Cancer Epidemiology Biomarkers & Prevention,
Journal Year:
2020,
Volume and Issue:
29(10), P. 1856 - 1868
Published: July 29, 2020
The
microbiome
has
been
hypothesized
to
play
a
role
in
cancer
development.
Because
of
the
diversity
published
data,
an
overview
available
epidemiologic
evidence
linking
with
is
now
needed.
We
conducted
systematic
review
using
tailored
search
strategy
Medline
and
EMBASE
databases
identify
summarize
current
literature
on
relationship
between
different
outcomes
until
December
2019.
identified
124
eligible
articles.
large
parameters
used
describe
microbial
composition
made
it
impossible
harmonize
studies
way
that
would
allow
meta-analysis,
therefore
only
qualitative
description
results
could
be
performed.
Fifty
reported
differences
gut
patients
colorectal
various
control
groups.
most
consistent
findings
were
for
Fusobacterium,
Porphyromonas,
Peptostreptococcus
being
significantly
enriched
fecal
mucosal
samples
from
cancer.
For
oral
microbiome,
increased
decreased
abundance
was
Fusobacterium
Streptococcus,
respectively,
compared
controls.
Overall,
although
there
amount
some
these
alterations,
require
validation
high-quality,
preferably
prospective,
studies.
Gut Microbes,
Journal Year:
2021,
Volume and Issue:
13(1), P. 1 - 12
Published: Jan. 1, 2021
Colorectal
cancer
(CRC)
is
the
third
most
commonly
diagnosed
cancer,
leading
cause
of
cancer-related
deaths,
and
has
been
on
rise
among
young
adults
in
United
States.
Research
established
that
colonic
microbiome
different
patients
with
CRC
compared
to
healthy
controls,
but
few
studies
have
investigated
if
how
may
relate
progression
through
serrated
pathway
versus
adenoma-carcinoma
sequence.Our
view
progress
research
requires
consideration
contribute
carcinogenesis
distinct
pathways
lead
CRC,
which
could
enable
creation
novel
tailored
prevention,
screening,
therapeutic
interventions.
We
first
highlight
limitations
existing
offer
corresponding
solutions
for
investigating
microbiome's
role
sequence
pathway.
then
summarize
findings
select
human
included
data
points
related
two
major
carcinogenic
pathways.
These
investigate
1)
utilize
mucosal
samples
2)
compare
polyps
or
tumors
by
histopathologic
type,
molecular/genetic
location
colon.Key
from
these
include:
Fusobacterium
associated
right-sided,
more
advanced,
lesions;
colons
people
bacteria
typically
normal
oral
flora;
3)
biofilms,
biofilms
are
predominantly
located
proximal
colon
(single
study).
Current Opinion in Systems Biology,
Journal Year:
2021,
Volume and Issue:
27, P. 100346 - 100346
Published: May 21, 2021
Microbial
communities
are
near
universally
present
in
nature.
A
wealth
of
meta-omics
data
has
been
gathered
from
numerous
ecosystems,
such
as
the
human
gut,
ocean
or
soil.
Constraint-based
reconstruction
and
analysis
is
a
valuable
tool
for
contextualisation
allows
mechanistic
prediction
metabolic
fluxes.
Advances
genome-scale
multispecies
modelling
tools
have
enabled
construction
interrogation
constraint-based
models
on
microbiome
scale
spanning
hundreds
organisms.
Here,
we
give
comprehensive
overview
areas
application
these
multiscale,
strain-
molecule-resolved
models,
discuss
key
works,
which
computational
yielded
novel
biological
knowledge.
We
show
that
can
complement
experimental
approaches
applications
ecology,
health,
industry
to
environmental
conservation.
Cells,
Journal Year:
2024,
Volume and Issue:
13(17), P. 1437 - 1437
Published: Aug. 27, 2024
The
gut
microbiota
plays
an
essential
role
in
maintaining
immune
homeostasis
and
influencing
the
landscape
within
tumor
microenvironment.
This
review
aims
to
elucidate
interactions
between
dynamics,
with
a
focus
on
colorectal
cancer
(CRC).
spans
foundational
concepts
of
immuno-microbial
interplay,
factors
microbiome
composition,
evidence
linking
immunotherapy
outcomes.
Gut
modulates
anti-cancer
immunity
through
several
mechanisms,
including
enhancement
surveillance
modulation
inflammatory
responses.
Specific
microbial
species
their
metabolic
byproducts
can
significantly
influence
efficacy
immunotherapies.
Furthermore,
diversity
correlates
clinical
outcomes
CRC,
suggesting
potential
as
valuable
biomarker
for
predicting
response
immunotherapy.
Conclusions:
Understanding
relationship
responses
offers
novel
therapeutic
strategies
development.
not
only
influences
natural
history
treatment
CRC
but
also
serves
critical
modulator
activity.
Further
exploration
into
microbiome's
could
enhance
effectiveness
existing
treatments
guide
development
new
modalities.
Cancer Epidemiology Biomarkers & Prevention,
Journal Year:
2020,
Volume and Issue:
29(10), P. 1856 - 1868
Published: July 29, 2020
The
microbiome
has
been
hypothesized
to
play
a
role
in
cancer
development.
Because
of
the
diversity
published
data,
an
overview
available
epidemiologic
evidence
linking
with
is
now
needed.
We
conducted
systematic
review
using
tailored
search
strategy
Medline
and
EMBASE
databases
identify
summarize
current
literature
on
relationship
between
different
outcomes
until
December
2019.
identified
124
eligible
articles.
large
parameters
used
describe
microbial
composition
made
it
impossible
harmonize
studies
way
that
would
allow
meta-analysis,
therefore
only
qualitative
description
results
could
be
performed.
Fifty
reported
differences
gut
patients
colorectal
various
control
groups.
most
consistent
findings
were
for
Fusobacterium,
Porphyromonas,
Peptostreptococcus
being
significantly
enriched
fecal
mucosal
samples
from
cancer.
For
oral
microbiome,
increased
decreased
abundance
was
Fusobacterium
Streptococcus,
respectively,
compared
controls.
Overall,
although
there
amount
some
these
alterations,
require
validation
high-quality,
preferably
prospective,
studies.
