Identification and validation of PANoptosis-based HNSCPAN-index as a prognostic model for head and neck squamous cell carcinoma DOI Creative Commons
Yun Feng,

Qinglai Tang,

Xiaojun Tang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract PANoptosis, a recently characterized form of programmed cell death, remains incompletely understood in the context Head and Neck Squamous Cell Carcinoma (HNSCC). In this study, we identified prognostically relevant set PANoptosis genes within The Cancer Genome Atlas (TCGA) database for HNSCC uncovered three molecular subtypes based on their expression profiles. Each subtype exhibited distinct prognostic outcomes immune infiltration patterns. To further elucidate clinical relevance, constructed risk score model, termed HNSCPAN-index, using least absolute shrinkage selection operator (LASSO) Cox regression differentially expressed across subtypes. Patients were stratified into high-risk low-risk groups according to HNSCPAN-index. predictive power model was evaluated Kaplan-Meier analysis, ROC, nomogram validated an external dataset. A lower HNSCPAN-index correlated with longer overall survival enhanced immunotherapy responses, whereas higher indicated increased sensitivity small-molecule targeted therapies. Moreover, demonstrated strong correlation chemotherapeutic drug sensitivity. Finally, DSCAM as key regulator HNSCC, where silencing death mediated by pyroptosis inducers. conclusion, revealed its potential role prognosis, TME, chemotherapy. These findings may provide deeper understanding pave way development more personalized therapeutic strategies.

Language: Английский

SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis DOI Creative Commons
Fanghui Chen, Liwei Lang, Jianqiang Yang

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 9, 2025

Language: Английский

Citations

1
PANoptosis in autoimmune diseases interplay between apoptosis, necrosis, and pyroptosis DOI Creative Commons

Kangnan Liu,

Mi Wang,

Dongdong Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 31, 2024

PANoptosis is a newly identified inflammatory programmed cell death (PCD) that involves the interplay of apoptosis, necrosis, and pyroptosis. However, its overall biological effects cannot be attributed to any one type PCD alone. regulated by signaling cascade triggered recognition pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs) various sensors. This triggers assembly PANoptosome, which integrates key components from other pathways via adapters ultimately activates downstream execution molecules, resulting in with necrotic, apoptotic, pyroptotic features. Autoimmune diseases are characterized reduced immune tolerance self-antigens, leading abnormal responses, often accompanied systemic chronic inflammation. Consequently, PANoptosis, as unique innate immune-inflammatory pathway, has significant pathophysiological relevance inflammation autoimmunity. most previous research on focused tumors infectious diseases, leaving activation role autoimmune unclear. review briefly outlines characteristics summarizes several PANoptosome complexes, their mechanisms, components. We also explored dual potential therapeutic approaches targeting PANoptosis. Additionally, we existing evidence for explore regulatory mechanisms involved.

Language: Английский

Citations

4
Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy DOI Creative Commons

Yonghua Cai,

Heng Xiao, Shuaishuai Xue

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: Feb. 3, 2025

Glioma, particularly glioblastoma (GBM), is a highly aggressive tumor with limited responsiveness to immunotherapy. PANoptosis, form of programmed cell death merging pyroptosis, apoptosis, and necroptosis, plays an important role in reshaping the microenvironment (TME) enhancing immunotherapy effectiveness. This study investigates PANoptosis dynamics glioma explores therapeutic potential its activation, through natural compounds such as cinobufagin. We comprehensively analyzed PANoptosis-related genes (PANoRGs) multiple cohorts, identifying different patterns constructing enrichment score (PANoScore) evaluate relationship patient prognosis immune activity. Cinobufagin, identified activator, was evaluated for ability induce enhance anti-tumor responses both vitro vivo GBM models. Our findings indicate that high PANoScore gliomas showed increased infiltration, effector T cells, enhanced sensitivity immunotherapies. Cinobufagin effectively induced leading immunogenic death, facilitated tumor-associated microglia/macrophages (TAMs) polarization towards M1-like phenotype while augmenting CD4+/CD8 + infiltration activation. Importantly, cinobufagin combined anti-PD-1 therapy exhibited significant synergistic effects prolonged survival These highlight PANoptosis-targeting agents, cinobufagin, combination immunotherapy, offering promising approach convert "cold" tumors into "hot" ones improving treatment outcomes.

