Scientia Horticulturae, Journal Year: 2024, Volume and Issue: 338, P. 113711 - 113711
Published: Oct. 11, 2024
Language: Английский
Genome biology, Journal Year: 2024, Volume and Issue: 25(1)
Published: March 11, 2024
Abstract Background Bromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes trimethylation lysine 27 H3 (H3K27me3), an epigenetic hallmark gene silencing. However, whether and how participates transcriptional repression remains poorly understood. Results We report that forms phase-separated liquid condensates to modulate its biological function Fusarium graminearum . Deletion assays reveal intrinsically disordered region 2 (IDR2) mediates liquid–liquid phase separation. The separation indispensable for interaction with suppressor Zeste 12, component polycomb repressive complex 2. Furthermore, IDR2 deletion abolishes BP1-H3K27me3 binding alleviates the secondary metabolism-related genes, especially deoxynivalenol mycotoxin biosynthesis genes. Conclusions maintains by forming condensates, expanding our understanding relationship between
Language: Английский
Citations
9
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: March 31, 2025
Liquid-liquid phase separation (LLPS) is a pivotal biophysical phenomenon that plays critical role in cellular organization and has garnered significant attention the fields of molecular mechanism pathophysiology cancer. This dynamic process involves spontaneous segregation biomolecules, primarily proteins nucleic acids, into condensed, liquid-like droplets under specific conditions. LLPS drives formation biomolecular condensates, which are crucial for various functions. Increasing evidences link alterations to onset progression diseases, particularly review explores diverse roles cancer, highlighting its underlying mechanisms far-reaching implications. We examine how dysregulated contributes cancer development by influencing key processes such as genomic instability, metabolism, immune evasion. Furthermore, we discuss emerging therapeutic strategies aimed at modulating LLPS, underscoring their potential revolutionize treatment.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 575 - 575
Published: April 12, 2025
Diabetic retinopathy (DR) is a microvascular complication arising as secondary effect of diabetes, with both genetic and environmental factors playing significant role in its onset progression. Epigenetics serves the crucial link between these influences. Among various epigenetic mechanisms, histone modification stands out key regulatory process associated development many diseases. Histone modifications primarily regulate cellular function by influencing gene expression. Modulating modifications, particularly through regulation enzymes involved processes, holds promising therapeutic approach for managing diseases like DR. In this review, we explore mechanisms contribution to pathogenesis
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 17, 2025
Breast cancer (BC) is one of the most prevalent malignant tumors among women globally, with number cases accounting for even more than 1/3 all tumor patients in women. Recent studies have found that incidence BC increasing every year. Despite great progress made treatment, characteristics cells, such as strong immune evasion, easy recurrence and drug resistance, are still main reasons limiting survival patients. Epigenetics becoming an important method to reveal development cancer, mainly through study DNA methylation, histone modification, chromatin structure changes non-coding RNA. In addition, researchers epigenetic markers potential early detection personalized treatment BC. Inhibitors targeting epigenetically modified enzymes effective treating a wide range provide significant patient quality life. Therefore, this review will comprehensively summarize role modifications development. Second, paper focus on summarizing how induce formation microenvironment (TIME) Targeting mechanism action provides new perspectives unravel complex process development, while paving way novel diagnostic therapeutic targets. future, by integrating multi-omics data enable deeper understanding pathogenesis BC, we be able promote overall precision medicine.
Language: Английский
Citations
0
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 473, P. 134576 - 134576
Published: May 12, 2024
Language: Английский
Citations
3
MedComm – Oncology, Journal Year: 2025, Volume and Issue: 4(2)
Published: May 5, 2025
ABSTRACT Liquid–liquid phase separation (LLPS) plays a critical role in orchestrating various cellular processes, such as gene expression, signal transduction, and protein synthesis, by compartmentalizing components without membrane boundaries. Emerging research has illuminated how dysregulated LLPS is integral to cancer development influencing tumorigenesis, metastasis, immune system evasion, resistance therapy. The subtle differences are crucial for understanding progression finding new treatments. However, despite its significant implications oncology, the potential of specifically targeting therapy not been thoroughly investigated. This review delves into mechanisms LLPS, exploring physiological triggers their consequences biology. We discuss profound impact on hallmarks outline innovative strategies aimed at LLPS. These include direct inhibition condensate formation modulation related signaling pathways. Although poses several challenges, specificity delivery methods, it represents promising frontier treatment, potentially revolutionizing we approach emphasizes academic therapeutic importance advocating an exciting valuable target future treatment strategies.
Language: Английский
Citations
0
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(66), P. 8732 - 8735
Published: Jan. 1, 2024
A highly sensitive method is proposed for obtaining the Raman spectra of low-concentration proteins and nucleic acids in an aqueous solution using liquid–liquid phase separation.
Language: Английский
Citations
1
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117654 - 117654
Published: Nov. 9, 2024
Language: Английский
Citations
0
Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217408 - 217408
Published: Dec. 1, 2024
Language: Английский
Citations
0
Scientia Horticulturae, Journal Year: 2024, Volume and Issue: 338, P. 113711 - 113711
Published: Oct. 11, 2024
Language: Английский
Citations
0