Novel Link Between Myeloid-Specific Adenosine Deaminase 2 and CXCL10-CXCR3 Axis in Infectious ARDS DOI Open Access

Shilpa Tiwari‐Heckler,

Yered Pita-Juárez, Lisa Vierbaum

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3678 - 3678

Published: April 13, 2025

Acute respiratory distress syndrome (ARDS) is a severe complication of lung injury characterized by hyperinflammation and fibrosis. Here, we show significant association between the monocyte-derived enzyme adenosine deaminase 2 (ADA2) SARS-CoV-2 induced ARDS. We note an interesting link ADA2 chemokine CXCL10 its receptor CXCR3. By using published datasets spatial transcriptomics single-cell RNAseq, that highly expressed inflammatory CD14+CD16+ monocytes, along with profibrotic genes, in lungs affected COVID-19. This study reveals important associations key pathophysiological features ARDS, linking hypoxia, infiltrative CXCR3 exoenzyme ADA2.

Language: Английский

Novel Link Between Myeloid-Specific Adenosine Deaminase 2 and CXCL10-CXCR3 Axis in Infectious ARDS DOI Open Access

Shilpa Tiwari‐Heckler,

Yered Pita-Juárez, Lisa Vierbaum

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3678 - 3678

Published: April 13, 2025

Acute respiratory distress syndrome (ARDS) is a severe complication of lung injury characterized by hyperinflammation and fibrosis. Here, we show significant association between the monocyte-derived enzyme adenosine deaminase 2 (ADA2) SARS-CoV-2 induced ARDS. We note an interesting link ADA2 chemokine CXCL10 its receptor CXCR3. By using published datasets spatial transcriptomics single-cell RNAseq, that highly expressed inflammatory CD14+CD16+ monocytes, along with profibrotic genes, in lungs affected COVID-19. This study reveals important associations key pathophysiological features ARDS, linking hypoxia, infiltrative CXCR3 exoenzyme ADA2.

Language: Английский

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