Preparation and kinetic studies of a new antibacterial sodium alginate gelatin hydrogel composite DOI Creative Commons

Reem A. ElTatawy,

Amel M. Ismail, Mohammed Salah Ayoup

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 25, 2024

This study involved synthesis of a novel antibacterial heterocyclic compound, sodium 2-(2-(3-phenyl-1, 2, 4-oxadiazol-5-yl) phenoxy) acetate abbreviated as Na-POPA. Further development biocompatible, pH-responsive hydrogel drug carrier prepared utilizing the natural polymers gelatin and alginate. The compound loaded on represented new delivery system. Comprehensive characterization Na-POPA was performed using Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (¹H NMR), carbon-13 (¹³C high-resolution mass spectrometry (HRMS). onto alginate/gelatin under feasible experimental conditions. successful incorporation into matrix confirmed via scanning electron microscopy (SEM), powder X-ray diffraction (pXRD) analysis FT-IR spectroscopy. Cytotoxicity assays revealed that all unloaded induced cell toxicity at large concentration much lower than many reported results. reduced inherent cytotoxicity enhanced its biocompatibility. release kinetics from were evaluated spectrophotometrically different pH conditions simulating biological fluids. rate 1.2 greater 6.8, with higher cumulative observed 6.8. obeyed pseudo-second-order kinetic model, indicating controlled mechanism influenced by hydrogel's physicochemical properties. Electrochemical impedance cyclic voltammetry further pH-dependent. high swelling solubility 6.8 enhance release. larger amount released (target intestine) because more solubility, leaching rather shrinking.

Language: Английский

Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review DOI Creative Commons

Hussam Elddin Nabeih Khasawneh,

Ali Abdulrazzaq Abdulhussein Alrikabi,

Amran M. AL-Erjan

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102271 - 102271

Published: April 1, 2025

Language: Английский

Citations

0
Synthesis, enzyme inhibition and molecular docking studies of novel 1,2,4-oxadiazole thioether derivatives DOI
Nevin Arıkan Ölmez,

Samir Abbas Ali Noma,

Yunus Kaya

et al.

Medicinal Chemistry Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Language: Английский

Citations

1
Preparation and kinetic studies of a new antibacterial sodium alginate gelatin hydrogel composite DOI Creative Commons

Reem A. ElTatawy,

Amel M. Ismail, Mohammed Salah Ayoup

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 25, 2024

This study involved synthesis of a novel antibacterial heterocyclic compound, sodium 2-(2-(3-phenyl-1, 2, 4-oxadiazol-5-yl) phenoxy) acetate abbreviated as Na-POPA. Further development biocompatible, pH-responsive hydrogel drug carrier prepared utilizing the natural polymers gelatin and alginate. The compound loaded on represented new delivery system. Comprehensive characterization Na-POPA was performed using Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (¹H NMR), carbon-13 (¹³C high-resolution mass spectrometry (HRMS). onto alginate/gelatin under feasible experimental conditions. successful incorporation into matrix confirmed via scanning electron microscopy (SEM), powder X-ray diffraction (pXRD) analysis FT-IR spectroscopy. Cytotoxicity assays revealed that all unloaded induced cell toxicity at large concentration much lower than many reported results. reduced inherent cytotoxicity enhanced its biocompatibility. release kinetics from were evaluated spectrophotometrically different pH conditions simulating biological fluids. rate 1.2 greater 6.8, with higher cumulative observed 6.8. obeyed pseudo-second-order kinetic model, indicating controlled mechanism influenced by hydrogel's physicochemical properties. Electrochemical impedance cyclic voltammetry further pH-dependent. high swelling solubility 6.8 enhance release. larger amount released (target intestine) because more solubility, leaching rather shrinking.

Language: Английский

Citations

0