Exosome-transmitted LUCAT1 promotes stemness transformation and chemoresistance in bladder cancer by binding to IGF2BP2

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: March 3, 2025

Abstract The chemotherapy resistance is an awkward challenge in management of bladder cancer (BC). Cancer organoid model effective preclinical tumor that could faithfully represent clinical manifestations and simulate the biological processes chemoresistance. Recent studies have revealed stem cells (CSCs) play a significant role development chemoresistance cancer. Exosomes act as essential intercellular messengers participate controlling conversion distinct cell characteristics, including However, exosome-transmitted lncRNAs has rarely been reported. In this study, models were developed from urothelial carcinomas to explore pathophysiology mechanism BC chemoresistance, RNA-seq was performed screen for involved BC. We found enriches stem-like BC, upregulation Lung Associated Transcript 1 (LUCAT1) occurs chemotherapy-resistant organoids correlated with response. Further experimental results demonstrated LUCAT1 promotes by enhancing stemness phenotype vivo vitro. Moreover, exosomes derived can enhance delivering LUCAT1. Mechanistically, significantly mRNA stability HMGA1 via binding IGF2BP2 m6A-dependent manner. study demonstrates important potential function both diagnostic biomarker therapeutic target

Language: Английский

Extracellular vesicles: messengers of cross-talk between gastric cancer cells and the tumor microenvironment

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 16, 2025

Gastric cancer is a common malignancy characterized by an insidious onset and high mortality rate. Exosomes, special type of extracellular vesicle, contain various bioactive molecules have been found to play crucial roles in maintaining normal physiological functions homeostasis the body. Recent research has shown that contents exosome significant role progression metastasis gastric through communication regulatory functions. These mechanisms involve promoting cell proliferation drug resistance. Additionally, other cells microenvironment can regulate exosomes. include exosomes derived from fibroblasts immune cells, which modulate cells. Therefore, this review, we provide brief overview recent advances occurrence exosome. This review specifically focused on cellular subtypes tumor microenvironment. Subsequently, summarize latest progress use liquid biopsy, discussing potential clinical applications.

Language: Английский