Language: Английский

Citations

0
Current Evidence and Therapeutic Implications of PANoptosis in Sepsis DOI

增凤 王

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 2490 - 2504

Published: Jan. 1, 2025

Language: Английский

Citations

0
Polyallylamine Hydrochloride-Modified Bovine Serum Albumin Nanoparticles Loaded with α-Solanine for Chemotherapy of Pancreatic Cancer DOI Creative Commons
Zhengde Wen,

Shan Luo,

Juntao Liu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 4235 - 4255

Published: April 1, 2025

α-Solanine (α-Sol) shows promise for pancreatic cancer (PC) treatment by inhibiting PC cell proliferation, migration, and invasion. However, its clinical application is hindered poor tumor targeting, significant toxicity, undesirable pharmacokinetics. To address these issues, this study developed a nanoparticle delivery system (PBSO NPs) using bovine serum albumin as carrier, with polyallylamine hydrochloride surface modification to enhance α-Sol delivery. PBSO NPs were characterized transmission electron microscopy, dynamic light scattering, size analyzers, Fourier-transform infrared spectroscopy. Their in vitro drug release profile cellular uptake capabilities evaluated. Furthermore, experiments conducted mouse cells (Panc02) investigate the effects of on Panc02 viability, invasion, apoptosis. Additionally, xenograft model was established vivo explore impact growth. This successfully favorable morphology physiological stability, capable enhancing uptake. In demonstrated that significantly inhibited invasion while promoting Moreover, enhanced inhibitory cells. further confirmed improved therapeutic efficacy against partially reducing toxicity. exhibited good biocompatibility. apoptosis, thereby suppressing progression PC. provides promising strategy treatment.

Language: Английский

Citations

0
PGAM5 promotes RIPK1-PANoptosome activity by phosphorylating and activating RIPK1 to mediate PANoptosis after subarachnoid hemorrhage in rats DOI
Jiajia Duan, Y. Edward Wen,

Jiang Enyan

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 384, P. 115072 - 115072

Published: Nov. 26, 2024

Language: Английский

Citations

2
Identification and validation of PANoptosis-based HNSCPAN-index as a prognostic model for head and neck squamous cell carcinoma DOI Creative Commons
Yun Feng,

Qinglai Tang,

Xiaojun Tang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract PANoptosis, a recently characterized form of programmed cell death, remains incompletely understood in the context Head and Neck Squamous Cell Carcinoma (HNSCC). In this study, we identified prognostically relevant set PANoptosis genes within The Cancer Genome Atlas (TCGA) database for HNSCC uncovered three molecular subtypes based on their expression profiles. Each subtype exhibited distinct prognostic outcomes immune infiltration patterns. To further elucidate clinical relevance, constructed risk score model, termed HNSCPAN-index, using least absolute shrinkage selection operator (LASSO) Cox regression differentially expressed across subtypes. Patients were stratified into high-risk low-risk groups according to HNSCPAN-index. predictive power model was evaluated Kaplan-Meier analysis, ROC, nomogram validated an external dataset. A lower HNSCPAN-index correlated with longer overall survival enhanced immunotherapy responses, whereas higher indicated increased sensitivity small-molecule targeted therapies. Moreover, demonstrated strong correlation chemotherapeutic drug sensitivity. Finally, DSCAM as key regulator HNSCC, where silencing death mediated by pyroptosis inducers. conclusion, revealed its potential role prognosis, TME, chemotherapy. These findings may provide deeper understanding pave way development more personalized therapeutic strategies.

Language: Английский

Citations

0