily protein, participates activities, transition, maintenance, Interestingly, primarily acts promoter certain contexts. Here, explore dual tumors, tract, lungs, tissue, potential.

Language: Английский

Citations

0
Migrasome Marker Epidermal Growth Factor Domain-Specific O-GlcNAc Transferase: Pan-Cancer Angiogenesis Biomarker and the Potential Role of circ_0058189/miR-130a-3p/EOGT Axis in Hepatocellular Carcinoma Progression and Sorafenib Resistance DOI Creative Commons
Zhe Yu,

Jing Luo,

Wen An

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 773 - 773

Published: March 22, 2025

Background: The EGF domain-specific O-GlcNAc transferase (EOGT), a migrasome marker, plays emerging roles in cancer biology through O-GlcNAcylation modifications, yet its pan-cancer functions and therapeutic implications remain underexplored. This study aimed to systematically characterize EOGT’s oncogenic mechanisms across malignancies, with particular focus on hepatocellular carcinoma (HCC) progression sorafenib resistance. Methods: Multi-omics analysis integrated TCGA/GTEx data from 33 types spatial/single-cell transcriptomics 10 HCC cohorts. Functional validation employed Huh7 cell models EOGT modulation, RNA sequencing, ceRNA network construction. Drug sensitivity leveraged GDSC/CTRP/PRISM databases, while immune microenvironment assessment utilized ESTIMATE/TIMER algorithms. Results: showed cancer-specific dysregulation, marked by significant upregulation correlating advanced stages poor survival. Pan-cancer revealed association genomic instability, tumor stemness, angiogenesis. Experimental demonstrated promotion of proliferation migration. A novel exosomal circ_0058189/miR-130a-3p/EOGT axis was identified, showing that circ_0058189 upregulated tissues, plasma samples exosomes sorafenib-resistant cells. Conclusion: establishes as angiogenesis biomarker, elucidating role resistance via circRNA-mediated regulation, providing mechanistic insights for targeted intervention strategies.

Language: Английский

Citations

0
Migrasomes, critical players in intercellular communication DOI Creative Commons
Zhiyong Tan,

Chadanfeng Yang,

Shihui Fu

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 25, 2025

Migrasomes are a newly discovered type of extracellular vesicle (EV) formed during cell migration, playing pivotal role in intercellular communication. These vesicles generated by retracting fibers migrating cells and encapsulate various molecules, such as proteins, lipids, RNA, allowing the transfer biochemical signals to neighboring cells. Current evidence suggests that migrasomes involved wide range physiological processes embryogenesis, angiogenesis, immune modulation, mitochondrial quality control. Moreover, implicated pathological conditions, including cancer metastasis, cardiovascular diseases, viral infections. To fully understand their significance, it is critical first explore molecular mechanisms underlying formation function. Recent studies have shed light on biogenesis, release, biological properties migrasomes, all which key understanding cell-to-cell In this review, we provide an up-to-date summary migrasome characterization, activities communication, while also proposing potential new functions for these vesicles.

Language: Английский

Citations

0
Migrasomes: Critical players in intercellular nanovesicle communication DOI
Jiayu Zhang, Shangeng Weng, Fan Zhang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111796 - 111796

Published: April 1, 2025

Language: Английский

Citations

0
Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases DOI Creative Commons
Qingfu Zhang,

Jianyao Su,

Zhichao Li

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 20, 2025

Migrasomes are newly identified organelles that were first discovered in 2015. Since then, their biological structure, formation process, and physiological functions have been gradually elucidated. Research recent years has expanded our understanding of these aspects, highlighting significance various pathological processes. found to play crucial roles normal functions, including embryonic development, vascular homeostasis, material transport, mitochondrial quality control. Additionally, emerging evidence suggests involvement diseases; however, clinical research on remains limited. Current studies indicate migrasomes may contribute disease pathogenesis hold potential for diagnostic therapeutic applications. This review consolidates existing migrasomes, focusing role mechanisms use medical By examining structure function, this aims generate insights encourage further research, ultimately contributing advancements prevention treatment.

Language: Английский

Citations

0
A novel prognostic model based on migrasome-related LncRNAs for gastric cancer DOI Creative Commons
Wenhao Jiang,

Jiaying Shi,

Yingchuan Zhu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 25, 2025

Language: Английский

Citations

0
Migrasomes: Emerging organelles for unveiling physiopathology and advancing clinical implications DOI

Janet Mei,

Xiaoli Cao, Bo Zhou

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123152 - 123152

Published: Oct. 1, 2024

Language: Английский

Citations

1