Decoding Macrophage Dynamics: A Pathway to Understanding and Treating Inflammatory Skin Diseases DOI Open Access

Shengliang Gu,

Lei Xu,

Huang Bin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4287 - 4287

Published: May 1, 2025

Psoriasis and atopic dermatitis (AD) are both chronic inflammatory skin diseases. Their pathogenesis remains incompletely understood. The polarization states of macrophages, as a crucial part the innate immune system, influenced by various factors such cytokines, mediators, epigenetics. Research has demonstrated that macrophages play “double-edged sword” role in pathological process diseases: they drive inflammation progression participate tissue repair. This article summarizes roles development homeostasis psoriasis dermatitis. It explores impact different on In conclusion, understanding classification plasticity is for deeper AD personalized treatments.

Language: Английский

ULK2 Deficiency Stratifies Autophagy-Driven Molecular Subtypes and Exacerbates Trophoblasts Apoptosis in Preeclampsia DOI Creative Commons

Jianfeng Gan,

Wenhan Zhou, Huanqiang Zhao

et al.

Placenta, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Epigenetic Control of Alveolar Macrophages: Impact on Lung Health and Disease DOI Creative Commons
Nirmal Parajuli, Kalpana Subedi, Xzaviar Kaymar Solone

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 640 - 640

Published: April 25, 2025

Alveolar macrophages (AMs) are immune cells located in the alveoli—the tiny air sacs lungs where gas exchange occurs. Their functions regulated by various epigenetic mechanisms, which essential for both healthy lung function and disease development. In lung’s microenvironment, AMs play critical roles surveillance, pathogen clearance, tissue repair. This review examines how regulation influences AM their involvement diseases. Key such as DNA methylation, histone modifications, non-coding RNAs, regulate gene expression response to environmental signals. lungs, these modifications enable quickly respond inhaled threats. However, when processes malfunction, they could contribute diseases pulmonary fibrosis, COPD, hypertension. By exploring changes affect polarization, plasticity, responses, we can gain deeper insights into role open new avenues treating preventing respiratory conditions. Ultimately, understanding mechanisms within enhances our knowledge of immunology offers potential innovative interventions restore health prevent

Language: Английский

Citations

0
Sepsis-induced immunosuppression: mechanisms, biomarkers and immunotherapy DOI Creative Commons

Xun Gao,

Shijie Cai, Xiaoli Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 29, 2025

Sepsis, a life-threatening organ dysfunction resulting from dysregulated host response to infection, initiates complex immune that varies over time, characterized by sustained excessive inflammation and immunosuppression. Sepsis-induced immunosuppression is now recognized as major cause of septic death, identifying effective strategies counteract it poses significant challenge. This results the disruption homeostasis, abnormal death effector cells, hyperproliferation suppressor release anti-inflammatory cytokines, expression checkpoints. Preclinical studies targeting immunosuppression, particularly with checkpoint inhibitors, have shown promise in reversing immunocyte dysfunctions establishing resistance pathogens. Here, our review highlights mechanisms sepsis-induced current diagnostic biomarkers, well immune-enhancing evaluated patients therapeutics under investigation.

Language: Английский

Citations

0
Decoding Macrophage Dynamics: A Pathway to Understanding and Treating Inflammatory Skin Diseases DOI Open Access

Shengliang Gu,

Lei Xu,

Huang Bin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4287 - 4287

Published: May 1, 2025

Psoriasis and atopic dermatitis (AD) are both chronic inflammatory skin diseases. Their pathogenesis remains incompletely understood. The polarization states of macrophages, as a crucial part the innate immune system, influenced by various factors such cytokines, mediators, epigenetics. Research has demonstrated that macrophages play “double-edged sword” role in pathological process diseases: they drive inflammation progression participate tissue repair. This article summarizes roles development homeostasis psoriasis dermatitis. It explores impact different on In conclusion, understanding classification plasticity is for deeper AD personalized treatments.

Language: Английский

Citations

0