Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer DOI Creative Commons
Alexandra Ritchie,

Priyal Dhawan,

Eveliina Kailari

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

ABSTRACT Basement membrane (BM) supports and regulates the structural integrity, function differentiation of epithelial tissues protects against stromal invasion breast cancer cells. Here we show that LAMA5, a central BM component, is critical for luminal mammary tumour initiation, controls tumor progression phenotype development. LAMA5 overexpressed in both human mouse tumours downregulation attenuates growth Prepubertal deletion Lama5 MMTV-PyMT mice results marked reduction emergence early hyperplasias, along with shift from mature hormone receptor (HR+) positive towards HR+ progenitor phenotype, widespread alterations extracellular matrix Fibroblast factor (Fgf) signalling genes, including overexpression Fgf 2 (Fgfr2) Single allele deletion, but not biallelic additionally inhibits advanced carcinomas. However, inhibition receptors restores decrease induces apoptosis biallelic- Lama5- deleted organoids without affecting wildtype organoids. Our analyses demonstrate role component initiation reveal mechanisms matrix-epithelial interplay maintenance.

Language: Английский

Understanding the Electrochemical MOF Sensors in Detecting Cancer with Special Emphasis on Breast Carcinoma Biomarkers DOI
Brij Mohan, Krunal Modi, Gurjaspreet Singh

et al.

Topics in Current Chemistry, Journal Year: 2025, Volume and Issue: 383(1)

Published: Feb. 18, 2025

Language: Английский

Citations

1
15th Annual ENBDC Meeting: How do Cellular Potency, Microenvironment and Natural Rhythms Influence Mammary Gland Biology and Breast Cancer? DOI Creative Commons
Maria Rafaeva, Beata Kaczyńska, Jaime Redondo-Pedraza

et al.

Journal of Mammary Gland Biology and Neoplasia, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 25, 2024

Following previous editions, the fifteenth annual workshop of European Network for Breast Development and Cancer (ENBDC) on Methods in Mammary Gland Biology was held from 2nd to 4th May Weggis, Switzerland. Over course this meeting, participants followed discussed presentations a roster internationally renowned invited speakers selected abstracts, complemented with two poster sessions covering exciting unpublished results. The covered projects normal mammary gland development, breast cancer evolution metastasis, as well epigenetic metabolic regulation cancer. As last year, early career researchers (ECR) hosted pre-workshop day, when stage provided allow PhD students postdocs showcase their results, they had ample time discussions experimental settings planning, while interacting several guests.

Language: Английский

Citations

1
Integrin α6 and integrin β4 in exosomes promote lung metastasis of colorectal cancer DOI Open Access

Fengyun Cong,

Jiahao Huang,

Changtao Wu

et al.

Journal of Cancer Research and Therapeutics, Journal Year: 2024, Volume and Issue: 20(7), P. 2082 - 2093

Published: Dec. 1, 2024

Language: Английский

Citations

0
Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer DOI Creative Commons
Alexandra Ritchie,

Priyal Dhawan,

Eveliina Kailari

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

ABSTRACT Basement membrane (BM) supports and regulates the structural integrity, function differentiation of epithelial tissues protects against stromal invasion breast cancer cells. Here we show that LAMA5, a central BM component, is critical for luminal mammary tumour initiation, controls tumor progression phenotype development. LAMA5 overexpressed in both human mouse tumours downregulation attenuates growth Prepubertal deletion Lama5 MMTV-PyMT mice results marked reduction emergence early hyperplasias, along with shift from mature hormone receptor (HR+) positive towards HR+ progenitor phenotype, widespread alterations extracellular matrix Fibroblast factor (Fgf) signalling genes, including overexpression Fgf 2 (Fgfr2) Single allele deletion, but not biallelic additionally inhibits advanced carcinomas. However, inhibition receptors restores decrease induces apoptosis biallelic- Lama5- deleted organoids without affecting wildtype organoids. Our analyses demonstrate role component initiation reveal mechanisms matrix-epithelial interplay maintenance.

Language: Английский

Citations

0