Refining Lung Cancer Brain Metastasis Models for Spatiotemporal Dynamic Research and Personalized Therapy DOI Open Access
Ying Chen, Ao Zhang,

Jing-Rong Wang

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1588 - 1588

Published: May 7, 2025

Lung cancer brain metastasis (LCBM) is a major contributor to cancer-related mortality, with median survival of 8–16 months following diagnosis, despite advances in therapeutic strategies. The development clinically relevant animal models crucial for understanding the metastatic cascade and assessing therapies that can penetrate blood–brain barrier (BBB). This review critically evaluates five primary LCBM modeling approaches—orthotopic implantation, intracardiac injection, stereotactic intracranial carotid artery tail vein injection—focusing on their clinical applicability. We systematically compare ability replicate human pathophysiology highlight emerging technologies personalized therapy screening. Additionally, we analyze breakthrough strategies central nervous system (CNS)-targeted drug delivery, including microparticle targeted delivery systems designed enhance accumulation. By incorporating single-cell omics AI-driven prediction, this work provides roadmap next generation models, aimed at bridging preclinical research.

Language: Английский

Hormonal and Neuronal Interactions Shaping the Brain Metastatic Microenvironment DOI Creative Commons

Stephen Shovlin,

Leonie S. Young, Damir Varešlija

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217739 - 217739

Published: April 1, 2025

Language: Английский

Citations

0
Nanoparticle-mediated dual targeting of stromal and immune components to overcome fibrotic and immunosuppressive barriers in hepatocellular carcinoma DOI

Xiangyi Yin,

Xingyang Zhao,

Yiming Shen

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113783 - 113783

Published: April 1, 2025

Language: Английский

Citations

0
Identification of GABA producing strains from sourdoughs and optimization of GABA production by response surface-integrated particle swarm approach DOI
Zühal Alkay, Abdullah Tahir Şensoy, Muhammed Zeki Durak

et al.

Preparative Biochemistry & Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 30, 2025

Lactic Acid Bacteria (LAB) strains were isolated from sourdough samples collected five provinces of Türkiye and the Cyprus region. The gamma-aminobutyric acid (GABA) production ability these LAB with (+) gad gene regions was evaluated. Response Surface Method (RSM) Particle Swarm Optimization (PSO) techniques used together to optimize GABA environment Levilactobacillus brevis SD48 strain highest production. fermentation conditions for designed Box-Behnken design. parameters tested pH, temperature, time monosodium glutamate (MSG) concentration. Fermentation (24, 48, 72 hours), pH values (4.5, 5.75 7.0), temperature (30, 35 40 °C), MSG concentration (50, 225, 400 mM) taken. It seen that best process allow maximum yield should be 30 °C, 130.71 mM, 4.74 hour. According results, it can thought microbial is both cheap optimized we determined will play an important role in GABA-rich fermented foods.

Language: Английский

Citations

0
Characteristics and Treatment Advances of Postoperative Brain Metastasis in Different Lung Cancer Histological Types DOI Creative Commons
Chang‐Ming Dong,

Xuebin Yu,

Wuqiao Bao

et al.

Current Problems in Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 101785 - 101785

Published: May 1, 2025

Language: Английский

Citations

0
Refining Lung Cancer Brain Metastasis Models for Spatiotemporal Dynamic Research and Personalized Therapy DOI Open Access
Ying Chen, Ao Zhang,

Jing-Rong Wang

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1588 - 1588

Published: May 7, 2025

Lung cancer brain metastasis (LCBM) is a major contributor to cancer-related mortality, with median survival of 8–16 months following diagnosis, despite advances in therapeutic strategies. The development clinically relevant animal models crucial for understanding the metastatic cascade and assessing therapies that can penetrate blood–brain barrier (BBB). This review critically evaluates five primary LCBM modeling approaches—orthotopic implantation, intracardiac injection, stereotactic intracranial carotid artery tail vein injection—focusing on their clinical applicability. We systematically compare ability replicate human pathophysiology highlight emerging technologies personalized therapy screening. Additionally, we analyze breakthrough strategies central nervous system (CNS)-targeted drug delivery, including microparticle targeted delivery systems designed enhance accumulation. By incorporating single-cell omics AI-driven prediction, this work provides roadmap next generation models, aimed at bridging preclinical research.

Language: Английский

Citations

0