Innate Immunity in Cardiovascular Diseases—Identification of Novel Molecular Players and Targets

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(1), P. 335 - 335

Published: Jan. 1, 2023

During the past few years, unexpected developments have driven studies in field of clinical immunology. One driver immense impact was outbreak a pandemic caused by novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects immunological re-search into cardiovascular diseases. Here, we specifically focus on selected taking advantage advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics chemogenetics. First, discuss emerging relevance diagnostics for diseases, including those associated with COVID-19—with role inflammation cardiomyopathies arrhythmias. Second, consider newly identified interactions at organ system levels which affect pathogenesis. Thus, immune influences arising intestinal are moving towards therapeutic exploitation. Further, powerful new research tools enabled insight brain–immune unprecedented resolution. This latter line investigation emphasizes strength influence emotional stress—acting through defined brain regions—upon viral disorders. Several challenges need be overcome before full these far-reaching findings will hit arena.

Language: Английский

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Saliva microbiome in relation to SARS-CoV-2 infection in a prospective cohort of healthy US adults

EBioMedicine, Journal Year: 2023, Volume and Issue: 94, P. 104731 - 104731

Published: July 22, 2023

The clinical outcomes of SARS-CoV-2 infection vary in severity, potentially influenced by the resident human microbiota. There is limited consensus on conserved microbiome changes response to infection, with many studies focusing severely ill individuals. This study aimed assess variation upper respiratory tract using saliva specimens a cohort individuals primarily mild moderate disease.

Language: Английский

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COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine

Reports — Medical Cases Images and Videos, Journal Year: 2023, Volume and Issue: 6(4), P. 45 - 45

Published: Sept. 22, 2023

During the COVID-19 pandemic, it became apparent that precision medicine relies heavily on biological multi-omics discoveries. High throughput omics technologies, such as host genomics, transcriptomics, proteomics, epigenomics, metabolomics/lipidomics, and microbiomics, have become an integral part of diagnostics. The large number data generated by technologies allows for identification vulnerable demographic populations are susceptible to poor disease outcomes. Additionally, these help pinpoint omics-based biomarkers currently driving advancements in preventive medicine, early diagnosis prognosis, individualized treatments, vaccination. This report summarizes COVID-19-omic studies, highlights results completed ongoing investigations individuals who experienced severe outcomes, examines impact repurposed/novel antiviral drugs, targeted immunotherapeutics, vaccines had individual public health.

Language: Английский

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Analysis of Epidemiological Factors and SNP rs3804100 of TLR2 for COVID-19 in a Cohort of Professionals Who Worked in the First Pandemic Wave in Belém-PA, Brazil

Genes, Journal Year: 2023, Volume and Issue: 14(10), P. 1907 - 1907

Published: Oct. 5, 2023

COVID-19 is an infectious disease caused by coronavirus 2 of the severe acute syndrome (SARS-CoV-2). Single nucleotide polymorphisms (SNPs) in genes, such as TLR2, responsible for effective human immune response, can change course infection. The objective this article was to verify associations between epidemiological factors and TLR2 SNP rs3804100 (Thymine [T] > Cytosine [C]) professionals from Health Institutions (HI) who worked during first pandemic wave COVID-19. A case-control study conducted with Belém-PA HI workers (Northern Brazil), divided into symptomatology groups (Asymptomatic-AS; n = 91; Symptomatic-SI; 123); severity classified Chest Computerized Tomography data (symptomatic pulmonary involvement-SCP; 35; symptomatic without involvement-SSP; 8). Genotyping performed Sanger sequencing, Statistical Analysis through SPSS program. Bioinformatics servers predicted biological functions SNP. There were presence comorbidities poor prognosis (especially overweight obesity) sickness family members kinship (related blood relatives). homozygous recessive (C/C) genotype not found, frequency mutant allele (C) less than 10% cohort. No significant found indicated be benign causes a decrease stability protein. These help scientific community medicine find new forms containment.

Language: Английский

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Oct. 25, 2022

We previously reported inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity in 1-5% unvaccinated patients with life-threatening COVID-19, auto-antibodies against IFN another 15-20% cases.We report here a genome-wide rare variant burden association analysis 3,269 COVID-19 (1,301 1,968 new patients), 1,373 SARS-CoV-2-infected individuals without pneumonia. A quarter the tested had antibodies (234 928) were excluded from analysis.No gene reached significance. Under recessive model, most significant at-risk variants was TLR7 , an OR 27.68 (95%CI:1.5-528.7, P= 1.1×10 -4 ), analyses restricted to biochemically loss-of-function (bLOF) variants. replicated enrichment predicted LOF (pLOF) at 13 influenza susceptibility loci involved TLR3-dependent (OR=3.70 [95%CI:1.3-8.2], 2.1×10 ). Adding recently TYK2 locus strengthened this enrichment, particularly under model (OR=19.65 [95%CI:2.1-2635.4]; 3.4×10 -3 When these 14 considered, all hemizygous ( n =20) or homozygous =5) for pLOF bLOF (OR=39.19 [95%CI:5.2-5037.0], P =4.7×10 -7 who also showed heterozygous (OR=2.36 [95%CI:1.0-5.9], =0.02). Finally, 15 significantly younger (mean age [SD]=43.3 [20.3] years) than other (56.0 [17.3] years; 1.68×10 -5 ).Rare genes can underlie inheritance, 60 years old.

Language: Английский

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