[High expression of secretogranin II increases oxaliplatin resistance of colorectal cancer cells]. DOI
Jinhai Deng, Tao Pan, Ge Zhou

et al.

PubMed, Journal Year: 2023, Volume and Issue: 43(10), P. 1657 - 1664

Published: Oct. 20, 2023

To investigate the expression of secretogranin II (SCG2) in colorectal cancer (CRC) tissues and its impact on oxaliplatin resistance CRC cells.We performed immunohistochemistry to detect level SCG2 a tissue microarray containing 96 84 adjacent analyzed association with clinical features patients. was also measured DLD1 cells treated using immunoblotting RT-qPCR analyses. The effects sensitivity cell viability were evaluated model knockout established CRISPR-cas9 technique, expressions apoptosis-related proteins detected Western blotting RT-qPCR. We further examined levels an oxaliplatin-resistant line parental cells.SCG2 significantly increased as compared (1.932±0.816 vs 1), tumor advanced stages showed higher levels. In cells, treatment expression, obviously enhanced proteins. Compared significant increase by 3.901±0.471 folds.SCG2 may serve risk gene CRC, high increases cells.

Language: Английский

Extracellular vesicles as tools and targets in therapy for diseases DOI Creative Commons

Mudasir A. Kumar,

Sadaf Khursheed Baba,

Hana Q. Sadida

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 5, 2024

Abstract Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers ubiquitously released from cells under normal pathological conditions. Human serum is a rich source of these EVs, though their isolation proteins non-EV lipid particles poses challenges. These transport various cellular components such as proteins, mRNAs, miRNAs, DNA, lipids across distances, influencing numerous physiological events, including those within tumor microenvironment (TME). Their pivotal roles in communication make EVs promising candidates for therapeutic agents, drug delivery systems, disease biomarkers. Especially cancer diagnostics, EV detection can pave way early identification offers potential diagnostic Moreover, subtypes emerging targeted tools, highlighting clinical significance. The need non-invasive biomarkers to monitor biological processes purposes remains unfulfilled. Tapping unique composition could unlock advanced avenues future. In this review, we discuss detail conditions, cancers (encompassing head neck, lung, gastric, breast, hepatocellular carcinoma), neurodegenerative disorders, diabetes, viral infections, autoimmune renal diseases, emphasizing advancements molecular diagnostics delivery.

Language: Английский

Citations

291
Research progress in tumor angiogenesis and drug resistance in breast cancer DOI Creative Commons

Jiancheng Mou,

Chenhong Li, Qinghui Zheng

et al.

Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: June 25, 2024

Angiogenesis is considered a hallmark pathophysiological process in tumor development. Aberrant vasculature resulting from angiogenesis plays critical role the development of resistance to breast cancer treatments,

Language: Английский

Citations

17
Enhanced pharmacokinetic approach for anastrozole in macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for estrogen-positive breast cancer therapy DOI
Arfa Nasrine, Sourav Mohanto,

Soumya Narayana

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Jan. 3, 2025

Breast cancer (BC) is a substantial reason for cancer-related mortality among women across the globe. Anastrozole (ANS) an effective orally administered hormonal therapy estrogen+ (ER+) BC treatment. However, several side effects and pharmacokinetic limitations restricted its uses in Therefore, this study developed

Language: Английский

Citations

1
Role of circular RNAs in cancer therapy resistance DOI Creative Commons
Wenjuan Liu,

Jiling Niu,

Yanfei Huo

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 25, 2025

Over the past decade, circular RNAs (circRNAs) have gained recognition as a novel class of genetic molecules, many which are implicated in cancer pathogenesis via different mechanisms, including drug resistance, immune escape, and radio-resistance. ExosomalcircRNAs, particular, facilitatecommunication between tumour cells micro-environmental cells, fibroblasts, other components. Notably, can reportedly influence progression treatment resistance by releasing exosomalcircRNAs. circRNAs often exhibit tissue- cancer-specific expression patterns, growing evidence highlights their potential clinical relevance utility. These molecules show strong promise biomarkers therapeutic targets for diagnosis treatment. Therefore, this review aimed to briefly discuss latest findings on roles mechanisms key various malignancies, lung, breast, liver, colorectal, gastric cancers, well haematological malignancies neuroblastoma.This will contribute identification new circRNA early cancer.

