Impact of UV-Irradiated Mesoporous Titania Nanoparticles (mTiNPs) on Key Onco- and Tumor Suppressor microRNAs of PC3 Prostate Cancer Cells

Genes, Journal Year: 2025, Volume and Issue: 16(2), P. 148 - 148

Published: Jan. 25, 2025

Background: Mesoporous titanium dioxide nanoparticles (mTiNPs) are known for their chemical stability, non-toxicity, antimicrobial and anticancer effects, as well photocatalytic properties. When this material is subjected to UV radiation, its electronic structure shifts, during that process, reactive oxygen species generated, which in turn exert apoptotic events on the cancer cells. Objectives: We evaluated cytotoxic effects of UV-irradiated mTiNPs prostate (PCa) cell line PC3 with aim demonstrating interaction between UV-light positively impacts nanomaterial’s efficiency. Moreover, we assessed differential expression key oncomiRs tumor suppressor (TS) miRNAs, associated target genes, cells undergoing treatment. Methods: PBS-suspended exposed 290 nm light were added at different concentrations Cell viability was determined after 24 h a crystal violet assay. Then, obtained IC50 concentration UV-nanomaterial applied new culture, set miRNAs selected genes via qRT-PCR. Results: The photo-activated required 4.38 times less nanomaterial than group non-irradiated achieve half-maximal inhibition, an improved performance mTiNPs. miR-18a-5p, miR-21-5p, miR-221-5p downregulated application UV-mTiNPs, while TS miR-200a-5p miR-200b-5p displayed upregulated expression. Among miRNA PTEN found be treatment, BCL-2 TP53 underexpressed. Conclusions: Our outcomes coincided previous reports performed other lines, strongly suggesting promising nano-therapeutic approach against PCa. On hand, best our knowledge, first report exploring impact onco- microRNAs PCa

Language: Английский

---

Bio‐Fabricated TiO₂ Nanoparticles: A Comprehensive Insight Into Its Antimicrobial, Anticancer, and Environmental Applications

Environmental Quality Management, Journal Year: 2024, Volume and Issue: 34(2)

Published: Nov. 26, 2024

ABSTRACT The increasing emphasis on environmental sustainability and the need for eco‐friendly solutions has intensified interest in bio‐fabricated titanium dioxide (TiO 2 ) nanoparticles due to their unique properties versatile applications. This review provides a comprehensive insight into synthesis of TiO using various biological sources, including plants microorganisms, highlighting advantages green methods over conventional techniques. antimicrobial activity against range pathogens, Escherichia coli, Bacillus subtilis , opportunistic species Staphylococcus, Teschovirus A, Trichoderma, Candida albicans been examined scripted research papers, along with underlying mechanisms that contribute efficacy. Additionally, potential cancer therapy is explored, focusing ability induce apoptosis cells applications photodynamic therapy. Furthermore, discussion nanoparticles, role wastewater treatment, air purification, as photocatalysts degradation organic pollutants, agriculture, energy production, electronic sensing emphasized its importance maintaining sustainability. By elucidating multifaceted roles this study underscores promising alternative healthcare management, paving way future nanotechnology.

Language: Английский

---

Evaluation of Titanium Dioxide/Catechol Polyurethane Composite for Antimicrobial Resistance, and Wastewater Treatment

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

In this study, a novel approach for the environmentally conscious extraction of titanium dioxide (TiO₂) from ilmenite ore while limiting environmental impact and enhancing advantage an economic process. Leaching conditions were tested with different acids effective separation TiO₂ optimized concerning experimental parameters. TiO₂NPs characterized using tools. Catechol polyurethane foam immobilized (CAT-PUF/TiO₂) was prepared its antimicrobial action against Gram-negative Bacterium E. coli, Gram-positive bacterium B. cereus, fungus A. niger. CAT-PUF /TiO₂ showed effect niger inhibition zones 27 ± 0.14, 12 22 0.06 mm, respectively. Incorporating bioinformatics, research contributes to burgeoning field nanotechnology-enabled materials, offering insights into potential applications CAT-PUF/TiO₂ in combating microbial threats. Through bio-informatics tools, toxicity synthesized nanoparticles assessed, providing valuable their safety profile impact. Furthermore, simulating binding affinity between target biomolecules, such as cell membrane proteins or enzyme receptors, aspect sheds light on mechanistic underpinnings efficacy.

Language: Английский

---

Evaluation of titanium dioxide/catechol polyurethane composite for antimicrobial resistance and wastewater treatment

Discover Materials, Journal Year: 2024, Volume and Issue: 4(1)

Published: Nov. 1, 2024

In this study, a novel approach for the environmentally conscious extraction of titanium dioxide from ilmenite ore while limiting environmental impact and enhancing advantage an economic process. Leaching conditions were tested with different acids effective separation TiO2 optimized concerning experimental parameters. TiO2NPs characterized using tools. Catechol polyurethane foam immobilized was prepared its antimicrobial action against Gram-negative bacterium E. coli, Gram-positive B. cereus, fungus A. niger. CAT-PUF /TiO2NPs showed effect niger inhibition zones 27 ± 0.14, 12 22 0.06 mm, respectively. Incorporating bioinformatics, research contributes to burgeoning field nanotechnology-enabled materials, offering insights into potential applications CAT-PUF/TiO2NPs in combating microbial threats. Through bio-informatics tools, toxicity synthesized nanoparticles assessed, providing valuable their safety profile impact. Furthermore, simulating binding affinity between target biomolecules, such as cell membrane proteins or enzyme receptors, aspect sheds light on mechanistic underpinnings efficacy.

Language: Английский

---