Characteristics of Global Methylation Changes in F1 Mice Sperm DNA Induced by Gestational Arsenic Exposure Are Re‐Established in F2 Somatic Cells but Not in F2 Germ Cells DOI
Takehiro Suzuki, Kazuyuki Okamura,

Keiko Nohara

et al.

Genes to Cells, Journal Year: 2025, Volume and Issue: 30(3)

Published: April 29, 2025

ABSTRACT Gestational exposure to chemicals has been reported transmit epigenetic modifications of germ cells not only somatic but also the next generation, resulting in adverse effects. Arsenic is one environmental greatest concern, it precisely clarified whether and how F1 sperm caused by gestational are transmitted generation cells. In present study, we examined effects arsenic during gestation on DNA methylation line F2. The methylome F2 was analyzed reduced representation bisulfite sequencing (RRBS) compared that liver testis. We found testis from group exhibited decrease global levels bias DMC distribution toward hypoDMC observed which have previously reported, did exhibit those characteristics. These studies suggest characteristics induced reestablished

Language: Английский

Effects of Environmental Non-Essential Toxic Heavy Metals on Epigenetics During Development DOI Creative Commons
Hisaka Kurita,

Kazuki Ohuchi,

Masatoshi Inden

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 167 - 167

Published: Feb. 27, 2025

We are exposed to a variety of environmental chemicals in our daily lives. It is possible that the effects this chemical exposure could accumulate organism some form and influence health disease development. The extend throughout human lifetime, not only after birth, but also during embryonic period. Epigenetics an important target for molecular mechanisms effects. mechanism gene transcription regulation does involve changes DNA sequence. Developmental Origins Health Disease (DOHaD) theory has been proposed, which such as period mediated by epigenetic changes, may lead risk development adverse maturity. This review summarizes association between epigenetics well-known non-essential toxic heavy metals (methylmercury, cadmium, arsenic, lead), representative group chemicals. In future, it will be predict unknown combined exposures. addition, further experimental investigations using animals accumulation knowledge needed study transgenerational future.

Language: Английский

Citations

1
Characteristics of Global Methylation Changes in F1 Mice Sperm DNA Induced by Gestational Arsenic Exposure Are Re‐Established in F2 Somatic Cells but Not in F2 Germ Cells DOI
Takehiro Suzuki, Kazuyuki Okamura,

Keiko Nohara

et al.

Genes to Cells, Journal Year: 2025, Volume and Issue: 30(3)

Published: April 29, 2025

ABSTRACT Gestational exposure to chemicals has been reported transmit epigenetic modifications of germ cells not only somatic but also the next generation, resulting in adverse effects. Arsenic is one environmental greatest concern, it precisely clarified whether and how F1 sperm caused by gestational are transmitted generation cells. In present study, we examined effects arsenic during gestation on DNA methylation line F2. The methylome F2 was analyzed reduced representation bisulfite sequencing (RRBS) compared that liver testis. We found testis from group exhibited decrease global levels bias DMC distribution toward hypoDMC observed which have previously reported, did exhibit those characteristics. These studies suggest characteristics induced reestablished

Language: Английский

Citations

0