Language: Английский

Citations

1
Drug resistance in breast cancer is based on the mechanism of exocrine non-coding RNA DOI Creative Commons

Simin Ye,

Shiyu Chen, Xiaoyan Yang

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 1, 2024

Breast cancer (BC) ranks first among female malignant tumors and involves hormonal changes genetic as well environmental risk factors. In recent years, with the improvement of medical treatment, a variety therapeutic approaches for breast have emerged strengthened to accommodate molecular diversity. However, primary way improve effective treatment patients is overcome resistance. Recent studies provided insights into mechanisms resistance exosome effects in BC. Exosomes are membrane-bound vesicles secreted by both healthy cells that facilitate intercellular communication. Specifically, exosomes released tumor transport their contents recipient cells, altering properties promoting oncogenic components, ultimately resulting drug As important coordinators, non-coding RNAs (ncRNAs) involved this process aberrantly expressed various human cancers. Exosome-derived ncRNAs, including microRNAs (miRNAs), long-noncoding (lncRNAs), circular (circRNAs), crucial components understanding cancer. This review provides mechanism exosome-derived ncRNAs resistance, thereby suggesting new strategies

Language: Английский

Citations

5
Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m6A-modified PTEN mRNA in pancreatic ductal adenocarcinoma DOI
Dandan Zheng, Wenying Chen, Juanfei Peng

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(7), P. 1090 - 1102

Published: May 27, 2024

Language: Английский

Citations

4
Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities DOI Creative Commons
Junshu Li, Wencheng Zhou, Huiling Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 24, 2024

Exosomes can regulate the malignant progression of tumors by carrying a variety genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, immune escape. In microenvironment (TME), circRNAs be transferred among cells, endothelial cancer-associated fibroblasts, microbiota, affecting initiation progression. Due high stability widespread presence circRNAs, they hold promise biomarkers for diagnosis prognosis prediction blood urine. addition, designing nanoparticles targeting utilizing derived from cells or stem provide new strategies cancer therapy. this review, we examined crucial role regulating tumor-related signaling pathways summarized transmission between various types their impact on TME. Finally, our review highlights potential diagnostic prognostic biomarkers, well suggesting clinical

Language: Английский

Citations

4
Exosome-Mediated Cellular Communication in the Tumor Microenvironment Imparts Drug Resistance in Breast Cancer DOI Open Access
Rama Rao Malla,

Priyamvada Bhamidipati,

Anuveda Sree Samudrala

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1167 - 1167

Published: March 30, 2025

Globally, breast cancer (BC) is the leading cause of cancer-related death for women. BC characterized by heterogeneity, aggressive behavior, and high metastatic potential. Chemotherapy, administered as monotherapy or adjuvant therapy, remains a cornerstone treatment; however, acquired drug resistance significant clinical challenge. Deciphering mechanisms will be central to developing more efficient treatment options improving patient outcomes. The current review examines multifaceted nature exosomes in conferring through complex communication networks within tumor microenvironment. We further explore recent advances understanding how contribute against established chemotherapeutic agents such tamoxifen, paclitaxel, doxorubicin, platinum-based drugs, trastuzumab, newer immunotherapies, immune checkpoint inhibitors. Moreover, we discuss existing systematic approaches investigating exosome-drug relationship BC. Finally, promising therapeutic overcome exosome-dependent BC, highlighting potential avenues improved efficacy. Investigating distinct functions cargo offers innovative overcoming resistance.

Language: Английский

Citations

0
Exosomal circRNAs: key modulators in breast cancer progression DOI Creative Commons
Guozhen Liu, Quan Liu,

Lingmei Jia

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 24, 2025

Abstract Breast cancer (BC) poses significant challenges globally, necessitating a deeper understanding of its complexities. Exosomes are cell-specific secreted extracellular vesicles interest, characterized by lipid bilayer structure. can carry variety bioactive components, including nucleic acids, lipids, amino and small molecules, to mediate intercellular signaling. CircRNAs novel class single-stranded RNA closed-loop mainly exert ceRNA functions intricately modulate gene expression signaling pathways in breast cancer, influencing tumor progression therapeutic responses. The unique packaging circRNAs within exosomes serves as genetic information transmitters, facilitating communication between BC cells microenvironmental cells, thereby regulating critical aspects progression, immune evasion, drug resistance. Besides, exosomal possess the capabilities serving diagnostic biomarkers BC, due their stability, specificity, regulatory roles tumorigenesis metastasis. Therefore, this review aims elucidate mechanisms well potential for diagnosis therapeutics. ongoing investigations will potentially revolutionize treatment paradigms improve patient outcomes BC.

Language: Английский

Citations

0
Circular RNAs in cancer DOI Creative Commons
Yang Guo, Qiang Huang,

Heng Yu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Feb. 1, 2025

Abstract Circular RNA (circRNA), a subtype of noncoding RNA, has emerged as significant focus in research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles diverse physiological and pathological processes, functioning through mechanisms such miRNAs or proteins sponging, regulation splicing gene expression, serving translation templates, particularly the context various cancers. The hallmarks cancer comprise functional capabilities acquired during carcinogenesis tumor progression, providing conceptual framework that elucidates nature malignant transformation. Although numerous studies have elucidated role circRNAs cancers, their functions development chemoradiotherapy resistance remain unexplored clinical applications circRNA‐based translational therapeutics are still infancy. This review provides comprehensive overview circRNAs, covering biogenesis, unique characteristics, functions, turnover mechanisms. We also summarize involvement relevance biomarkers therapeutic targets, especially thyroid (TC). Considering potential fascination therapeutics, “Ying‐Yang” dynamic regulations TC warrant vastly dedicated investigations.

Language: Английский

Citations

0