A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease

Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 31, 2025

Alzheimer's disease is a developing public health concern in aging communities that affects sizable section of the global population. The risk increases with age; it one-third males and two-thirds women. This research attempts to assess effect nano-selenium thymoquinone on Nrf2 gene expression levels (AD). There were five identical groups 50 albino male rats: control group was healthy; an AD positive group; received (5 mg/kg); (2 both. duration treatment 4 weeks. brain tissues evaluated using real-time PCR. mean nano-selenium-treated rats, thymoquinone-treated rats given both treatments all increased significantly compared no treatment. study showed elevated AD.

Language: Английский

Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1354 - 1354

Published: March 18, 2025

Hydrogel delivery systems are popular dosage forms that have a number of advantages, such as ease use, painlessness, increased efficiency due to prolongation rheological, swelling and sorption characteristics, regulation drug release, stimulus sensitivity. Particular interest is shown in hydrogels cellulose ether derivatives the possibility obtaining their modified vary solubility, degree prolonged action, release active substance, well widespread availability, affordability, sourcing raw materials from different sources. Hydroxypropyl methylcellulose (HPMC, “hypromellose”) one most ethers production medicines filler, coating carrier. Research on hydrogel carriers based polymer complexes HPMC using acrylic, citric, lactic acids, PVP, chitosan, Na-CMC, gelatin particular interest, they provide necessary rheological characteristics. There growing medical transdermal hydrogels, films, capsules, membranes, nanocrystals, nanofibers with incorporation biologically substances (BASs), especially those plant origin, antibacterial, wound-healing, antimicrobial, mucoadhesive, anti-inflammatory, antioxidant agents. The aim this article review modern research achievements field ethers, particularly HPMC, analyzing properties, methods production, prospects for application medicine pharmacy.

Language: Английский

Insight into bioactive glass and bio-ceramics uses: unveiling recent advances for biomedical application

Discover Materials, Journal Year: 2025, Volume and Issue: 5(1)

Published: April 25, 2025

Language: Английский