Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles DOI Creative Commons

Javier Huete-Acevedo,

Cristina Mas‐Bargues,

Marta Arnal-Forné

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1493 - 1493

Published: Dec. 6, 2024

Extracellular vesicles (EVs) are small, membrane-bound particles secreted by cells into the extracellular environment, playing an increasingly recognized role in inter-organ communication and regulation of various physiological processes. Regarding redox homeostasis context, EVs play a pivotal propagating mitigating oxidative stress signals across different organs. Cells under release containing signaling molecules that can influence status distant tissues. starting to be as contributors brain-liver communication. Therefore, this review, we show how imbalance affect brain liver. We propose mediators axis.

Language: Английский

Tetraspanins in digestive‑system cancers: Expression, function and therapeutic potential (Review) DOI Creative Commons
Kexin Chen, Qiuhong Li,

Yangyi Li

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(5)

Published: Sept. 6, 2024

The tetraspanin family of membrane proteins is essential for controlling different biological processes such as cell migration, penetration, adhesion, growth, apoptosis, angiogenesis and metastasis. present review summarized the current knowledge regarding expression roles tetraspanins in types cancer digestive system, including gastric, liver, colorectal, pancreatic, esophageal oral cancer. Depending on type context cancer, can act either tumor promoters or suppressors. In review, importance serving biomarkers targets system‑related was emphasized. Additionally, molecular mechanisms underlying involvement progression metastasis were explored. Furthermore, challenges are addressed future research directions advancing investigations related to system malignancies proposed.

Language: Английский

Citations

0

The roles of migrasomes in immunity, barriers, and diseases DOI

Changsheng Cai,

Jun Shen

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

0

The Role of Extracellular Vesicles in Liver Fibrosis: Friends or Foes? DOI Creative Commons
Xiang Tao, Can Chen, Mei Liu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2665 - 2665

Published: Nov. 22, 2024

Liver fibrosis represents a common pathway in the progression of various chronic liver diseases towards cirrhosis and failure. Extracellular vesicles (EVs) are membrane-enclosed particles secreted by diverse cell types, including exosomes, microvesicles, apoptotic vesicles, recently identified migrasomes. These can be taken up recipient cells, thereby modulating their function through transport cargo molecules. EVs facilitate intercellular communication play significant role development fibrosis. Moreover, detection body fluids offers sensitive diagnostic tools for assessing Additionally, may serve as therapeutic targets, potential agents, drug delivery vehicles. This article reviews recent advances field concerning related diseases, with particular focus on newly discovered migrasomes intracellular crosstalk within liver.

Language: Английский

Citations

0

Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles DOI Creative Commons

Javier Huete-Acevedo,

Cristina Mas‐Bargues,

Marta Arnal-Forné

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1493 - 1493

Published: Dec. 6, 2024

Extracellular vesicles (EVs) are small, membrane-bound particles secreted by cells into the extracellular environment, playing an increasingly recognized role in inter-organ communication and regulation of various physiological processes. Regarding redox homeostasis context, EVs play a pivotal propagating mitigating oxidative stress signals across different organs. Cells under release containing signaling molecules that can influence status distant tissues. starting to be as contributors brain-liver communication. Therefore, this review, we show how imbalance affect brain liver. We propose mediators axis.

Language: Английский

Citations

0